1Q8W

The Catalytic Subunit of cAMP-dependent Protein Kinase in Complex with Rho-kinase Inhibitor Fasudil (HA-1077)

Summary for 1Q8W

Entry DOI	10.2210/pdb1q8w/pdb
Related	1Q8T 1Q8U
Descriptor	cAMP-dependent protein kinase, alpha-catalytic subunit, cAMP-dependent protein kinase inhibitor, alpha form, 5-(1,4-DIAZEPAN-1-SULFONYL)ISOQUINOLINE, ... (4 entities in total)
Functional Keywords	kinase-inhibitor-complex, phosphotransferase/inhibitor, camp, phosphorylation, serine/threonine-protein kinase, atp-binding, pka, rho-kinase, transferase-transferase inhibitor complex, transferase/transferase inhibitor
Biological source	Bos taurus (cattle) More
Cellular location	Cytoplasm: P00517
Total number of polymer chains	2
Total formula weight	43304.17
Authors	Breitenlechner, C.,Gassel, M.,Hidaka, H.,Kinzel, V.,Huber, R.,Engh, R.A.,Bossemeyer, D. (deposition date: 2003-08-22, release date: 2003-12-16, Last modification date: 2011-07-13)
Primary citation	Breitenlechner, C.,Gassel, M.,Hidaka, H.,Kinzel, V.,Huber, R.,Engh, R.A.,Bossemeyer, D. Protein kinase A in complex with Rho-kinase inhibitors Y-27632, Fasudil, and H-1152P: structural basis of selectivity. Structure, 11:1595-1607, 2003 Cited by PubMed: 14656443 DOI: 10.1016/j.str.2003.11.002 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.2 Å)

Structure validation