3CZR

Crystal Structure of Human 11-beta-Hydroxysteroid Dehydrogenase (HSD1) in Complex with Arylsulfonylpiperazine Inhibitor

Summary for 3CZR

• Entry DOI: 10.2210/pdb3czr/pdb
• Descriptor: Corticosteroid 11-beta-dehydrogenase isozyme 1, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, (2R)-1-[(4-tert-butylphenyl)sulfonyl]-2-methyl-4-(4-nitrophenyl)piperazine, ... (5 entities in total)
• Functional Keywords: oxidoreductase, 11beta, hydroxysteroid, dehydrogenase, endoplasmic reticulum, glycoprotein, lipid metabolism, membrane, microsome, nadp, polymorphism, signal-anchor, steroid metabolism, transmembrane
• Biological source: Homo sapiens (Human)
• Cellular location: Endoplasmic reticulum membrane; Single-pass type II membrane protein: P28845
• Total number of polymer chains: 2
• Total formula weight: 66192.96

Authors

Wang, Z.,Sudom, A.,Walker, N.P. (deposition date: 2008-04-29, release date: 2008-06-17, Last modification date: 2024-02-21)

• Primary citation: Sun, D.,Wang, Z.,Di, Y.,Jaen, J.C.,Labelle, M.,Ma, J.,Miao, S.,Sudom, A.,Tang, L.,Tomooka, C.S.,Tu, H.,Ursu, S.,Walker, N.,Yan, X.,Ye, Q.,Powers, J.P.; Discovery and Initial SAR of Arylsulfonylpiperazine Inhibitors of 11beta-Hydroxysteroid Dehydrogenase Type 1 (11beta-HSD1); Bioorg.Med.Chem.Lett., 18:3513-3516, 2008; PubMed: 18511278; DOI: 10.1016/j.bmcl.2008.05.025

Experimental method

X-RAY DIFFRACTION (2.35 Å)