3GCX

PCSK9:EGFA (pH 7.4)

Summary for 3GCX

Entry DOI	10.2210/pdb3gcx/pdb
Related	3GCW
Descriptor	Proprotein convertase subtilisin/kexin type 9, Low-density lipoprotein receptor, CALCIUM ION, ... (4 entities in total)
Functional Keywords	pcsk9, ldl receptor, autocatalytic cleavage, cholesterol metabolism, disease mutation, glycoprotein, hydrolase, lipid metabolism, phosphoprotein, protease, secreted, serine protease, steroid metabolism, zymogen, coated pit, egf-like domain, endocytosis, host-virus interaction, ldl, lipid transport, membrane, receptor, transmembrane, transport, protein binding
Biological source	Homo sapiens (human) More
Cellular location	Secreted: Q8NBP7 Q8NBP7 Cell membrane; Single-pass type I membrane protein: P01130
Total number of polymer chains	3
Total formula weight	77857.85
Authors	McNutt, M.C.,Kwon, H.J.,Chen, C.,Chen, J.R.,Horton, J.D.,Lagace, T.A. (deposition date: 2009-02-22, release date: 2009-03-03, Last modification date: 2023-09-06)
Primary citation	McNutt, M.C.,Kwon, H.J.,Chen, C.,Chen, J.R.,Horton, J.D.,Lagace, T.A. Antagonism of Secreted PCSK9 Increases Low Density Lipoprotein Receptor Expression in HepG2 Cells. J.Biol.Chem., 284:10561-10570, 2009 Cited by PubMed: 19224862 DOI: 10.1074/jbc.M808802200 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.7 Å)

Structure validation