Loading
PDBj
MenuPDBj@FacebookPDBj@TwitterPDBj@YouTubewwPDB FoundationwwPDB
RCSB PDBPDBeBMRBAdv. SearchSearch help

1FDT
DownloadVisualize
BU of 1fdt by Molmil
HUMAN 17-BETA-HYDROXYSTEROID-DEHYDROGENASE TYPE 1 COMPLEXED WITH ESTRADIOL AND NADP+
Descriptor: 17-BETA-HYDROXYSTEROID-DEHYDROGENASE, ESTRADIOL, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, ...
Authors:Housset, D, Breton, R, Mazza, C, Fontecilla-Camps, J.-C.
Deposit date:1996-06-28
Release date:1997-02-12
Last modified:2024-06-05
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:The structure of a complex of human 17beta-hydroxysteroid dehydrogenase with estradiol and NADP+ identifies two principal targets for the design of inhibitors.
Structure, 4, 1996
1FMC
DownloadVisualize
BU of 1fmc by Molmil
7-ALPHA-HYDROXYSTEROID DEHYDROGENASE COMPLEX WITH NADH AND 7-OXO GLYCOCHENODEOXYCHOLIC ACID
Descriptor: 1,4-DIHYDRONICOTINAMIDE ADENINE DINUCLEOTIDE, 7 ALPHA-HYDROXYSTEROID DEHYDROGENASE, GLYCOCHENODEOXYCHOLIC ACID
Authors:Tanaka, N, Nonaka, T, Mitsui, Y.
Deposit date:1996-04-26
Release date:1996-11-08
Last modified:2024-02-07
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Crystal structures of the binary and ternary complexes of 7 alpha-hydroxysteroid dehydrogenase from Escherichia coli.
Biochemistry, 35, 1996
1E6W
DownloadVisualize
BU of 1e6w by Molmil
Rat brain 3-hydroxyacyl-CoA dehydrogenase binary complex with NADH and estradiol
Descriptor: ESTRADIOL, NICOTINAMIDE-ADENINE-DINUCLEOTIDE, SHORT CHAIN 3-HYDROXYACYL-COA DEHYDROGENASE
Authors:Read, J.A, Powell, A.J, Brady, R.L.
Deposit date:2000-08-23
Release date:2001-05-25
Last modified:2023-12-13
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Recognition of Structurally Diverse Substrates by Type II 3-Hydroxyacyl-Coa Dehydrogenase (Hadh II) Amyloid-Beta Binding Alcohol Dehydrogenase (Abad)
J.Mol.Biol., 303, 2000
1DHR
DownloadVisualize
BU of 1dhr by Molmil
CRYSTAL STRUCTURE OF RAT LIVER DIHYDROPTERIDINE REDUCTASE
Descriptor: DIHYDROPTERIDINE REDUCTASE, NICOTINAMIDE-ADENINE-DINUCLEOTIDE
Authors:Varughese, K.I, Skinner, M.M, Whiteley, J.M, Matthews, D.A, Xuong, N.H.
Deposit date:1992-03-30
Release date:1993-07-15
Last modified:2024-02-07
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Crystal structure of rat liver dihydropteridine reductase.
Proc.Natl.Acad.Sci.USA, 89, 1992
1DIR
DownloadVisualize
BU of 1dir by Molmil
CRYSTAL STRUCTURE OF A MONOCLINIC FORM OF DIHYDROPTERIDINE REDUCTASE FROM RAT LIVER
Descriptor: DIHYDROPTERIDINE REDUCTASE, NICOTINAMIDE-ADENINE-DINUCLEOTIDE
Authors:Varughese, K.I, Su, Y, Skinner, M.M, Matthews, D.A, Whitely, J.M, Xuong, N.H.
Deposit date:1994-04-18
Release date:1994-07-31
Last modified:2024-02-07
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Crystal structure of a monoclinic form of dihydropteridine reductase from rat liver.
