1SVG

Crystal Structure of Protein Kinase A in Complex with Azepane Derivative 4

Summary for 1SVG

• Entry DOI: 10.2210/pdb1svg/pdb
• Related: 1SVE 1SVH 1VEB
• Descriptor: cAMP-dependent protein kinase, alpha-catalytic subunit, CAMP-DEPENDENT PROTEIN KINASE INHIBITOR, ALPHA FORM, N-{(3R,4R)-4-[4-(2-FLUORO-6-HYDROXY-3-METHOXY-BENZOYL)-BENZOYLAMINO]-AZEPAN-3-YL}ISONICOTINAMIDE, ... (4 entities in total)
• Functional Keywords: kinase-inhibitor-complex, serine/threonine-protein kinase, balanol derivative, transferase
• Biological source: Bos taurus (cattle); More
• Cellular location: Cytoplasm: P00517
• Total number of polymer chains: 2
• Total formula weight: 43519.33

Authors

Breitenlechner, C.B.,Wegge, T.,Berillon, L.,Graul, K.,Marzenell, K.,Friebe, W.-G.,Thomas, U.,Schumacher, R.,Huber, R.,Engh, R.A.,Masjost, B. (deposition date: 2004-03-29, release date: 2005-03-29, Last modification date: 2011-07-13)

• Primary citation: Breitenlechner, C.B.,Wegge, T.,Berillon, L.,Graul, K.,Marzenell, K.,Friebe, W.-G.,Thomas, U.,Schumacher, R.,Huber, R.,Engh, R.A.,Masjost, B.; Structure-based optimization of novel azepane derivatives as PKB inhibitors; J.Med.Chem., 47:1375-1390, 2004; PubMed: 14998327; DOI: 10.1021/jm0310479

Experimental method

X-RAY DIFFRACTION (2.02 Å)