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1PB5	NMR Structure of a Prototype LNR Module from Human Notch1 Descriptor: CALCIUM ION, Neurogenic locus notch homolog protein 1 Authors: Vardar, D, North, C.L, Sanchez-Irizarry, C, Aster, J.C, Blacklow, S.C. Deposit date: 2003-05-14 Release date: 2003-06-17 Last modified: 2022-02-23 Method: SOLUTION NMR Cite: Nuclear Magnetic Resonance Structure of a Prototype Lin12-Notch Repeat Module from Human Notch1 Biochemistry, 42, 2003
3I08	Crystal structure of the S1-cleaved Notch1 Negative Regulatory Region (NRR) Descriptor: CALCIUM ION, CHLORIDE ION, Neurogenic locus notch homolog protein 1 Authors: Gordon, W.R, Blacklow, S.C. Deposit date: 2009-06-24 Release date: 2009-09-01 Last modified: 2023-09-06 Method: X-RAY DIFFRACTION (3.2 Å) Cite: Effects of S1 cleavage on the structure, surface export, and signaling activity of human Notch1 and Notch2. Plos One, 4, 2009
3ETO	2 Angstrom Xray structure of the NOTCH1 Negative Regulatory Region (NRR) Descriptor: CALCIUM ION, CHLORIDE ION, GLYCEROL, ... Authors: Gordon, W.R, Blacklow, S.C. Deposit date: 2008-10-08 Release date: 2008-12-23 Last modified: 2023-09-06 Method: X-RAY DIFFRACTION (2 Å) Cite: Structure of the Notch1-negative regulatory region: implications for normal activation and pathogenic signaling in T-ALL. Blood, 113, 2009
4XL1	Complex of Notch1 (EGF11-13) bound to Delta-like 4 (N-EGF1) Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, ... Authors: Luca, V.C, Jude, K.M, Garcia, K.C. Deposit date: 2015-01-13 Release date: 2015-03-04 Last modified: 2020-07-29 Method: X-RAY DIFFRACTION (2.3 Å) Cite: Structural biology. Structural basis for Notch1 engagement of Delta-like 4. Science, 347, 2015
4XLW	Complex of Notch1 (EGF11-13) bound to Delta-like 4 (N-EGF2) Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, Delta-like protein, ... Authors: Luca, V.C, Jude, K.M, Garcia, K.C. Deposit date: 2015-01-13 Release date: 2015-03-04 Last modified: 2020-07-29 Method: X-RAY DIFFRACTION (3.39 Å) Cite: Structural biology. Structural basis for Notch1 engagement of Delta-like 4. Science, 347, 2015
2HE0	Crystal structure of a human Notch1 ankyrin domain mutant Descriptor: 1,2-ETHANEDIOL, Notch1 preproprotein variant Authors: Gupta, D, Ehebauer, M.T, Chirgadze, D.Y, Martinez Arias, A, Blundell, T.L. Deposit date: 2006-06-21 Release date: 2006-07-04 Last modified: 2023-08-30 Method: X-RAY DIFFRACTION (1.9 Å) Cite: Crystal structure of a human Notch1 ankyrin domain mutant TO BE PUBLISHED
5AIZ	The PIAS-like coactivator Zmiz1 is a direct and selective cofactor of Notch1 in T-cell development and leukemia Descriptor: 1,2-ETHANEDIOL, ACETATE ION, UNKNOWN ATOM OR ION, ... Authors: Cho, H.J, Murai, M, Chiang, M, Cierpicki, T. Deposit date: 2015-02-18 Release date: 2015-10-28 Last modified: 2015-12-02 Method: X-RAY DIFFRACTION (1.7 Å) Cite: The Pias-Like Coactivator Zmiz1 is a Direct and Selective Cofactor of Notch1 in T-Cell Development and Leukemia Immunity, 43, 2015
