PDB: 595 resultsInfo pagesStatus searchChemie searchBIRD

---

1CSY	SYK TYROSINE KINASE C-TERMINAL SH2 DOMAIN COMPLEXED WITH A PHOSPHOPEPTIDEFROM THE GAMMA CHAIN OF THE HIGH AFFINITY IMMUNOGLOBIN G RECEPTOR, NMR Descriptor: ACETYL-THR-PTR-GLU-THR-LEU-NH2, SYK PROTEIN TYROSINE KINASE Authors: Narula, S.S, Yuan, R.W, Adams, S.E, Green, O.M, Green, J, Phillips, T.B, Zydowsky, L.D, Botfield, M.C, Hatada, M.H, Laird, E.R, Zoller, M.J, Karas, J.L, Dalgarno, D.C. Deposit date: 1995-10-03 Release date: 1996-11-08 Last modified: 2024-06-05 Method: SOLUTION NMR Cite: Solution structure of the C-terminal SH2 domain of the human tyrosine kinase Syk complexed with a phosphotyrosine pentapeptide. Structure, 3, 1995
1CWE	HUMAN P56LCK TYROSINE KINASE COMPLEXED WITH PHOSPHOPEPTIDE Descriptor: P56LCK TYROSINE KINASE, PHOSPHOPEPTIDE ACQ-PMP-GLU-GLU-ILE-PRO Authors: Mikol, V. Deposit date: 1995-09-06 Release date: 1996-12-07 Last modified: 2024-06-05 Method: X-RAY DIFFRACTION (2.3 Å) Cite: The crystal structures of the SH2 domain of p56lck complexed with two phosphopeptides suggest a gated peptide binding site. J.Mol.Biol., 246, 1995
1FYR	DIMER FORMATION THROUGH DOMAIN SWAPPING IN THE CRYSTAL STRUCTURE OF THE GRB2-SH2 AC-PYVNV COMPLEX Descriptor: GROWTH FACTOR RECEPTOR-BOUND PROTEIN 2, HEPATOCYTE GROWTH FACTOR RECEPTOR PEPTIDE Authors: Schiering, N, Casale, E, Caccia, P, Giordano, P, Battistini, C. Deposit date: 2000-10-03 Release date: 2000-12-06 Last modified: 2023-11-15 Method: X-RAY DIFFRACTION (2.4 Å) Cite: Dimer formation through domain swapping in the crystal structure of the Grb2-SH2-Ac-pYVNV complex. Biochemistry, 39, 2000
1JWO	Crystal Structure Analysis of the SH2 Domain of the Csk Homologous Kinase CHK Descriptor: Csk Homologous Kinase Authors: Murthy, T.V.S, Webster, G.D. Deposit date: 2001-09-04 Release date: 2001-09-12 Last modified: 2023-08-16 Method: X-RAY DIFFRACTION (2.5 Å) Cite: Recognition of the HER-2/neu Receptor by the SH2 Domain of the Csk Homologous Kinase To be Published
1GHU	NMR solution structure of growth factor receptor-bound protein 2 (GRB2) SH2 domain, 24 structures Descriptor: GRB2 Authors: Thornton, K.H, Mueller, W.T, Mcconnell, P, Zhu, G, Saltiel, A.R, Thanabal, V. Deposit date: 1996-08-05 Release date: 1997-01-27 Last modified: 2024-05-22 Method: SOLUTION NMR Cite: Nuclear magnetic resonance solution structure of the growth factor receptor-bound protein 2 Src homology 2 domain. Biochemistry, 35, 1996
1F1W	SRC SH2 THREF1TRP MUTANT COMPLEXED WITH THE PHOSPHOPEPTIDE S(PTR)VNVQN Descriptor: PROTO-ONCOGENE TYROSINE-PROTEIN KINASE SRC, S(PTR)VNVQN PHOSPHOPEPTIDE Authors: Kimber, M.S, Nachman, J, Cunningham, A.M, Gish, G.D, Pawson, T, Pai, E.F. Deposit date: 2000-05-20 Release date: 2000-07-06 Last modified: 2023-11-15 Method: X-RAY DIFFRACTION (2.1 Å) Cite: Structural basis for specificity switching of the Src SH2 domain. Mol.Cell, 5, 2000
