6XIC

PCSK9(deltaCRD) in complex with cyclic peptide 40

Summary for 6XIC

Entry DOI	10.2210/pdb6xic/pdb
Descriptor	Proprotein convertase subtilisin/kexin type 9, Peptide 40, GLYCEROL, ... (5 entities in total)
Functional Keywords	protein-peptide complex, cyclic peptide, non-natural amino acids, hydrolase, hydrolase-inhibitor complex, hydrolase/inhibitor
Biological source	Homo sapiens (human) More
Total number of polymer chains	3
Total formula weight	48013.97
Authors	Orth, P. (deposition date: 2020-06-19, release date: 2020-11-18, Last modification date: 2024-04-24)
Primary citation	Alleyne, C.,Amin, R.P.,Bhatt, B.,Bianchi, E.,Blain, J.C.,Boyer, N.,Branca, D.,Embrey, M.W.,Ha, S.N.,Jette, K.,Johns, D.G.,Kerekes, A.D.,Koeplinger, K.A.,LaPlaca, D.,Li, N.,Murphy, B.,Orth, P.,Ricardo, A.,Salowe, S.,Seyb, K.,Shahripour, A.,Stringer, J.R.,Sun, Y.,Tracy, R.,Wu, C.,Xiong, Y.,Youm, H.,Zokian, H.J.,Tucker, T.J. Series of Novel and Highly Potent Cyclic Peptide PCSK9 Inhibitors Derived from an mRNA Display Screen and Optimized via Structure-Based Design. J.Med.Chem., 63:13796-13824, 2020 Cited by PubMed: 33170686 DOI: 10.1021/acs.jmedchem.0c01084 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.377 Å)

Structure validation