4D0E	Human Notch1 EGF domains 11-13 mutant GlcNAc-fucose disaccharide modified at T466 Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-3)-alpha-L-fucopyranose, CALCIUM ION, NEUROGENIC LOCUS NOTCH HOMOLOG PROTEIN 1 Authors: Taylor, P, Takeuchi, H, Sheppard, D, Chillakuri, C, Lea, S.M, Haltiwanger, R.S, Handford, P.A. Deposit date: 2014-04-25 Release date: 2014-05-21 Last modified: 2023-12-20 Method: X-RAY DIFFRACTION (1.61 Å) Cite: Fringe-Mediated Extension of O-Linked Fucose in the Ligand-Binding Region of Notch1 Increases Binding to Mammalian Notch Ligands. Proc.Natl.Acad.Sci.USA, 111, 2014
4CUD	Human Notch1 EGF domains 11-13 mutant fucosylated at T466 Descriptor: CALCIUM ION, NEUROGENIC LOCUS NOTCH HOMOLOG PROTEIN 1, alpha-L-fucopyranose Authors: Taylor, P, Takeuchi, H, Sheppard, D, Chillakuri, C, Lea, S.M, Haltiwanger, R.S, Handford, P.A. Deposit date: 2014-03-18 Release date: 2014-05-21 Last modified: 2023-12-20 Method: X-RAY DIFFRACTION (1.85 Å) Cite: Fringe-Mediated Extension of O-Linked Fucose in the Ligand-Binding Region of Notch1 Increases Binding to Mammalian Notch Ligands. Proc.Natl.Acad.Sci.USA, 111, 2014
4CUE	Human Notch1 EGF domains 11-13 mutant T466V Descriptor: CALCIUM ION, NEUROGENIC LOCUS NOTCH HOMOLOG PROTEIN 1 Authors: Taylor, P, Takeuchi, H, Sheppard, D, Chillakuri, C, Lea, S.M, Haltiwanger, R.S, Handford, P.A. Deposit date: 2014-03-18 Release date: 2014-05-21 Last modified: 2023-12-20 Method: X-RAY DIFFRACTION (3 Å) Cite: Fringe-Mediated Extension of O-Linked Fucose in the Ligand-Binding Region of Notch1 Increases Binding to Mammalian Notch Ligands. Proc.Natl.Acad.Sci.USA, 111, 2014
4D0F	Human Notch1 EGF domains 11-13 mutant T466A Descriptor: 1,2-ETHANEDIOL, CALCIUM ION, NEUROGENIC LOCUS NOTCH HOMOLOG PROTEIN 1 Authors: Taylor, P, Takeuchi, H, Sheppard, D, Chillakuri, C, Lea, S.M, Haltiwanger, R.S, Handford, P.A. Deposit date: 2014-04-25 Release date: 2014-05-21 Last modified: 2023-12-20 Method: X-RAY DIFFRACTION (2.8 Å) Cite: Fringe-Mediated Extension of O-Linked Fucose in the Ligand-Binding Region of Notch1 Increases Binding to Mammalian Notch Ligands. Proc.Natl.Acad.Sci.USA, 111, 2014
4CUF	Human Notch1 EGF domains 11-13 mutant T466S Descriptor: 1,2-ETHANEDIOL, CALCIUM ION, NEUROGENIC LOCUS NOTCH HOMOLOG PROTEIN 1 Authors: Taylor, P, Takeuchi, H, Sheppard, D, Chillakuri, C, Lea, S.M, Haltiwanger, R.S, Handford, P.A. Deposit date: 2014-03-18 Release date: 2014-05-14 Last modified: 2023-12-20 Method: X-RAY DIFFRACTION (2.29 Å) Cite: Fringe-Mediated Extension of O-Linked Fucose in the Ligand-Binding Region of Notch1 Increases Binding to Mammalian Notch Ligands. Proc.Natl.Acad.Sci.USA, 111, 2014
