3ETO
2 Angstrom Xray structure of the NOTCH1 Negative Regulatory Region (NRR)
Summary for 3ETO
Entry DOI | 10.2210/pdb3eto/pdb |
Descriptor | Neurogenic locus notch homolog protein 1, CALCIUM ION, CHLORIDE ION, ... (5 entities in total) |
Functional Keywords | alpha-beta sandwich, hd domain, lnr repeat, calcium-binding, sea domain, autoinhibition, activator, t-all, leukemia, oncogene, ank repeat, developmental protein, differentiation, egf-like domain, glycoprotein, membrane, metal-binding, notch signaling pathway, nucleus, phosphoprotein, receptor, transcription, transcription regulation, transmembrane, signaling protein |
Biological source | Homo sapiens |
Cellular location | Cell membrane; Single-pass type I membrane protein (By similarity). Notch 1 intracellular domain: Nucleus (By similarity): P46531 |
Total number of polymer chains | 2 |
Total formula weight | 54541.45 |
Authors | Gordon, W.R.,Blacklow, S.C. (deposition date: 2008-10-08, release date: 2008-12-23, Last modification date: 2023-09-06) |
Primary citation | Gordon, W.R.,Roy, M.,Vardar-Ulu, D.,Garfinkel, M.,Mansour, M.R.,Aster, J.C.,Blacklow, S.C. Structure of the Notch1-negative regulatory region: implications for normal activation and pathogenic signaling in T-ALL. Blood, 113:4381-4390, 2009 Cited by PubMed: 19075186DOI: 10.1182/blood-2008-08-174748 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2 Å) |
Structure validation
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