2IUH

Crystal structure of the PI3-kinase p85 N-terminal SH2 domain in complex with c-Kit phosphotyrosyl peptide

Summary for 2IUH

Entry DOI	10.2210/pdb2iuh/pdb
Related	1A0N 1AZG 1H9O 1PBW 1PHT 1PIC 1PKS 1PKT 2IUG 2IUI
Descriptor	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY ALPHA SUBUNIT, C-KIT PHOSPHOTYROSYL PEPTIDE (3 entities in total)
Functional Keywords	transferase, polymorphism, ubl conjugation, phosphorylation, p85, sh2, pi3k, sh2 domain, sh3 domain, pi3-kinase, disease mutation
Biological source	HOMO SAPIENS (HUMAN) More
Total number of polymer chains	2
Total formula weight	15305.01
Authors	Nolte, R.T.,Eck, M.J.,Schlessinger, J.,Shoelson, S.E.,Harrison, S.C. (deposition date: 2006-06-03, release date: 2006-06-06, Last modification date: 2021-04-28)
Primary citation	Nolte, R.T.,Eck, M.J.,Schlessinger, J.,Shoelson, S.E.,Harrison, S.C. Crystal Structure of the Pi 3-Kinase P85 Amino-Terminal Sh2 Domain and its Phosphopeptide Complexes Nat.Struct.Biol., 3:364-, 1996 Cited by PubMed: 8599763 DOI: 10.1038/NSB0496-364 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2 Å)

Structure validation