3I08

Crystal structure of the S1-cleaved Notch1 Negative Regulatory Region (NRR)

Summary for 3I08

• Entry DOI: 10.2210/pdb3i08/pdb
• Related: 2oo4 3eto
• Descriptor: Neurogenic locus notch homolog protein 1, CALCIUM ION, CHLORIDE ION, ... (5 entities in total)
• Functional Keywords: sea domain, lin-12 notch repeat, lnr, heterodimerization domain, hd, activator, ank repeat, calcium, cell membrane, developmental protein, differentiation, disulfide bond, egf-like domain, glycoprotein, membrane, metal-binding, notch signaling pathway, nucleus, phosphoprotein, polymorphism, receptor, transcription, transcription regulation, transmembrane, furin, t-all, leukemia, oncogene, metalloprotease, gamma-secretase, signaling protein
• Biological source: Homo sapiens (human); More
• Cellular location: Cell membrane; Single-pass type I membrane protein (By similarity). Notch 1 intracellular domain: Nucleus (By similarity): P46531 P46531
• Total number of polymer chains: 4
• Total formula weight: 64233.06

Authors

Gordon, W.R.,Blacklow, S.C. (deposition date: 2009-06-24, release date: 2009-09-01, Last modification date: 2023-09-06)

• Primary citation: Gordon, W.R.,Vardar-Ulu, D.,L'Heureux, S.,Ashworth, T.,Malecki, M.J.,Sanchez-Irizarry, C.,McArthur, D.G.,Histen, G.,Mitchell, J.L.,Aster, J.C.,Blacklow, S.C.; Effects of S1 cleavage on the structure, surface export, and signaling activity of human Notch1 and Notch2.; Plos One, 4:e6613-e6613, 2009; PubMed: 19701457; DOI: 10.1371/journal.pone.0006613

Experimental method

X-RAY DIFFRACTION (3.2 Å)