1LKL	HUMAN P56-LCK TYROSINE KINASE SH2 DOMAIN IN COMPLEX WITH THE PHOSPHOTYROSYL PEPTIDE AC-PTYR-GLU-GLU-GLY (PYEEG PEPTIDE) Descriptor: HUMAN P56 TYROSINE KINASE, PHOSPHOTYROSYL PEPTIDE AC-PTYR-GLU-GLU-GLY Authors: Tong, L. Deposit date: 1995-11-10 Release date: 1996-03-08 Last modified: 2024-06-05 Method: X-RAY DIFFRACTION (1.8 Å) Cite: Crystal structures of the human p56lck SH2 domain in complex with two short phosphotyrosyl peptides at 1.0 A and 1.8 A resolution. J.Mol.Biol., 256, 1996
1LCJ	SH2 (SRC HOMOLOGY-2) DOMAIN OF HUMAN P56-LCK TYROSINE KINASE COMPLEXED WITH THE 11 RESIDUE PHOSPHOTYROSYL PEPTIDE EPQPYEEIPIYL Descriptor: P56==LCK== TYROSINE KINASE, PHOSPHOPEPTIDE EPQ(PHOSPHO)YEEIPIYL Authors: Eck, M, Harrison, S. Deposit date: 1994-12-12 Release date: 1995-10-15 Last modified: 2024-06-05 Method: X-RAY DIFFRACTION (1.8 Å) Cite: Recognition of a high-affinity phosphotyrosyl peptide by the Src homology-2 domain of p56lck. Nature, 362, 1993
1LUI	NMR Structures of Itk SH2 domain, Pro287cis isoform, ensemble of 20 low energy structures Descriptor: Tyrosine-protein kinase ITK/TSK Authors: Mallis, R.J, Brazin, K.N, Fulton, B.F, Andreotti, A.M. Deposit date: 2002-05-22 Release date: 2002-11-27 Last modified: 2022-02-23 Method: SOLUTION NMR Cite: Structural characterization of a proline-driven conformational switch within the Itk SH2 domain Nat.Struct.Biol., 9, 2002
1LUK	NMR Structure of the Itk SH2 domain, Pro287cis, Energy minimized average structure Descriptor: Tyrosine-protein kinase ITK/TSK Authors: Mallis, R.J, Brazin, K.N, Fulton, B.F, Andreotti, A.H. Deposit date: 2002-05-22 Release date: 2002-11-27 Last modified: 2022-02-23 Method: SOLUTION NMR Cite: Structural characterization of a proline-driven conformational switch within the Itk SH2 domain Nat.Struct.Biol., 9, 2002
1LUN	NMR Structure of the Itk SH2 domain, Pro287trans, energy minimized average structure Descriptor: Tyrosine-protein kinase ITK/TSK Authors: Mallis, R.J, Brazin, K.N, Fulton, D.B, Andreotti, A.H. Deposit date: 2002-05-22 Release date: 2002-11-27 Last modified: 2022-02-23 Method: SOLUTION NMR Cite: Structural characterization of a proline-driven conformational switch within the Itk SH2 domain Nat.Struct.Biol., 9, 2002
1F2F	SRC SH2 THREF1TRP MUTANT Descriptor: PHOSPHATE ION, PROTO-ONCOGENE TYROSINE-PROTEIN KINASE SRC Authors: Kimber, M.S, Nachman, J, Cunningham, A.M, Gish, G.D, Pawson, T, Pai, E.F. Deposit date: 2000-05-24 Release date: 2000-07-06 Last modified: 2024-02-07 Method: X-RAY DIFFRACTION (1.7 Å) Cite: Structural basis for specificity switching of the Src SH2 domain. Mol.Cell, 5, 2000
1H9O	PHOSPHATIDYLINOSITOL 3-KINASE, P85-ALPHA SUBUNIT: C-TERMINAL SH2 DOMAIN COMPLEXED WITH A TYR751 PHOSPHOPEPTIDE FROM THE PDGF RECEPTOR, CRYSTAL STRUCTURE AT 1.79 A Descriptor: BETA-PLATELET-DERIVED GROWTH FACTOR RECEPTOR, PHOSPHATIDYLINOSITOL 3-KINASE Authors: Pauptit, R.A, Rowsell, S, Breeze, A.L, Murshudov, G.N, Dennis, C.A, Derbyshire, D.J, Weston, S.A. Deposit date: 2001-03-14 Release date: 2001-03-19 Last modified: 2023-12-13 Method: X-RAY DIFFRACTION (1.79 Å) Cite: NMR Trial Models: Experiences with the Colicin Immunity Protein Im7 and the P85Alpha C-Terminal Sh2-Peptide Complex Acta Crystallogr.,Sect.D, 57, 2001
