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3GCW

PCSK9:EGFA(H306Y)

Summary for 3GCW
Entry DOI10.2210/pdb3gcw/pdb
Related3GCX
DescriptorProprotein convertase subtilisin/kexin type 9, Low-density lipoprotein receptor, CALCIUM ION, ... (4 entities in total)
Functional Keywordspcsk9, ldl receptor, autocatalytic cleavage, cholesterol metabolism, disease mutation, glycoprotein, hydrolase, lipid metabolism, phosphoprotein, protease, secreted, serine protease, steroid metabolism, zymogen, coated pit, egf-like domain, endocytosis, host-virus interaction, ldl, lipid transport, membrane, receptor, transmembrane, transport, protein binding
Biological sourceHomo sapiens (human)
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Cellular locationSecreted: Q8NBP7 Q8NBP7
Cell membrane; Single-pass type I membrane protein: P01130
Total number of polymer chains3
Total formula weight77882.87
Authors
Kwon, H.J. (deposition date: 2009-02-22, release date: 2009-03-03, Last modification date: 2023-09-06)
Primary citationMcNutt, M.C.,Kwon, H.J.,Chen, C.,Chen, J.R.,Horton, J.D.,Lagace, T.A.
Antagonism of Secreted PCSK9 Increases Low Density Lipoprotein Receptor Expression in HepG2 Cells.
J.Biol.Chem., 284:10561-10570, 2009
Cited by
PubMed: 19224862
DOI: 10.1074/jbc.M808802200
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (2.7 Å)
Structure validation

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