Acta Crystallogr.,Sect.D, 50, 1994
1GEG
DownloadVisualize
BU of 1geg by Molmil
CRYATAL STRUCTURE ANALYSIS OF MESO-2,3-BUTANEDIOL DEHYDROGENASE
Descriptor: ACETOIN REDUCTASE, BETA-MERCAPTOETHANOL, MAGNESIUM ION, ...
Authors:Otagiri, M, Kurisu, G, Ui, S, Kusunoki, M.
Deposit date:2000-11-10
Release date:2001-02-28
Last modified:2023-12-27
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Crystal structure of meso-2,3-butanediol dehydrogenase in a complex with NAD+ and inhibitor mercaptoethanol at 1.7 A resolution for understanding of chiral substrate recognition mechanisms.
J.Biochem., 129, 2001
1EQU
DownloadVisualize
BU of 1equ by Molmil
TYPE 1 17-BETA HYDROXYSTEROID DEHYDROGENASE EQUILIN COMPLEXED WITH NADP+
Descriptor: EQUILIN, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, PROTEIN (ESTRADIOL 17 BETA-DEHYDROGENASE 1)
Authors:Sawicki, M.W, Erman, M, Puranen, T, Vihko, P, Ghosh, D.
Deposit date:1998-12-02
Release date:1999-12-02
Last modified:2023-08-09
Method:X-RAY DIFFRACTION (3 Å)
Cite:Structure of the ternary complex of human 17beta-hydroxysteroid dehydrogenase type 1 with 3-hydroxyestra-1,3,5,7-tetraen-17-one (equilin) and NADP+.
Proc.Natl.Acad.Sci.USA, 96, 1999
1GZ6
DownloadVisualize
BU of 1gz6 by Molmil
(3R)-HYDROXYACYL-COA DEHYDROGENASE FRAGMENT OF RAT PEROXISOMAL MULTIFUNCTIONAL ENZYME TYPE 2
Descriptor: 1,4-DIHYDRONICOTINAMIDE ADENINE DINUCLEOTIDE, ESTRADIOL 17 BETA-DEHYDROGENASE 4, SULFATE ION
Authors:Haapalainen, A.M, Hiltunen, J.K, Glumoff, T.
Deposit date:2002-05-16
Release date:2003-01-24
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.38 Å)
Cite:Binary Structure of the Two-Domain (3R)-Hydroxyacyl-Coa Dehydrogenase from Rat Peroxisomal Multifunctional Enzyme Type 2 at 2.38 A Resolution
Structure, 11, 2003
1HDR
DownloadVisualize
BU of 1hdr by Molmil
THE CRYSTALLOGRAPHIC STRUCTURE OF A HUMAN DIHYDROPTERIDINE REDUCTASE NADH BINARY COMPLEX EXPRESSED IN ESCHERICHIA COLI BY A CDNA CONSTRUCTED FROM ITS RAT HOMOLOGUE
Descriptor: DIHYDROPTERIDINE REDUCTASE, NICOTINAMIDE-ADENINE-DINUCLEOTIDE
Authors:Varughese, K.I, Su, Y, Xuong, N.H, Whiteley, J.M.
Deposit date:1993-08-18
Release date:1994-08-31
Last modified:2024-02-07
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:The crystallographic structure of a human dihydropteridine reductase NADH binary complex expressed in Escherichia coli by a cDNA constructed from its rat homologue.
J.Biol.Chem., 268, 1993
3DHE
DownloadVisualize
BU of 3dhe by Molmil
ESTROGENIC 17-BETA HYDROXYSTEROID DEHYDROGENASE COMPLEXED DEHYDROEPIANDROSTERONE
Descriptor: 3-BETA-HYDROXY-5-ANDROSTEN-17-ONE, ESTROGENIC 17-BETA HYDROXYSTEROID DEHYDROGENASE
Authors:Han, Q, Campbell, R.L, Gangloff, A, Lin, S.X.
Deposit date:1998-03-25
Release date:1999-09-25
Last modified:2023-08-09
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Dehydroepiandrosterone and dihydrotestosterone recognition by human estrogenic 17beta-hydroxysteroid dehydrogenase. C-18/c-19 steroid discrimination and enzyme-induced strain.