6YAA	Structure of the (SR) Ca2+-ATPase bound to the inhibitor compound CAD204520 and TNP-ATP Descriptor: 4-[2-[(2~{R})-2-[3-propyl-6-(trifluoromethyloxy)-1~{H}-indol-2-yl]piperidin-1-yl]ethyl]morpholine, POTASSIUM ION, SPIRO(2,4,6-TRINITROBENZENE[1,2A]-2O',3O'-METHYLENE-ADENINE-TRIPHOSPHATE, ... Authors: Heit, S, Marchesini, M, Gherli, A, Montanaro, A, Patrizi, L, Sorrentino, C, Pagliaro, L, Rompietti, C, Kitara, S, Olesen, C.E, Moller, J.V, Savi, M, Bocchi, L, Vilella, R, Rizzi, F, Baglione, M, Rastelli, G, Loiacona, C, La Starza, R, Mecucci, C, Stegmair, K, Aversa, F, Stilli, D, Lund Winther, A.M, Sportoletti, P, Dalby-Brown, W, Roti, G, Bublitz, M. Deposit date: 2020-03-11 Release date: 2020-05-20 Last modified: 2024-01-24 Method: X-RAY DIFFRACTION (3.4 Å) Cite: Blockade of Oncogenic NOTCH1 with the SERCA Inhibitor CAD204520 in T Cell Acute Lymphoblastic Leukemia. Cell Chem Biol, 27, 2020
5FMA	human Notch 1, EGF 4-7 Descriptor: 1,2-ETHANEDIOL, CALCIUM ION, CHLORIDE ION, ... Authors: Weisshuhn, P.C, Sheppard, D, Taylor, P, Whiteman, P, Lea, S.M, Handford, P.A, Redfield, C. Deposit date: 2015-11-02 Release date: 2016-04-13 Last modified: 2024-01-10 Method: X-RAY DIFFRACTION (2.46 Å) Cite: Non-Linear and Flexible Regions of the Human Notch1 Extracellular Domain Revealed by High-Resolution Structural Studies. Structure, 24, 2016
5FM9	human Notch 1, EGF 4-7 Descriptor: CALCIUM ION, NEUROGENIC LOCUS NOTCH HOMOLOG PROTEIN 1 Authors: Weisshuhn, P.C, Sheppard, D, Taylor, P, Whiteman, P, Lea, S.M, Handford, P.A, Redfield, C. Deposit date: 2015-11-02 Release date: 2016-04-20 Last modified: 2024-01-10 Method: X-RAY DIFFRACTION (2.92 Å) Cite: Non-Linear and Flexible Regions of the Human Notch1 Extracellular Domain Revealed by High-Resolution Structural Studies. Structure, 24, 2016
7ABV	Structure of the S1-cleaved mouse Notch1 Negative Regulatory Region (NRR) Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, Neurogenic locus notch homolog protein 1 Authors: Zeronian, M.R, Janssen, B.J.C. Deposit date: 2020-09-08 Release date: 2021-07-07 Last modified: 2024-01-31 Method: X-RAY DIFFRACTION (2.065 Å) Cite: Notch-Jagged signaling complex defined by an interaction mosaic. Proc.Natl.Acad.Sci.USA, 118, 2021
3L95	Crystal structure of the human Notch1 Negative Regulatory Region (NRR) bound to the fab fragment of an antagonist antibody Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, Neurogenic locus notch homolog protein 1, ... Authors: Hymowitz, S.G, de Leon, G.P. Deposit date: 2010-01-04 Release date: 2010-03-09 Last modified: 2023-09-06 Method: X-RAY DIFFRACTION (2.19 Å) Cite: Therapeutic antibody targeting of individual Notch receptors. Nature, 464, 2010
6PY8	Crystal structure of the RBPJ-NOTCH1-NRARP ternary complex bound to DNA Descriptor: DNA, Neurogenic locus notch homolog protein 1, Notch-regulated ankyrin repeat-containing protein, ... Authors: Jarrett, S.M, Seegar, T.C.M, Blacklow, S.C. Deposit date: 2019-07-29 Release date: 2019-08-14 Last modified: 2023-10-11 Method: X-RAY DIFFRACTION (3.75 Å) Cite: Extension of the Notch intracellular domain ankyrin repeat stack by NRARP promotes feedback inhibition of Notch signaling. Sci.Signal., 12, 2019
