3P5B
The structure of the LDLR/PCSK9 complex reveals the receptor in an extended conformation
Summary for 3P5B
Entry DOI | 10.2210/pdb3p5b/pdb |
Related | 3P5C |
Descriptor | Proprotein convertase subtilisin/kexin type 9, Low density lipoprotein receptor variant, CALCIUM ION, ... (4 entities in total) |
Functional Keywords | b-propellor, receptor, convertase, hydrolase-lipid binding protein complex, hydrolase/lipid binding protein |
Biological source | Homo sapiens (human) More |
Cellular location | Cytoplasm: Q8NBP7 Q8NBP7 |
Total number of polymer chains | 3 |
Total formula weight | 112744.54 |
Authors | Lo Surdo, P.,Bottomley, M.J.,Calzetta, A.,Settembre, E.C.,Cirillo, A.,Pandit, S.,Ni, Y.,Hubbard, B.,Sitlani, A.,Carfi, A. (deposition date: 2010-10-08, release date: 2011-10-26, Last modification date: 2017-11-08) |
Primary citation | Lo Surdo, P.,Bottomley, M.J.,Calzetta, A.,Settembre, E.C.,Cirillo, A.,Pandit, S.,Ni, Y.G.,Hubbard, B.,Sitlani, A.,Carfi, A. Mechanistic implications for LDL receptor degradation from the PCSK9/LDLR structure at neutral pH. Embo Rep., 12:1300-1305, 2011 Cited by PubMed: 22081141DOI: 10.1038/embor.2011.205 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (3.3 Å) |
Structure validation
Download full validation report