J.Biol.Chem., 275, 2000
3E9N
DownloadVisualize
BU of 3e9n by Molmil
Crystal structure of a putative short-chain dehydrogenase/reductase from Corynebacterium glutamicum
Descriptor: PUTATIVE SHORT-CHAIN DEHYDROGENASE/REDUCTASE
Authors:Bonanno, J.B, Gilmore, M, Bain, K.T, Hu, S, Romero, R, Smith, D, Wasserman, S, Sauder, J.M, Burley, S.K, Almo, S.C, New York SGX Research Center for Structural Genomics (NYSGXRC)
Deposit date:2008-08-22
Release date:2008-09-02
Last modified:2024-02-21
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Crystal structure of a putative short-chain dehydrogenase/reductase from Corynebacterium glutamicum
To be Published
3BZU
DownloadVisualize
BU of 3bzu by Molmil
Crystal structure of human 11-beta-hydroxysteroid dehydrogenase(HSD1) in complex with NADP and thiazolone inhibitor
Descriptor: (5S)-2-{[(1S)-1-(2-fluorophenyl)ethyl]amino}-5-methyl-5-(trifluoromethyl)-1,3-thiazol-4(5H)-one, Corticosteroid 11-beta-dehydrogenase isozyme 1, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE
Authors:Min, X, Sudom, A, Xu, H, Wang, Z, Walker, N.P.
Deposit date:2008-01-18
Release date:2008-06-10
Last modified:2024-02-21
Method:X-RAY DIFFRACTION (2.25 Å)
Cite:Structural characterization and pharmacodynamic effects of an orally active 11beta-hydroxysteroid dehydrogenase type 1 inhibitor.
Chem.Biol.Drug Des., 71, 2008
3CSD
DownloadVisualize
BU of 3csd by Molmil
Actinorhodin Polyketide Ketoreductase Mutant P94L bound to NADPH and the Inhibitor Emodin
Descriptor: 3-METHYL-1,6,8-TRIHYDROXYANTHRAQUINONE, NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, Putative ketoacyl reductase
Authors:Javidpour, P.
Deposit date:2008-04-09
Release date:2009-04-14
Last modified:2024-02-21
Method:X-RAY DIFFRACTION (2.29 Å)
Cite:Actinorhodin Polyketide Ketoreductase Mutant P94L bound to NADPH and the Inhibitor Emodin
To be Published
3D5Q
DownloadVisualize
BU of 3d5q by Molmil
Crystal Structure of 11b-HSD1 in Complex with Triazole Inhibitor
Descriptor: 3-[1-(4-fluorophenyl)cyclopropyl]-4-(1-methylethyl)-5-[4-(trifluoromethoxy)phenyl]-4H-1,2,4-triazole, Corticosteroid 11-beta-dehydrogenase isozyme 1, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE
Authors:Wang, Z, Liu, J, Sudom, A, Walker, N.P.C.
Deposit date:2008-05-16
Release date:2008-10-07
Last modified:2024-02-21
Method:X-RAY DIFFRACTION (2.55 Å)
Cite:Distinctive molecular inhibition mechanisms for selective inhibitors of human 11beta-hydroxysteroid dehydrogenase type 1.
Bioorg.Med.Chem., 16, 2008
3DEY
DownloadVisualize
BU of 3dey by Molmil
Crystal structure of 17beta-HSD1 with DHT in normal and reverse orientation.
Descriptor: 5-ALPHA-DIHYDROTESTOSTERONE, Estradiol 17-beta-dehydrogenase 1, GLYCEROL
Authors:Mazumdar, M.
Deposit date:2008-06-10
Release date:2009-09-29
Last modified:2024-02-21
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:17beta-HSD1 stimulates breast cancer by DHT inactivation in addition to estradiol production.
