3BZU
Crystal structure of human 11-beta-hydroxysteroid dehydrogenase(HSD1) in complex with NADP and thiazolone inhibitor
Summary for 3BZU
Entry DOI | 10.2210/pdb3bzu/pdb |
Related | 1xu9 |
Descriptor | Corticosteroid 11-beta-dehydrogenase isozyme 1, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, (5S)-2-{[(1S)-1-(2-fluorophenyl)ethyl]amino}-5-methyl-5-(trifluoromethyl)-1,3-thiazol-4(5H)-one, ... (4 entities in total) |
Functional Keywords | 11beta hydroxysteroid dehydrogenase, endoplasmic reticulum, glycoprotein, lipid metabolism, membrane, microsome, nadp, oxidoreductase, signal-anchor, steroid metabolism, transmembrane |
Biological source | Homo sapiens (human) |
Cellular location | Endoplasmic reticulum membrane; Single-pass type II membrane protein: P28845 |
Total number of polymer chains | 4 |
Total formula weight | 131602.34 |
Authors | Min, X.,Sudom, A.,Xu, H.,Wang, Z.,Walker, N.P. (deposition date: 2008-01-18, release date: 2008-06-10, Last modification date: 2024-02-21) |
Primary citation | Hale, C.,Veniant, M.,Wang, Z.,Chen, M.,McCormick, J.,Cupples, R.,Hickman, D.,Min, X.,Sudom, A.,Xu, H.,Matsumoto, G.,Fotsch, C.,St Jean, D.J.,Wang, M. Structural characterization and pharmacodynamic effects of an orally active 11beta-hydroxysteroid dehydrogenase type 1 inhibitor. Chem.Biol.Drug Des., 71:36-44, 2008 Cited by PubMed: 18069989DOI: 10.1111/j.1747-0285.2007.00603.x PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.25 Å) |
Structure validation
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