1XU9

Crystal Structure of the Interface Closed Conformation of 11b-hydroxysteroid dehydrogenase isozyme 1

Summary for 1XU9

• Entry DOI: 10.2210/pdb1xu9/pdb
• Related: 1XU7
• Descriptor: Corticosteroid 11-beta-dehydrogenase, isozyme 1, NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, 3-[(3-CHOLAMIDOPROPYL)DIMETHYLAMMONIO]-1-PROPANESULFONATE, ... (5 entities in total)
• Functional Keywords: 11beta, hydroxysteroid, dehydrogenase, sdr, oxidoreductase
• Biological source: Homo sapiens (human)
• Cellular location: Endoplasmic reticulum membrane; Single-pass type II membrane protein: P28845
• Total number of polymer chains: 4
• Total formula weight: 132983.93

Authors

Hosfield, D.J.,Wu, Y.,Skene, R.J.,Hilger, M.,Jennings, A.,Snell, G.P.,Aertgeerts, K. (deposition date: 2004-10-25, release date: 2004-11-02, Last modification date: 2024-02-14)

• Primary citation: Hosfield, D.J.,Wu, Y.,Skene, R.J.,Hilger, M.,Jennings, A.,Snell, G.P.,Aertgeerts, K.; Conformational Flexibility in Crystal Structures of Human 11beta-hydroxysteroid dehydrogenase type I provide insights into glucocorticoid interconversion and enzyme regulation.; J.Biol.Chem., 280:4639-4648, 2005; PubMed: 15513927; DOI: 10.1074/jbc.M411104200

Experimental method

X-RAY DIFFRACTION (1.55 Å)