To be Published
3EY4
DownloadVisualize
BU of 3ey4 by Molmil
Further studies with the 2-amino-1,3-thiazol-4(5H)-one class of 11-hydroxysteroid dehydrogenase type 1 (11-HSD1) inhibitors: Reducing pregnane X receptor (PXR) activity and exploring activity in a monkey pharmacodynamic model
Descriptor: (5S)-2-{[(1S)-1-(4-fluorophenyl)ethyl]amino}-5-(1-hydroxy-1-methylethyl)-5-methyl-1,3-thiazol-4(5H)-one, 11-beta-Hydroxysteroid Dehydrogenase 1, NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE
Authors:Zhang, J.D, Jordan, S.R, Li, V.
Deposit date:2008-10-17
Release date:2008-11-11
Last modified:2023-12-27
Method:X-RAY DIFFRACTION (3 Å)
Cite:Further studies with the 2-amino-1,3-thiazol-4(5H)-one class of 11-hydroxysteroid dehydrogenase type 1 (11-HSD1) inhibitors: Reducing pregnane X receptor (PXR) activity and exploring activity in a monkey pharmacodynamic model
To be Published, 2008
3EZL
DownloadVisualize
BU of 3ezl by Molmil
Crystal Structure of Acetoacetyl-CoA Reductase from Burkholderia Pseudomallei 1710b
Descriptor: Acetoacetyl-CoA reductase, O-ACETALDEHYDYL-HEXAETHYLENE GLYCOL
Authors:Seattle Structural Genomics Center for Infectious Disease (SSGCID)
Deposit date:2008-10-23
Release date:2009-07-07
Last modified:2023-09-06
Method:X-RAY DIFFRACTION (2.25 Å)
Cite:Crystal Structure of Acetoacetyl-CoA Reductase from Burkholderia Pseudomallei 1710b
To be Published
3F1L
DownloadVisualize
BU of 3f1l by Molmil
The 0.95 A structure of an oxidoreductase, yciK from E.coli
Descriptor: Uncharacterized oxidoreductase yciK
Authors:Vijayalakshmi, J, Woodard, R.W.
Deposit date:2008-10-28
Release date:2008-11-18
Last modified:2023-09-06
Method:X-RAY DIFFRACTION (0.95 Å)
Cite:Structure of an oxidoreductase, yciK from E. coli, in two crystal forms - NADP+ unbound structure at 0.95 A resolution
to be published
3D4N
DownloadVisualize
BU of 3d4n by Molmil
Crystal Structure of Human 11-beta-Hydroxysteroid Dehydrogenase (HSD1) in Complex with Sulfonamide Inhibitor
Descriptor: 1-{[(3R)-3-methyl-4-({4-[(1S)-2,2,2-trifluoro-1-hydroxy-1-methylethyl]phenyl}sulfonyl)piperazin-1-yl]methyl}cyclopropanecarboxamide, Corticosteroid 11-beta-dehydrogenase isozyme 1, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE
Authors:Wang, Z, Liu, J, Sudom, A, Walker, N.P.
Deposit date:2008-05-14
Release date:2008-07-22
Last modified:2024-02-21
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Discovery of Novel, Potent Benzamide Inhibitors of 11beta-Hydroxysteroid Dehydrogenase Type 1 (11beta-HSD1) Exhibiting Oral Activity in an Enzyme Inhibition ex Vivo Model
J.Med.Chem., 51, 2008
3D3E
DownloadVisualize
BU of 3d3e by Molmil
Crystal Structure of Human 11-beta-Hydroxysteroid Dehydrogenase (HSD1) in Complex with Benzamide Inhibitor
Descriptor: Corticosteroid 11-beta-dehydrogenase isozyme 1, N-cyclopropyl-N-(trans-4-pyridin-3-ylcyclohexyl)-4-[(1S)-2,2,2-trifluoro-1-hydroxy-1-methylethyl]benzamide, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE
Authors:Wang, Z, Sudom, A, Liu, J, Walker, N.P.
