1YDT

STRUCTURE OF CAMP-DEPENDENT PROTEIN KINASE, ALPHA-CATALYTIC SUBUNIT IN COMPLEX WITH H89 PROTEIN KINASE INHIBITOR N-[2-(4-BROMOCINNAMYLAMINO)ETHYL]-5-ISOQUINOLINE

Summary for 1YDT

Entry DOI	10.2210/pdb1ydt/pdb
Descriptor	C-AMP-DEPENDENT PROTEIN KINASE, PROTEIN KINASE INHIBITOR PEPTIDE, N-[2-(4-BROMOCINNAMYLAMINO)ETHYL]-5-ISOQUINOLINE SULFONAMIDE, ... (4 entities in total)
Functional Keywords	complex (phosphotransferase-inhibitor), transferase, camp, phosphorylation, isoquinoline sulfonamide, serine/threonine-protein kinase, atp-binding, complex (phosphotransferase-inhibitor) complex, complex (phosphotransferase/inhibitor)
Biological source	Bos taurus (cattle)
Cellular location	Cytoplasm: P00517
Total number of polymer chains	2
Total formula weight	43354.13
Authors	Engh, R.A.,Girod, A.,Kinzel, V.,Huber, R.,Bossemeyer, D. (deposition date: 1996-07-24, release date: 1997-04-01, Last modification date: 2011-07-13)
Primary citation	Engh, R.A.,Girod, A.,Kinzel, V.,Huber, R.,Bossemeyer, D. Crystal structures of catalytic subunit of cAMP-dependent protein kinase in complex with isoquinolinesulfonyl protein kinase inhibitors H7, H8, and H89. Structural implications for selectivity. J.Biol.Chem., 271:26157-26164, 1996 Cited by PubMed: 8824261 DOI: 10.1074/jbc.271.42.26157 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.3 Å)

Structure validation