Loading
PDBj
MenuPDBj@FacebookPDBj@TwitterPDBj@YouTubewwPDB FoundationwwPDB
RCSB PDBPDBeBMRBAdv. SearchSearch help

2HUW

X-ray crystal structure of the Grb2 SH2 domain complexed to a constrained and cyclopropane-derived ligand

Summary for 2HUW
Entry DOI10.2210/pdb2huw/pdb
DescriptorGrowth factor receptor-bound protein 2, N-({(1R,2R,3S)-2-(methylcarbamoyl)-3-[4-(phosphonooxy)phenyl]cyclopropyl}carbonyl)-L-valyl-L-aspartamide, PHOSPHATE ION, ... (4 entities in total)
Functional Keywordscylcopropane, contrained, grb2, sh2, preorganization, hormone-growth factor complex, hormone/growth factor
Biological sourceHomo sapiens (human)
Cellular locationNucleus : P62993
Total number of polymer chains2
Total formula weight28524.83
Authors
Benfield, A.P.,Martin, S.F. (deposition date: 2006-07-27, release date: 2006-08-15, Last modification date: 2024-02-14)
Primary citationBenfield, A.P.,Teresk, M.G.,Plake, H.R.,Delorbe, J.E.,Millspaugh, L.E.,Martin, S.F.
Ligand Preorganization May Be Accompanied by Entropic Penalties in Protein-Ligand Interactions.
Angew.Chem.Int.Ed.Engl., 45:6830-6835, 2006
Cited by
PubMed: 17001728
DOI: 10.1002/anie.200600844
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (1.9 Å)
Structure validation

217705

PDB entries from 2024-03-27

PDB statisticsPDBj update infoContact PDBjnumon