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1CSY
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BU of 1csy by Molmil
SYK TYROSINE KINASE C-TERMINAL SH2 DOMAIN COMPLEXED WITH A PHOSPHOPEPTIDEFROM THE GAMMA CHAIN OF THE HIGH AFFINITY IMMUNOGLOBIN G RECEPTOR, NMR
Descriptor: ACETYL-THR-PTR-GLU-THR-LEU-NH2, SYK PROTEIN TYROSINE KINASE
Authors:Narula, S.S, Yuan, R.W, Adams, S.E, Green, O.M, Green, J, Phillips, T.B, Zydowsky, L.D, Botfield, M.C, Hatada, M.H, Laird, E.R, Zoller, M.J, Karas, J.L, Dalgarno, D.C.
Deposit date:1995-10-03
Release date:1996-11-08
Last modified:2024-06-05
Method:SOLUTION NMR
Cite:Solution structure of the C-terminal SH2 domain of the human tyrosine kinase Syk complexed with a phosphotyrosine pentapeptide.
Structure, 3, 1995
1CWE
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BU of 1cwe by Molmil
HUMAN P56LCK TYROSINE KINASE COMPLEXED WITH PHOSPHOPEPTIDE
Descriptor: P56LCK TYROSINE KINASE, PHOSPHOPEPTIDE ACQ-PMP-GLU-GLU-ILE-PRO
Authors:Mikol, V.
Deposit date:1995-09-06
Release date:1996-12-07
Last modified:2024-06-05
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:The crystal structures of the SH2 domain of p56lck complexed with two phosphopeptides suggest a gated peptide binding site.
J.Mol.Biol., 246, 1995
1FYR
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BU of 1fyr by Molmil
DIMER FORMATION THROUGH DOMAIN SWAPPING IN THE CRYSTAL STRUCTURE OF THE GRB2-SH2 AC-PYVNV COMPLEX
Descriptor: GROWTH FACTOR RECEPTOR-BOUND PROTEIN 2, HEPATOCYTE GROWTH FACTOR RECEPTOR PEPTIDE
Authors:Schiering, N, Casale, E, Caccia, P, Giordano, P, Battistini, C.
Deposit date:2000-10-03
Release date:2000-12-06
Last modified:2023-11-15
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Dimer formation through domain swapping in the crystal structure of the Grb2-SH2-Ac-pYVNV complex.
Biochemistry, 39, 2000
1JWO
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Crystal Structure Analysis of the SH2 Domain of the Csk Homologous Kinase CHK
Descriptor: Csk Homologous Kinase
Authors:Murthy, T.V.S, Webster, G.D.
Deposit date:2001-09-04
Release date:2001-09-12
Last modified:2023-08-16
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Recognition of the HER-2/neu Receptor by the SH2 Domain of the Csk Homologous Kinase
To be Published
1GHU
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BU of 1ghu by Molmil
NMR solution structure of growth factor receptor-bound protein 2 (GRB2) SH2 domain, 24 structures
Descriptor: GRB2
Authors:Thornton, K.H, Mueller, W.T, Mcconnell, P, Zhu, G, Saltiel, A.R, Thanabal, V.
Deposit date:1996-08-05
Release date:1997-01-27
Last modified:2024-05-22
Method:SOLUTION NMR
Cite:Nuclear magnetic resonance solution structure of the growth factor receptor-bound protein 2 Src homology 2 domain.
Biochemistry, 35, 1996
1F1W
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SRC SH2 THREF1TRP MUTANT COMPLEXED WITH THE PHOSPHOPEPTIDE S(PTR)VNVQN
Descriptor: PROTO-ONCOGENE TYROSINE-PROTEIN KINASE SRC, S(PTR)VNVQN PHOSPHOPEPTIDE
Authors:Kimber, M.S, Nachman, J, Cunningham, A.M, Gish, G.D, Pawson, T, Pai, E.F.
Deposit date:2000-05-20
Release date:2000-07-06
Last modified:2023-11-15
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Structural basis for specificity switching of the Src SH2 domain.
