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1ITP
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1itp
SOLUTION STRUCTURE OF POIA1
Descriptor:proteinase A inhibitor 1
Authors:Sasakawa, H., Yoshinaga, S., Kojima, S., Tamura, A.
Deposit date:2002-01-23
Release date:2002-02-13
Modification date:2009-02-24
Method:SOLUTION NMR
Cite:Structure of POIA1, a homologous protein to the propeptide of subtilisin: implication for protein foldability and the function as an intramolecular chaperone.
J.Mol.Biol., 317, 2002
1SPB
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1spb
SUBTILISIN BPN' PROSEGMENT (77 RESIDUES) COMPLEXED WITH A MUTANT SUBTILISIN BPN' (266 RESIDUES). CRYSTAL PH 4.6. CRYSTALLIZATION TEMPERATURE 20 C DIFFRACTION TEMPERATURE-160 C
Descriptor:SUBTILISIN BPN' PROSEGMENT
Authors:Gallagher, D.T., Gilliland, G.L., Wang, L., Bryan, P.N.
Deposit date:1995-06-21
Release date:1995-10-15
Modification date:2009-02-24
Method:X-RAY DIFFRACTION (2 Å)
Cite:The prosegment-subtilisin BPN' complex: crystal structure of a specific 'foldase'.
Structure, 3, 1995
2PMW
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2pmw
THE CRYSTAL STRUCTURE OF PROPROTEIN CONVERTASE SUBTILISIN KEXIN TYPE 9 (PCSK9)
Descriptor:Proprotein convertase subtilisin/kexin type 9 (E.C.3.4.21.-)
Authors:Piper, D.E., Romanow, W.G., Thibault, S.T., Walker, N.P.C.
Deposit date:2007-04-23
Release date:2007-05-08
Modification date:2009-02-24
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:The Crystal Structure of PCSK9: A Regulator of Plasma LDL-Cholesterol.
Structure, 15, 2007
2QTW
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2qtw
THE CRYSTAL STRUCTURE OF PCSK9 AT 1.9 ANGSTROMS RESOLUTION REVEALS STRUCTURAL HOMOLOGY TO RESISTIN WITHIN THE C-TERMINAL DOMAIN
Descriptor:Proprotein convertase subtilisin/kexin type 9 (E.C.3.4.21.-)
Authors:Hampton, E.N., Knuth, M.W., Li, J., Harris, J.L., Lesley, S.A., Spraggon, G.
Deposit date:2007-08-02
Release date:2007-09-18
Modification date:2013-09-18
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:The self-inhibited structure of full-length PCSK9 at 1.9 A reveals structural homology with resistin within the C-terminal domain.
Proc.Natl.Acad.Sci.Usa, 104, 2007
3BGO
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3bgo
AZIDE COMPLEX OF ENGINEERED SUBTILISIN SUBT_BACAM
Descriptor:Azide complex of Engineered Subtilisin SUBT_BACAM
Authors:Gallagher, D.T., Bryan, P.N.
Deposit date:2007-11-27
Release date:2008-06-03
Modification date:2009-02-24
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Azide complex of Engineered Subtilisin SUBT_BACAM
To be Published
3BPS
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3bps
PCSK9:EGF-A COMPLEX
Descriptor:Proprotein convertase subtilisin/kexin type 9 (E.C.3.4.21.-), Low-density lipoprotein receptor
Authors:Kwon, H.J.
Deposit date:2007-12-19
Release date:2008-02-12
Modification date:2011-07-13
Method:X-RAY DIFFRACTION (2.41 Å)
Cite:Molecular basis for LDL receptor recognition by PCSK9.
Proc.Natl.Acad.Sci.Usa, 105, 2008
3CNQ
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3cnq
PROSUBTILISIN SUBSTRATE COMPLEX OF SUBTILISIN SUBT_BACAM
Descriptor:Substrate Complex of Subtilisin SUBT_BACAM
Authors:Gallagher, D.T., Bryan, P.N.
Deposit date:2008-03-26
Release date:2008-05-06
Modification date:2010-04-21
Method:X-RAY DIFFRACTION (1.71 Å)
Cite:Engineering substrate preference in subtilisin: structural and kinetic analysis of a specificity mutant.
Biochemistry, 47, 2008
3CO0
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3co0
SUBSTRATE COMPLEX OF FLUORIDE-SENSITIVE ENGINEERED SUBTILISIN SUBT_BACAM
Descriptor:Substrate Complex of Fluoride-sensitive Engineered Subtilisin SUBT_BACAM
Authors:Gallagher, D.T., Bryan, P.N.
