3P5C

The structure of the LDLR/PCSK9 complex reveals the receptor in an extended conformation

Summary for 3P5C

• Entry DOI: 10.2210/pdb3p5c/pdb
• Related: 3P5B
• Descriptor: Proprotein convertase subtilisin/kexin type 9, Low density lipoprotein receptor variant, CALCIUM ION, ... (4 entities in total)
• Functional Keywords: b-propellor, receptor, convertase, hydrolase-lipid binding protein complex, hydrolase/lipid binding protein
• Biological source: Homo sapiens (human); More
• Cellular location: Cytoplasm: Q8NBP7 Q8NBP7
• Total number of polymer chains: 3
• Total formula weight: 117293.73

Authors

Lo Surdo, P.,Bottomley, M.J.,Calzetta, A.,Settembre, E.C.,Cirillo, A.,Pandit, S.,Ni, Y.,Hubbard, B.,Sitlani, A.,Carfi, A. (deposition date: 2010-10-08, release date: 2011-10-26, Last modification date: 2024-01-17)

• Primary citation: Lo Surdo, P.,Bottomley, M.J.,Calzetta, A.,Settembre, E.C.,Cirillo, A.,Pandit, S.,Ni, Y.G.,Hubbard, B.,Sitlani, A.,Carfi, A.; Mechanistic implications for LDL receptor degradation from the PCSK9/LDLR structure at neutral pH.; Embo Rep., 12:1300-1305, 2011; PubMed: 22081141; DOI: 10.1038/embor.2011.205

Experimental method

X-RAY DIFFRACTION (4.2 Å)