2GE9	Solution Structures of the SH2 domain of Bruton's Tyrosine Kinase Descriptor: Tyrosine-protein kinase BTK Authors: Cheng, J.-W, Huang, K.-C. Deposit date: 2006-03-18 Release date: 2006-10-24 Last modified: 2024-05-29 Method: SOLUTION NMR Cite: Solution structure and phosphopeptide binding of the SH2 domain from the human Bruton's tyrosine kinase J.Biomol.Nmr, 36, 2006
2HMH	Crystal structure of SOCS3 in complex with gp130(pTyr757) phosphopeptide. Descriptor: Interleukin-6 receptor beta chain, Suppressor of cytokine signaling 3 Authors: Bergamin, E, Wu, J, Hubbard, S.R. Deposit date: 2006-07-11 Release date: 2006-08-15 Last modified: 2023-11-15 Method: X-RAY DIFFRACTION (2 Å) Cite: Structural basis for phosphotyrosine recognition by suppressor of cytokine signaling-3. Structure, 14, 2006
2IUH	Crystal structure of the PI3-kinase p85 N-terminal SH2 domain in complex with c-Kit phosphotyrosyl peptide Descriptor: C-KIT PHOSPHOTYROSYL PEPTIDE, PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY ALPHA SUBUNIT Authors: Nolte, R.T, Eck, M.J, Schlessinger, J, Shoelson, S.E, Harrison, S.C. Deposit date: 2006-06-03 Release date: 2006-06-06 Last modified: 2021-04-28 Method: X-RAY DIFFRACTION (2 Å) Cite: Crystal Structure of the Pi 3-Kinase P85 Amino-Terminal Sh2 Domain and its Phosphopeptide Complexes Nat.Struct.Biol., 3, 1996
2IUG	Crystal structure of the PI3-kinase p85 N-terminal SH2 domain Descriptor: PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY ALPHA SUBUNIT Authors: Nolte, R.T, Eck, M.J, Schlessinger, J, Shoelson, S.E, Harrison, S.C. Deposit date: 2006-06-03 Release date: 2006-06-06 Last modified: 2024-05-08 Method: X-RAY DIFFRACTION (1.89 Å) Cite: Crystal Structure of the Pi 3-Kinase P85 Amino-Terminal Sh2 Domain and its Phosphopeptide Complexes Nat.Struct.Biol., 3, 1996
2IUI	Crystal structure of the PI3-kinase p85 N-terminal SH2 domain in complex with PDGFR phosphotyrosyl peptide Descriptor: Phosphatidylinositol 3-kinase regulatory subunit alpha, Platelet-derived growth factor receptor beta Authors: Nolte, R.T, Eck, M.J, Schlessinger, J, Shoelson, S.E, Harrison, S.C. Deposit date: 2006-06-03 Release date: 2006-06-06 Last modified: 2021-04-28 Method: X-RAY DIFFRACTION (2.4 Å) Cite: Crystal Structure of the Pi 3-Kinase P85 Amino- Terminal Sh2 Domain and its Phosphopeptide Complexes Nat.Struct.Biol., 3, 1996
2FCI	Structural basis for the requirement of two phosphotyrosines in signaling mediated by Syk tyrosine kinase Descriptor: C-termainl SH2 domain from phospholipase C-gamma-1 comprising residues 663-759, Doubly phosphorylated peptide derived from Syk kinase comprising residues 338-350 Authors: Groesch, T.D, Zhou, F, Mattila, S, Geahlen, R.L, Post, C.B. Deposit date: 2005-12-12 Release date: 2006-01-31 Last modified: 2023-11-15 Method: SOLUTION NMR Cite: Structural basis for the requirement of two phosphotyrosine residues in signaling mediated by syk tyrosine kinase J.Mol.Biol., 356, 2006