Mol.Cell, 5, 2000
1LKL
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HUMAN P56-LCK TYROSINE KINASE SH2 DOMAIN IN COMPLEX WITH THE PHOSPHOTYROSYL PEPTIDE AC-PTYR-GLU-GLU-GLY (PYEEG PEPTIDE)
Descriptor: HUMAN P56 TYROSINE KINASE, PHOSPHOTYROSYL PEPTIDE AC-PTYR-GLU-GLU-GLY
Authors:Tong, L.
Deposit date:1995-11-10
Release date:1996-03-08
Last modified:2024-06-05
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Crystal structures of the human p56lck SH2 domain in complex with two short phosphotyrosyl peptides at 1.0 A and 1.8 A resolution.
J.Mol.Biol., 256, 1996
1LCJ
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SH2 (SRC HOMOLOGY-2) DOMAIN OF HUMAN P56-LCK TYROSINE KINASE COMPLEXED WITH THE 11 RESIDUE PHOSPHOTYROSYL PEPTIDE EPQPYEEIPIYL
Descriptor: P56==LCK== TYROSINE KINASE, PHOSPHOPEPTIDE EPQ(PHOSPHO)YEEIPIYL
Authors:Eck, M, Harrison, S.
Deposit date:1994-12-12
Release date:1995-10-15
Last modified:2024-06-05
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Recognition of a high-affinity phosphotyrosyl peptide by the Src homology-2 domain of p56lck.
Nature, 362, 1993
1LUI
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BU of 1lui by Molmil
NMR Structures of Itk SH2 domain, Pro287cis isoform, ensemble of 20 low energy structures
Descriptor: Tyrosine-protein kinase ITK/TSK
Authors:Mallis, R.J, Brazin, K.N, Fulton, B.F, Andreotti, A.M.
Deposit date:2002-05-22
Release date:2002-11-27
Last modified:2022-02-23
Method:SOLUTION NMR
Cite:Structural characterization of a proline-driven conformational switch within the Itk SH2 domain
Nat.Struct.Biol., 9, 2002
1LUK
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NMR Structure of the Itk SH2 domain, Pro287cis, Energy minimized average structure
Descriptor: Tyrosine-protein kinase ITK/TSK
Authors:Mallis, R.J, Brazin, K.N, Fulton, B.F, Andreotti, A.H.
Deposit date:2002-05-22
Release date:2002-11-27
Last modified:2022-02-23
Method:SOLUTION NMR
Cite:Structural characterization of a proline-driven conformational switch within the Itk SH2 domain
Nat.Struct.Biol., 9, 2002
1LUN
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NMR Structure of the Itk SH2 domain, Pro287trans, energy minimized average structure
Descriptor: Tyrosine-protein kinase ITK/TSK
Authors:Mallis, R.J, Brazin, K.N, Fulton, D.B, Andreotti, A.H.
Deposit date:2002-05-22
Release date:2002-11-27
Last modified:2022-02-23
Method:SOLUTION NMR
Cite:Structural characterization of a proline-driven conformational switch within the Itk SH2 domain
Nat.Struct.Biol., 9, 2002
1F2F
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BU of 1f2f by Molmil
SRC SH2 THREF1TRP MUTANT
Descriptor: PHOSPHATE ION, PROTO-ONCOGENE TYROSINE-PROTEIN KINASE SRC
Authors:Kimber, M.S, Nachman, J, Cunningham, A.M, Gish, G.D, Pawson, T, Pai, E.F.
Deposit date:2000-05-24
Release date:2000-07-06
Last modified:2024-02-07
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Structural basis for specificity switching of the Src SH2 domain.