Deposit date:2008-03-26
Release date:2008-10-14
Modification date:2009-02-24
Method:X-RAY DIFFRACTION (1.93 Å)
Cite:Substrate Complex of Fluoride-sensitive Engineered Subtilisin SUBT_BACAM
To be Published
3GCW
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3gcw
PCSK9:EGFA(H306Y)
Descriptor:Proprotein convertase subtilisin/kexin type 9 (E.C.3.4.21.-), Low-density lipoprotein receptor
Authors:Kwon, H.J.
Deposit date:2009-02-22
Release date:2009-03-03
Modification date:2011-07-13
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Antagonism of Secreted PCSK9 Increases Low Density Lipoprotein Receptor Expression in HepG2 Cells.
J.Biol.Chem., 284, 2009
3GCX
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3gcx
PCSK9:EGFA (PH 7.4)
Descriptor:Proprotein convertase subtilisin/kexin type 9 (E.C.3.4.21.-), Low-density lipoprotein receptor
Authors:McNutt, M.C., Kwon, H.J., Chen, C., Chen, J.R., Horton, J.D., Lagace, T.A.
Deposit date:2009-02-22
Release date:2009-03-03
Modification date:2011-07-13
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Antagonism of Secreted PCSK9 Increases Low Density Lipoprotein Receptor Expression in HepG2 Cells.
J.Biol.Chem., 284, 2009
3H42
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3h42
CRYSTAL STRUCTURE OF PCSK9 IN COMPLEX WITH FAB FROM LDLR COMPETITIVE ANTIBODY
Descriptor:Proprotein convertase subtilisin/kexin type 9 (E.C.3.4.21.-), Fab from LDLR competitive antibody: Light chain, IGHM protein
Authors:Piper, D.E., Walker, N.P.C., Romanow, W.G., Thibault, S.T., Tsai, M.M., Yang, E.
Deposit date:2009-04-17
Release date:2009-05-05
Modification date:2010-07-21
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:From the Cover: A proprotein convertase subtilisin/kexin type 9 neutralizing antibody reduces serum cholesterol in mice and nonhuman primates.
Proc.Natl.Acad.Sci.USA, 106, 2009
3M0C
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3m0c
THE X-RAY CRYSTAL STRUCTURE OF PCSK9 IN COMPLEX WITH THE LDL RECEPTOR
Descriptor:Proprotein convertase subtilisin/kexin type 9 (E.C.3.4.21.-), Low-density lipoprotein receptor
Authors:Spraggon, G., Hampton, E.N.
Deposit date:2010-03-02
Release date:2011-03-16
Method:X-RAY DIFFRACTION (7.01 Å)
Cite:The X-ray Crystal Structure of PCSK9 in Complex with the LDL receptor
To be Published
3P5B
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3p5b
THE STRUCTURE OF THE LDLR/PCSK9 COMPLEX REVEALS THE RECEPTOR IN AN EXTENDED CONFORMATION
Descriptor:Proprotein convertase subtilisin/kexin type 9 (E.C.3.4.21.-), Low density lipoprotein receptor variant
Authors:Lo Surdo, P., Bottomley, M.J., Calzetta, A., Settembre, E.C., Cirillo, A., Pandit, S., Ni, Y., Hubbard, B., Sitlani, A., Carfi, A.
Deposit date:2010-10-08
Release date:2011-10-26
Method:X-RAY DIFFRACTION (3.3 Å)
Cite:The structure of the LDLR/PCSK9 complex reveals the receptor in an extended conformation
To be Published
3P5C
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3p5c
THE STRUCTURE OF THE LDLR/PCSK9 COMPLEX REVEALS THE RECEPTOR IN AN EXTENDED CONFORMATION
Descriptor:Proprotein convertase subtilisin/kexin type 9 (E.C.3.4.21.-), Low density lipoprotein receptor variant
Authors:Lo Surdo, P., Bottomley, M.J., Calzetta, A., Settembre, E.C., Cirillo, A., Pandit, S., Ni, Y., Hubbard, B., Sitlani, A., Carfi, A.
Deposit date:2010-10-08
Release date:2011-10-26
Method:X-RAY DIFFRACTION (4.2 Å)
Cite:The structure of the LDLR/PCSK9 complex reveals the receptor in an extended conformation
To be Published
3WHI
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3whi
CRYSTAL STRUCTURE OF UNAUTOPROCESSED FORM OF IS1-INSERTED PRO-SUBTILISIN E
Descriptor:Subtilisin E (E.C.3.4.21.62)
Authors:Uehara, R., Angkawidjaja, C., Koga, Y., Kanaya, S.