Deposit date:2008-05-09
Release date:2008-07-01
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Discovery of Novel, Potent Benzamide Inhibitors of 11beta-Hydroxysteroid Dehydrogenase Type 1 (11beta-HSD1) Exhibiting Oral Activity in an Enzyme Inhibition ex Vivo Model
J.Med.Chem., 51, 2008
3CH6
DownloadVisualize
BU of 3ch6 by Molmil
Crystal Structure of 11beta-HSD1 Double Mutant (L262R, F278E) Complexed with (3,3-dimethylpiperidin-1-yl)(6-(3-fluoro-4-methylphenyl)pyridin-2-yl)methanone
Descriptor: (3,3-dimethylpiperidin-1-yl)(6-(3-fluoro-4-methylphenyl)pyridin-2-yl)methanone, Corticosteroid 11-beta-dehydrogenase isozyme 1, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE
Authors:Sheriff, S.
Deposit date:2008-03-07
Release date:2008-06-10
Last modified:2024-04-03
Method:X-RAY DIFFRACTION (2.35 Å)
Cite:Pyridine amides as potent and selective inhibitors of 11beta-hydroxysteroid dehydrogenase type 1
Bioorg.Med.Chem.Lett., 18, 2008
3CZR
DownloadVisualize
BU of 3czr by Molmil
Crystal Structure of Human 11-beta-Hydroxysteroid Dehydrogenase (HSD1) in Complex with Arylsulfonylpiperazine Inhibitor
Descriptor: (2R)-1-[(4-tert-butylphenyl)sulfonyl]-2-methyl-4-(4-nitrophenyl)piperazine, 3-[(3-CHOLAMIDOPROPYL)DIMETHYLAMMONIO]-1-PROPANESULFONATE, Corticosteroid 11-beta-dehydrogenase isozyme 1, ...
Authors:Wang, Z, Sudom, A, Walker, N.P.
Deposit date:2008-04-29
Release date:2008-06-17
Last modified:2024-02-21
Method:X-RAY DIFFRACTION (2.35 Å)
Cite:Discovery and Initial SAR of Arylsulfonylpiperazine Inhibitors of 11beta-Hydroxysteroid Dehydrogenase Type 1 (11beta-HSD1)
Bioorg.Med.Chem.Lett., 18, 2008
3E03
DownloadVisualize
BU of 3e03 by Molmil
Crystal structure of a putative dehydrogenase from Xanthomonas campestris
Descriptor: CALCIUM ION, Short chain dehydrogenase
Authors:Sampathkumar, P, Wasserman, S, Rutter, M, Hu, S, Bain, K, Rodgers, L, Atwell, S, Sauder, J.M, Burley, S.K, New York SGX Research Center for Structural Genomics (NYSGXRC)
Deposit date:2008-07-30
Release date:2008-09-16
Last modified:2021-02-10
Method:X-RAY DIFFRACTION (1.69 Å)
Cite:Crystal structure of a putative dehydrogenase from Xanthomonas campestris
To be Published
3DWF
DownloadVisualize
BU of 3dwf by Molmil
Crystal Structure of the Guinea Pig 11beta-Hydroxysteroid Dehydrogenase Type 1 Mutant F278E
Descriptor: 11-beta-hydroxysteroid dehydrogenase 1, GLYCEROL, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, ...
Authors:Lawson, A.J, Ride, J.P, White, S.A, Walker, E.A.
Deposit date:2008-07-22
Release date:2009-08-11
Last modified:2024-02-21
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Mutations of key hydrophobic surface residues of 11 beta-hydroxysteroid dehydrogenase type 1 increase solubility and monodispersity in a bacterial expression system
Protein Sci., 18, 2009
3F1K
DownloadVisualize
BU of 3f1k by Molmil
Crystal Structure of yciK from E. coli, an oxidoreductase, complexed with NADP+ at 2.6A resolution
Descriptor: NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, Uncharacterized oxidoreductase yciK
Authors:Vijayalakshmi, J, Woodard, R.W.
Deposit date:2008-10-28
Release date:2008-11-18
Last modified:2023-12-27
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Structure of an oxidoreductase, yciK from E. coli, in two crystal forms - NADP+ unbound structure at 0.95 A resolution
to be published

225158

PDB entries from 2024-09-18

PDB statisticsPDBj update infoContact PDBjnumon