3D3E
Crystal Structure of Human 11-beta-Hydroxysteroid Dehydrogenase (HSD1) in Complex with Benzamide Inhibitor
Summary for 3D3E
Entry DOI | 10.2210/pdb3d3e/pdb |
Related | 3CZR |
Descriptor | Corticosteroid 11-beta-dehydrogenase isozyme 1, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, N-cyclopropyl-N-(trans-4-pyridin-3-ylcyclohexyl)-4-[(1S)-2,2,2-trifluoro-1-hydroxy-1-methylethyl]benzamide, ... (4 entities in total) |
Functional Keywords | oxidoreductase, 11beta, hydroxysteroid, dehydrogenase, endoplasmic reticulum, glycoprotein, lipid metabolism, membrane, microsome, nadp, polymorphism, signal-anchor, steroid metabolism, transmembrane |
Biological source | Homo sapiens (Human) |
Cellular location | Endoplasmic reticulum membrane; Single-pass type II membrane protein: P28845 |
Total number of polymer chains | 4 |
Total formula weight | 132051.04 |
Authors | Wang, Z.,Sudom, A.,Liu, J.,Walker, N.P. (deposition date: 2008-05-09, release date: 2008-07-01, Last modification date: 2023-08-30) |
Primary citation | Julian, L.D.,Wang, Z.,Bostick, T.,Caille, S.,Choi, R.,Degraffenreid, M.,Di, Y.,He, X.,Hungate, R.W.,Jaen, J.C.,Liu, J.,Monshouwer, M.,McMinn, D.,Rew, Y.,Sudom, A.,Sun, D.,Tu, H.,Ursu, S.,Walker, N.,Yan, X.,Ye, Q.,Powers, J.P. Discovery of Novel, Potent Benzamide Inhibitors of 11beta-Hydroxysteroid Dehydrogenase Type 1 (11beta-HSD1) Exhibiting Oral Activity in an Enzyme Inhibition ex Vivo Model J.Med.Chem., 51:3953-3960, 2008 Cited by PubMed: 18553955DOI: 10.1021/jm800310g PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.6 Å) |
Structure validation
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