Deposit date:2013-08-26
Release date:2013-12-25
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Formation of the High-Affinity Calcium Binding Site in Pro-subtilisin E with the Insertion Sequence IS1 of Pro-Tk-subtilisin
Biochemistry, 52, 2013
4K8R
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4k8r
AN ANTIBODY AGAINST THE C-TERMINAL DOMAIN OF PCSK9 LOWERS LDL CHOLESTEROL LEVELS IN VIVO
Descriptor:Proprotein convertase subtilisin/kexin type 9 (E.C.3.4.21.-), PCSK9
Authors:Schiele, F., Nar, H.
Deposit date:2013-04-18
Release date:2013-05-08
Modification date:2014-02-19
Method:X-RAY DIFFRACTION (3.22 Å)
Cite:An Antibody against the C-Terminal Domain of PCSK9 Lowers LDL Cholesterol Levels In Vivo.
J.Mol.Biol., 426, 2014
4NMX
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4nmx
PCSK9(DELTACRD) IN COMPLEX WITH PHAGE-DERIVED INHIBITORY PEPTIDE 2-8
Descriptor:Proprotein convertase subtilisin/kexin type 9 (E.C.3.4.21.-), peptide 2-8
Authors:Eigenbrot, C., Shia, S.
Deposit date:2013-11-15
Release date:2013-12-04
Modification date:2014-01-29
Method:X-RAY DIFFRACTION (1.85 Å)
Cite:Identification of a Small Peptide That Inhibits PCSK9 Protein Binding to the Low Density Lipoprotein Receptor.
J.Biol.Chem., 289, 2014
1SCJ
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1scj
CRYSTAL STRUCTURE OF SUBTILISIN-PROPEPTIDE COMPLEX
Descriptor:SUBTILISIN E
Authors:Berman, H.M., Jain, S.C.
Deposit date:1998-04-29
Release date:1998-12-09
Modification date:2009-02-24
Method:X-RAY DIFFRACTION (2 Å)
Cite:The crystal structure of an autoprocessed Ser221Cys-subtilisin E-propeptide complex at 2.0 A resolution.
J.Mol.Biol., 284, 1998
1V5I
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1v5i
CRYSTAL STRUCTURE OF SERINE PROTEASE INHIBITOR POIA1 IN COMPLEX WITH SUBTILISIN BPN'
Descriptor:Subtilisin BPN'(E.C.3.4.21.62)/IA-1=serine proteinase inhibitor
Authors:Lee, W.C., Kikkawa, M., Kojima, S., Miura, K., Tanokura, M.
Deposit date:2003-11-24
Release date:2005-03-08
Modification date:2011-07-13
Method:X-RAY DIFFRACTION (1.5 Å)
Cite:Crystal structure of serine protease inhibitor POIA1 in complex with subtilisin BPN'
To be Published
2W2M
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2w2m
WT PCSK9-DELTAC BOUND TO WT EGF-A OF LDLR
Descriptor:PROPROTEIN CONVERTASE SUBTILISIN/KEXIN TYPE 9 (E.C.3.4.21.-), LOW-DENSITY LIPOPROTEIN RECEPTOR
Authors:Bottomley, M.J., Cirillo, A., Orsatti, L., Ruggeri, L., Fisher, T.S., Santoro, J.C., Cummings, R.T., Cubbon, R.M., Lo Surdo, P., Calzetta, A., Noto, A., Baysarowich, J., Mattu, M., Talamo, F., De Francesco, R., Sparrow, C.P., Sitlani, A., Carfi, A.
Deposit date:2008-11-03
Release date:2008-11-18
Modification date:2011-07-13
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Structural and Biochemical Characterization of the Wild Type Pcsk9/Egf-Ab Complex and Natural Fh Mutants.
J.Biol.Chem., 284, 2009
2W2N
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2w2n
WT PCSK9-DELTAC BOUND TO EGF-A H306Y MUTANT OF LDLR
Descriptor:PROPROTEIN CONVERTASE SUBTILISIN/KEXIN TYPE 9 (E.C.3.4.21.-), LOW-DENSITY LIPOPROTEIN RECEPTOR
Authors:Bottomley, M.J., Cirillo, A., Orsatti, L., Ruggeri, L., Fisher, T.S., Santoro, J.C., Cummings, R.T., Cubbon, R.M., Lo Surdo, P., Calzetta, A., Noto, A., Baysarowich, J., Mattu, M., Talamo, F., De Francesco, R., Sparrow, C.P., Sitlani, A., Carfi, A.
