3CH6

Crystal Structure of 11beta-HSD1 Double Mutant (L262R, F278E) Complexed with (3,3-dimethylpiperidin-1-yl)(6-(3-fluoro-4-methylphenyl)pyridin-2-yl)methanone

Summary for 3CH6

• Entry DOI: 10.2210/pdb3ch6/pdb
• Descriptor: Corticosteroid 11-beta-dehydrogenase isozyme 1, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, (3,3-dimethylpiperidin-1-yl)(6-(3-fluoro-4-methylphenyl)pyridin-2-yl)methanone, ... (4 entities in total)
• Functional Keywords: 11b-hsd1, sdr, dehydrogenase, hydroxysteroid, inhibitor, oxidoreductase
• Biological source: Homo sapiens (human)
• Cellular location: Endoplasmic reticulum membrane ; Single-pass type II membrane protein : P28845
• Total number of polymer chains: 4
• Total formula weight: 129664.64

Authors

Sheriff, S. (deposition date: 2008-03-07, release date: 2008-06-10, Last modification date: 2024-04-03)

• Primary citation: Wang, H.,Ruan, Z.,Li, J.J.,Simpkins, L.M.,Smirk, R.A.,Wu, S.C.,Hutchins, R.D.,Nirschl, D.S.,Van Kirk, K.,Cooper, C.B.,Sutton, J.C.,Ma, Z.,Golla, R.,Seethala, R.,Salyan, M.E.,Nayeem, A.,Krystek, S.R.,Sheriff, S.,Camac, D.M.,Morin, P.E.,Carpenter, B.,Robl, J.A.,Zahler, R.,Gordon, D.A.,Hamann, L.G.; Pyridine amides as potent and selective inhibitors of 11beta-hydroxysteroid dehydrogenase type 1; Bioorg.Med.Chem.Lett., 18:3168-3172, 2008; PubMed: 18485702; DOI: 10.1016/j.bmcl.2008.04.069

Experimental method

X-RAY DIFFRACTION (2.35 Å)