7S5H

PCSK9(deltaCRD) in complex with cyclic peptide 35

Summary for 7S5H

Entry DOI	10.2210/pdb7s5h/pdb
Descriptor	Pro-peptide from Proprotein convertase subtilisin/kexin type 9, Proprotein convertase subtilisin/kexin type 9, Z50-DNP-DAL-PHE-FTR-PRO-THR-0A1-3WX, ... (5 entities in total)
Functional Keywords	cholesterol, ldl receptor, egfa domain, protein binding, hydrolase
Biological source	Homo sapiens (human) More
Total number of polymer chains	3
Total formula weight	48079.09
Authors	Orth, P. (deposition date: 2021-09-10, release date: 2021-11-03, Last modification date: 2024-04-24)
Primary citation	Tucker, T.J.,Embrey, M.W.,Alleyne, C.,Amin, R.P.,Bass, A.,Bhatt, B.,Bianchi, E.,Branca, D.,Bueters, T.,Buist, N.,Ha, S.N.,Hafey, M.,He, H.,Higgins, J.,Johns, D.G.,Kerekes, A.D.,Koeplinger, K.A.,Kuethe, J.T.,Li, N.,Murphy, B.,Orth, P.,Salowe, S.,Shahripour, A.,Tracy, R.,Wang, W.,Wu, C.,Xiong, Y.,Zokian, H.J.,Wood, H.B.,Walji, A. A Series of Novel, Highly Potent, and Orally Bioavailable Next-Generation Tricyclic Peptide PCSK9 Inhibitors. J.Med.Chem., 64:16770-16800, 2021 Cited by PubMed: 34704436 DOI: 10.1021/acs.jmedchem.1c01599 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.272 Å)

Structure validation