5UK5	Complex of Notch1(EGF8-12) bound to Jagged1(N-EGF3) Descriptor: 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, 2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, ... Authors: Garcia, K.C, Luca, V.C. Deposit date: 2017-01-19 Release date: 2017-03-08 Last modified: 2023-10-04 Method: X-RAY DIFFRACTION (2.506 Å) Cite: Notch-Jagged complex structure implicates a catch bond in tuning ligand sensitivity. Science, 355, 2017
8ORZ	Solution NMR structure of Notch1 G1740-1743 TMD Descriptor: Notch 1 extracellular truncation Authors: Guschtschin-Schmidt, N, Muhle-Goll, C. Deposit date: 2023-04-17 Release date: 2023-08-16 Last modified: 2023-08-23 Method: SOLUTION NMR Cite: Permissive Conformations of a Transmembrane Helix Allow Intramembrane Proteolysis by gamma-Secretase. J.Mol.Biol., 435, 2023
8OR5	Solution NMR structure of Notch1 TMD Descriptor: Notch 1 extracellular truncation Authors: Guschtschin-Schmidt, N, Muhle-Goll, C. Deposit date: 2023-04-13 Release date: 2023-08-16 Last modified: 2023-08-23 Method: SOLUTION NMR Cite: Permissive Conformations of a Transmembrane Helix Allow Intramembrane Proteolysis by gamma-Secretase. J.Mol.Biol., 435, 2023
8ORY	Solution NMR structure of Notch1 L1740-1743 TMD Descriptor: Notch 1 extracellular truncation Authors: Guschtschin-Schmidt, N, Muhle-Goll, C. Deposit date: 2023-04-17 Release date: 2023-08-16 Last modified: 2023-08-23 Method: SOLUTION NMR Cite: Permissive Conformations of a Transmembrane Helix Allow Intramembrane Proteolysis by gamma-Secretase. J.Mol.Biol., 435, 2023
2F8Y	Crystal structure of human Notch1 ankyrin repeats to 1.55A resolution. Descriptor: Notch homolog 1, translocation-associated (Drosophila), SULFATE ION Authors: Nam, Y, Sliz, P, Blacklow, S.C. Deposit date: 2005-12-04 Release date: 2006-04-04 Last modified: 2023-08-30 Method: X-RAY DIFFRACTION (1.55 Å) Cite: Structural basis for cooperativity in recruitment of MAML coactivators to Notch transcription complexes. Cell(Cambridge,Mass.), 124, 2006
5KZO	Notch1 transmembrane and associated juxtamembrane segment Descriptor: Neurogenic locus notch homolog protein 1 Authors: Deatherage, C.L, Lu, Z, Kroncke, B. Deposit date: 2016-07-25 Release date: 2017-05-10 Last modified: 2019-12-25 Method: SOLUTION NMR Cite: Structural and biochemical differences between the Notch and the amyloid precursor protein transmembrane domains. Sci Adv, 3, 2017
6IDF	Cryo-EM structure of gamma secretase in complex with a Notch fragment Descriptor: 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... Authors: Yang, G, Zhou, R, Zhou, Q, Guo, X, Yan, C, Ke, M, Lei, J, Shi, Y. Deposit date: 2018-09-09 Release date: 2018-12-26 Last modified: 2020-07-29 Method: ELECTRON MICROSCOPY (2.7 Å) Cite: Structural basis of Notch recognition by human gamma-secretase Nature, 565, 2019

 

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