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3SQO

PCSK9 J16 Fab complex

Summary for 3SQO
Entry DOI10.2210/pdb3sqo/pdb
DescriptorProprotein convertase subtilisin/kexin type 9, J16 Heavy chain, J16 Light chain, ... (5 entities in total)
Functional Keywordscholesterol regulation, ldlr, hydrolase-immune system complex, hydrolase/immune system
Biological sourceHomo sapiens (human)
More
Cellular locationSecreted: Q8NBP7 Q8NBP7
Total number of polymer chains4
Total formula weight118530.84
Authors
Strop, P. (deposition date: 2011-07-05, release date: 2012-05-16)
Primary citationLiang, H.,Chaparro-Riggers, J.,Strop, P.,Geng, T.,Sutton, J.E.,Tsai, D.,Bai, L.,Abdiche, Y.,Dilley, J.,Yu, J.,Wu, S.,Chin, S.M.,Lee, N.A.,Rossi, A.,Lin, J.C.,Rajpal, A.,Pons, J.,Shelton, D.L.
Proprotein convertase substilisin/kexin type 9 antagonism reduces low-density lipoprotein cholesterol in statin-treated hypercholesterolemic nonhuman primates.
J.Pharmacol.Exp.Ther., 340:228-236, 2012
Cited by
PubMed: 22019884
DOI: 10.1124/jpet.111.187419
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (2.7 Å)
Structure validation

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