3L95

Crystal structure of the human Notch1 Negative Regulatory Region (NRR) bound to the fab fragment of an antagonist antibody

Summary for 3L95

• Entry DOI: 10.2210/pdb3l95/pdb
• Related: 2OO4 3ETO
• Descriptor: anti-NRR1 fab fragment light chain, anti-NRR1 fab fragment heavy chain, Neurogenic locus notch homolog protein 1, ... (7 entities in total)
• Functional Keywords: nrr, fab fragment, antibody, alpha-beta-sandwich, sea domain, lnr, lin12 notch cysteine-rich, hd domain, cell cycle, signaling protein, activator, ank repeat, cell membrane, developmental protein, differentiation, egf-like domain, glycoprotein, membrane, metal-binding, notch signaling pathway, immune system
• Biological source: Homo sapiens (human); More
• Total number of polymer chains: 6
• Total formula weight: 150120.83

Authors

Hymowitz, S.G.,de Leon, G.P. (deposition date: 2010-01-04, release date: 2010-03-09, Last modification date: 2023-09-06)

• Primary citation: Wu, Y.,Cain-Hom, C.,Choy, L.,Hagenbeek, T.J.,de Leon, G.P.,Chen, Y.,Finkle, D.,Venook, R.,Wu, X.,Ridgway, J.,Schahin-Reed, D.,Dow, G.J.,Shelton, A.,Stawicki, S.,Watts, R.J.,Zhang, J.,Choy, R.,Howard, P.,Kadyk, L.,Yan, M.,Zha, J.,Callahan, C.A.,Hymowitz, S.G.,Siebel, C.W.; Therapeutic antibody targeting of individual Notch receptors.; Nature, 464:1052-1057, 2010; PubMed: 20393564; DOI: 10.1038/nature08878

Experimental method

X-RAY DIFFRACTION (2.19 Å)