Mol.Cell, 5, 2000
1H9O
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PHOSPHATIDYLINOSITOL 3-KINASE, P85-ALPHA SUBUNIT: C-TERMINAL SH2 DOMAIN COMPLEXED WITH A TYR751 PHOSPHOPEPTIDE FROM THE PDGF RECEPTOR, CRYSTAL STRUCTURE AT 1.79 A
Descriptor: BETA-PLATELET-DERIVED GROWTH FACTOR RECEPTOR, PHOSPHATIDYLINOSITOL 3-KINASE
Authors:Pauptit, R.A, Rowsell, S, Breeze, A.L, Murshudov, G.N, Dennis, C.A, Derbyshire, D.J, Weston, S.A.
Deposit date:2001-03-14
Release date:2001-03-19
Last modified:2023-12-13
Method:X-RAY DIFFRACTION (1.79 Å)
Cite:NMR Trial Models: Experiences with the Colicin Immunity Protein Im7 and the P85Alpha C-Terminal Sh2-Peptide Complex
Acta Crystallogr.,Sect.D, 57, 2001
2GE9
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BU of 2ge9 by Molmil
Solution Structures of the SH2 domain of Bruton's Tyrosine Kinase
Descriptor: Tyrosine-protein kinase BTK
Authors:Cheng, J.-W, Huang, K.-C.
Deposit date:2006-03-18
Release date:2006-10-24
Last modified:2024-05-29
Method:SOLUTION NMR
Cite:Solution structure and phosphopeptide binding of the SH2 domain from the human Bruton's tyrosine kinase
J.Biomol.Nmr, 36, 2006
2HMH
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BU of 2hmh by Molmil
Crystal structure of SOCS3 in complex with gp130(pTyr757) phosphopeptide.
Descriptor: Interleukin-6 receptor beta chain, Suppressor of cytokine signaling 3
Authors:Bergamin, E, Wu, J, Hubbard, S.R.
Deposit date:2006-07-11
Release date:2006-08-15
Last modified:2023-11-15
Method:X-RAY DIFFRACTION (2 Å)
Cite:Structural basis for phosphotyrosine recognition by suppressor of cytokine signaling-3.
Structure, 14, 2006
2IUH
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Crystal structure of the PI3-kinase p85 N-terminal SH2 domain in complex with c-Kit phosphotyrosyl peptide
Descriptor: C-KIT PHOSPHOTYROSYL PEPTIDE, PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY ALPHA SUBUNIT
Authors:Nolte, R.T, Eck, M.J, Schlessinger, J, Shoelson, S.E, Harrison, S.C.
Deposit date:2006-06-03
Release date:2006-06-06
Last modified:2021-04-28
Method:X-RAY DIFFRACTION (2 Å)
Cite:Crystal Structure of the Pi 3-Kinase P85 Amino-Terminal Sh2 Domain and its Phosphopeptide Complexes
Nat.Struct.Biol., 3, 1996
2IUG
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BU of 2iug by Molmil
Crystal structure of the PI3-kinase p85 N-terminal SH2 domain
Descriptor: PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY ALPHA SUBUNIT
Authors:Nolte, R.T, Eck, M.J, Schlessinger, J, Shoelson, S.E, Harrison, S.C.
Deposit date:2006-06-03
Release date:2006-06-06
Last modified:2024-05-08
Method:X-RAY DIFFRACTION (1.89 Å)
Cite:Crystal Structure of the Pi 3-Kinase P85 Amino-Terminal Sh2 Domain and its Phosphopeptide Complexes
Nat.Struct.Biol., 3, 1996
2IUI
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Crystal structure of the PI3-kinase p85 N-terminal SH2 domain in complex with PDGFR phosphotyrosyl peptide
Descriptor: Phosphatidylinositol 3-kinase regulatory subunit alpha, Platelet-derived growth factor receptor beta
Authors:Nolte, R.T, Eck, M.J, Schlessinger, J, Shoelson, S.E, Harrison, S.C.