2HDV	Crystal structure of the Src Homology-2 domain of the adapter protein SH2-B Descriptor: SH2-B PH domain containing signaling mediator 1 gamma isoform Authors: Hu, J, Hubbard, S.R. Deposit date: 2006-06-20 Release date: 2006-08-08 Last modified: 2023-08-30 Method: X-RAY DIFFRACTION (2 Å) Cite: Structural Basis for Phosphotyrosine Recognition by the Src Homology-2 Domains of the Adapter Proteins SH2-B and APS. J.Mol.Biol., 361, 2006
2H46	Native domain-swapped dimer crystal structure of the Grb2 SH2 domain Descriptor: GLYCEROL, Growth Receptor Binding Protein 2 Authors: Benfield, A.P, Martin, S.F, Whiddon, B.B. Deposit date: 2006-05-23 Release date: 2006-06-06 Last modified: 2024-02-14 Method: X-RAY DIFFRACTION (1.9 Å) Cite: Structural and energetic aspects of Grb2-SH2 domain-swapping. Arch.Biochem.Biophys., 462, 2007
2HDX	Crystal structure of the Src homology-2 domain of SH2-B in complex with Jak2 pTyr813 phosphopeptide Descriptor: Jak2 protein, SH2-B PH domain containing signaling mediator 1 gamma isoform Authors: Hu, J, Hubbard, S.R. Deposit date: 2006-06-21 Release date: 2006-08-08 Last modified: 2023-11-15 Method: X-RAY DIFFRACTION (2.35 Å) Cite: Structural Basis for Phosphotyrosine Recognition by the Src Homology-2 Domains of the Adapter Proteins SH2-B and APS. J.Mol.Biol., 361, 2006
2GSB	Solution structure of the second SH2 domain of human Ras GTPase-activating protein 1 Descriptor: Ras GTPase-activating protein 1 Authors: Kurosaki, C, Suetake, T, Yoshida, M, Hayashi, F, Yokoyma, S, RIKEN Structural Genomics/Proteomics Initiative (RSGI) Deposit date: 2006-04-26 Release date: 2007-05-01 Last modified: 2024-05-29 Method: SOLUTION NMR Cite: Solution structure of the second SH2 domain of human Ras GTPase-activating protein 1 To be Published
2HUW	X-ray crystal structure of the Grb2 SH2 domain complexed to a constrained and cyclopropane-derived ligand Descriptor: Growth factor receptor-bound protein 2, N-({(1R,2R,3S)-2-(methylcarbamoyl)-3-[4-(phosphonooxy)phenyl]cyclopropyl}carbonyl)-L-valyl-L-aspartamide, PHOSPHATE ION Authors: Benfield, A.P, Martin, S.F. Deposit date: 2006-07-27 Release date: 2006-08-15 Last modified: 2024-02-14 Method: X-RAY DIFFRACTION (1.9 Å) Cite: Ligand Preorganization May Be Accompanied by Entropic Penalties in Protein-Ligand Interactions. Angew.Chem.Int.Ed.Engl., 45, 2006
2JYQ	NMR structure of the apo v-Src SH2 domain Descriptor: Tyrosine-protein kinase transforming protein Src Authors: Taylor, J.D, Ababou, A, Williams, M.A, Ladbury, J.E. Deposit date: 2007-12-17 Release date: 2008-06-24 Last modified: 2024-05-29 Method: SOLUTION NMR Cite: Structure, dynamics, and binding thermodynamics of the v-Src SH2 domain: Implications for drug design Proteins, 73, 2008

<12345678910111213141516>