Deposit date:2008-11-03
Release date:2008-11-18
Modification date:2011-07-13
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Structural and Biochemical Characterization of the Wild Type Pcsk9/Egf-Ab Complex and Natural Fh Mutants.
J.Biol.Chem., 284, 2009
2W2O
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2w2o
PCSK9-DELTAC D374Y MUTANT BOUND TO WT EGF-A OF LDLR
Descriptor:PROPROTEIN CONVERTASE SUBTILISIN/KEXIN TYPE 9 (E.C.3.4.21.-), LOW-DENSITY LIPOPROTEIN RECEPTOR
Authors:Bottomley, M.J., Cirillo, A., Orsatti, L., Ruggeri, L., Fisher, T.S., Santoro, J.C., Cummings, R.T., Cubbon, R.M., Lo Surdo, P., Calzetta, A., Noto, A., Baysarowich, J., Mattu, M., Talamo, F., De Francesco, R., Sparrow, C.P., Sitlani, A., Carfi, A.
Deposit date:2008-11-03
Release date:2008-11-18
Modification date:2011-07-13
Method:X-RAY DIFFRACTION (2.62 Å)
Cite:Structural and Biochemical Characterization of the Wild Type Pcsk9/Egf-Ab Complex and Natural Fh Mutants.
J.Biol.Chem., 284, 2009
2W2P
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2w2p
PCSK9-DELTAC D374A MUTANT BOUND TO WT EGF-A OF LDLR
Descriptor:PROPROTEIN CONVERTASE SUBTILISIN/KEXIN TYPE 9 (E.C.3.4.21.-), LOW-DENSITY LIPOPROTEIN RECEPTOR
Authors:Bottomley, M.J., Cirillo, A., Orsatti, L., Ruggeri, L., Fisher, T.S., Santoro, J.C., Cummings, R.T., Cubbon, R.M., Lo Surdo, P., Calzetta, A., Noto, A., Baysarowich, J., Mattu, M., Talamo, F., De Francesco, R., Sparrow, C.P., Sitlani, A., Carfi, A.
Deposit date:2008-11-03
Release date:2008-11-18
Modification date:2011-07-13
Method:X-RAY DIFFRACTION (2.62 Å)
Cite:Structural and Biochemical Characterization of the Wild Type Pcsk9/Egf-Ab Complex and Natural Fh Mutants.
J.Biol.Chem., 284, 2009
2W2Q
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2w2q
PCSK9-DELTAC D374H MUTANT BOUND TO WT EGF-A OF LDLR
Descriptor:PROPROTEIN CONVERTASE SUBTILISIN/KEXIN TYPE 9 (E.C.3.4.21.-), LOW-DENSITY LIPOPROTEIN RECEPTOR
Authors:Bottomley, M.J., Cirillo, A., Orsatti, L., Ruggeri, L., Fisher, T.S., Santoro, J.C., Cummings, R.T., Cubbon, R.M., Lo Surdo, P., Calzetta, A., Noto, A., Baysarowich, J., Mattu, M., Talamo, F., De Francesco, R., Sparrow, C.P., Sitlani, A., Carfi, A.
Deposit date:2008-11-03
Release date:2008-11-18
Modification date:2011-07-13
Method:X-RAY DIFFRACTION (2.33 Å)
Cite:Structural and Biochemical Characterization of the Wild Type Pcsk9/Egf-Ab Complex and Natural Fh Mutants.
J.Biol.Chem., 284, 2009
2XTJ
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2xtj
THE CRYSTAL STRUCTURE OF PCSK9 IN COMPLEX WITH 1D05 FAB
Descriptor:PROPROTEIN CONVERTASE SUBTILISIN/KEXIN TYPE 9 (E.C.3.4.21.-), FAB FROM A HUMAN MONOCLONAL ANTIBODY, 1D05, PROPROTEIN CONVERTASE SUBTILISIN-KEXIN TYPE 9 (E.C.3.4.21.-)
Authors:Di Marco, S., Volpari, C., Carfi, A.
Deposit date:2010-10-10
Release date:2010-11-03
Modification date:2010-12-22
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:A Pcsk9-Binding Antibody that Structurally Mimics the Egf(A) Domain of Ldl-Receptor Reduces Ldl Cholesterol in Vivo.
J.Lipid Res., 52, 2011
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