Deposit date:2006-06-03
Release date:2006-06-06
Last modified:2021-04-28
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Crystal Structure of the Pi 3-Kinase P85 Amino- Terminal Sh2 Domain and its Phosphopeptide Complexes
Nat.Struct.Biol., 3, 1996
2FCI
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Structural basis for the requirement of two phosphotyrosines in signaling mediated by Syk tyrosine kinase
Descriptor: C-termainl SH2 domain from phospholipase C-gamma-1 comprising residues 663-759, Doubly phosphorylated peptide derived from Syk kinase comprising residues 338-350
Authors:Groesch, T.D, Zhou, F, Mattila, S, Geahlen, R.L, Post, C.B.
Deposit date:2005-12-12
Release date:2006-01-31
Last modified:2023-11-15
Method:SOLUTION NMR
Cite:Structural basis for the requirement of two phosphotyrosine residues in signaling mediated by syk tyrosine kinase
J.Mol.Biol., 356, 2006
2HDV
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Crystal structure of the Src Homology-2 domain of the adapter protein SH2-B
Descriptor: SH2-B PH domain containing signaling mediator 1 gamma isoform
Authors:Hu, J, Hubbard, S.R.
Deposit date:2006-06-20
Release date:2006-08-08
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (2 Å)
Cite:Structural Basis for Phosphotyrosine Recognition by the Src Homology-2 Domains of the Adapter Proteins SH2-B and APS.
J.Mol.Biol., 361, 2006
2H46
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Native domain-swapped dimer crystal structure of the Grb2 SH2 domain
Descriptor: GLYCEROL, Growth Receptor Binding Protein 2
Authors:Benfield, A.P, Martin, S.F, Whiddon, B.B.
Deposit date:2006-05-23
Release date:2006-06-06
Last modified:2024-02-14
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Structural and energetic aspects of Grb2-SH2 domain-swapping.
Arch.Biochem.Biophys., 462, 2007
2HDX
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Crystal structure of the Src homology-2 domain of SH2-B in complex with Jak2 pTyr813 phosphopeptide
Descriptor: Jak2 protein, SH2-B PH domain containing signaling mediator 1 gamma isoform
Authors:Hu, J, Hubbard, S.R.
Deposit date:2006-06-21
Release date:2006-08-08
Last modified:2023-11-15
Method:X-RAY DIFFRACTION (2.35 Å)
Cite:Structural Basis for Phosphotyrosine Recognition by the Src Homology-2 Domains of the Adapter Proteins SH2-B and APS.
J.Mol.Biol., 361, 2006
2GSB
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Solution structure of the second SH2 domain of human Ras GTPase-activating protein 1
Descriptor: Ras GTPase-activating protein 1
Authors:Kurosaki, C, Suetake, T, Yoshida, M, Hayashi, F, Yokoyma, S, RIKEN Structural Genomics/Proteomics Initiative (RSGI)
Deposit date:2006-04-26
Release date:2007-05-01
Last modified:2024-05-29
Method:SOLUTION NMR
Cite:Solution structure of the second SH2 domain of human Ras GTPase-activating protein 1
To be Published
2HUW
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X-ray crystal structure of the Grb2 SH2 domain complexed to a constrained and cyclopropane-derived ligand
Descriptor: Growth factor receptor-bound protein 2, N-({(1R,2R,3S)-2-(methylcarbamoyl)-3-[4-(phosphonooxy)phenyl]cyclopropyl}carbonyl)-L-valyl-L-aspartamide, PHOSPHATE ION
Authors:Benfield, A.P, Martin, S.F.
Deposit date:2006-07-27
Release date:2006-08-15
Last modified:2024-02-14
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Ligand Preorganization May Be Accompanied by Entropic Penalties in Protein-Ligand Interactions.
Angew.Chem.Int.Ed.Engl., 45, 2006
2JYQ
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NMR structure of the apo v-Src SH2 domain
Descriptor: Tyrosine-protein kinase transforming protein Src
Authors:Taylor, J.D, Ababou, A, Williams, M.A, Ladbury, J.E.
Deposit date:2007-12-17
Release date:2008-06-24
Last modified:2024-05-29
Method:SOLUTION NMR
Cite:Structure, dynamics, and binding thermodynamics of the v-Src SH2 domain: Implications for drug design
Proteins, 73, 2008

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