PDB: 289 件ウェブページステータス検索Chemie searchBIRD

---

8TPW	Crosslinked 6-deoxyerythronolide B synthase (DEBS) Module 3 in complex with antibody fragment 1B2: cis-oriented 1B2 and ACP 分子名称: Antibody Fragment 1B2, Heavy Chain, Light Chain, ... 著者 Cogan, D.P, Soohoo, A.M, Chen, M, Brodsky, K.L, Liu, Y, Khosla, C. 登録日 2023-08-05 公開日 2024-08-07 最終更新日 2024-09-04 実験手法 ELECTRON MICROSCOPY (3.46 Å) 主引用文献 Structural basis for intermodular communication in assembly-line polyketide biosynthesis. Nat.Chem.Biol., 2024
8TPX	Crosslinked 6-deoxyerythronolide B synthase (DEBS) Module 3 in complex with antibody fragment 1B2: trans-oriented 1B2 and ACP 分子名称: Antibody Fragment 1B2, Heavy Chain, Light Chain, ... 著者 Cogan, D.P, Soohoo, A.M, Chen, M, Brodsky, K.L, Liu, Y, Khosla, C. 登録日 2023-08-05 公開日 2024-08-07 最終更新日 2024-09-04 実験手法 ELECTRON MICROSCOPY (3.4 Å) 主引用文献 Structural basis for intermodular communication in assembly-line polyketide biosynthesis. Nat.Chem.Biol., 2024
8TKO	KS-AT core of 6-deoxyerythronolide B synthase (DEBS) Module 3 crosslinked with its translocation ACP partner of Module 2 分子名称: EryAI, EryAII 著者 Cogan, D.P, Soohoo, A.M, Chen, M, Brodsky, K.L, Liu, Y, Khosla, C. 登録日 2023-07-25 公開日 2024-07-31 最終更新日 2024-09-04 実験手法 ELECTRON MICROSCOPY (3.05 Å) 主引用文献 Structural basis for intermodular communication in assembly-line polyketide biosynthesis. Nat.Chem.Biol., 2024
8TJP	KS-AT core of 6-deoxyerythronolide B synthase (DEBS) Module 3 crosslinked with its elongation ACP partner 分子名称: EryAII 著者 Cogan, D.P, Soohoo, A.M, Chen, M, Brodsky, K.L, Liu, Y, Khosla, C. 登録日 2023-07-23 公開日 2024-07-24 最終更新日 2024-09-04 実験手法 ELECTRON MICROSCOPY (3.71 Å) 主引用文献 Structural basis for intermodular communication in assembly-line polyketide biosynthesis. Nat.Chem.Biol., 2024
8TJN	Crosslinked 6-deoxyerythronolide B synthase (DEBS) Module 1 in complex with antibody fragment 1B2: Crosslinked State 1 分子名称: Antibody Fragment 1B2, Heavy Chain, Light Chain, ... 著者 Cogan, D.P, Soohoo, A.M, Chen, M, Brodsky, K.L, Liu, Y, Khosla, C. 登録日 2023-07-23 公開日 2024-07-24 最終更新日 2024-09-04 実験手法 ELECTRON MICROSCOPY (3.73 Å) 主引用文献 Structural basis for intermodular communication in assembly-line polyketide biosynthesis. Nat.Chem.Biol., 2024
9F48	KS + AT di-domain of polyketide synthase 13 in Mycobacterium tuberculosis 分子名称: Polyketide synthase Pks13 著者 Johnston, H.E, Futterer, K. 登録日 2024-04-26 公開日 2024-05-22 実験手法 ELECTRON MICROSCOPY (3.4 Å) 主引用文献 CryoEM structure of the di-domain core of Mycobacterium tuberculosis polyketide synthase 13, essential for mycobacterial mycolic acid synthesis To be published
8OII	Cryo-EM KSB domain of RhiE from Burkholderia rhizoxinica 分子名称: RhiE protein,Polyketide synthase domain protein RhiE 著者 Capper, M.J, Koehnke, J. 登録日 2023-03-22 公開日 2024-04-03 実験手法 ELECTRON MICROSCOPY (2.84 Å) 主引用文献 Structural Analysis of a Chain-Branching Polyketide Synthase Module To Be Published
8R0I	Pseudomonas aeruginosa FabF C164A in complex with 3-amino-N-(1,5-dimethyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazol-4-yl)benzamide 分子名称: 1,2-ETHANEDIOL, 3-azanyl-N-(1,5-dimethyl-3-oxidanylidene-2-phenyl-pyrazol-4-yl)benzamide, 3-oxoacyl-[acyl-carrier-protein] synthase 2, ... 著者 Yadrykhinsky, V, Brenk, R. 登録日 2023-10-31 公開日 2024-03-06 最終更新日 2024-05-08 実験手法 X-RAY DIFFRACTION (1.51 Å) 主引用文献 Design, quality and validation of the EU-OPENSCREEN fragment library poised to a high-throughput screening collection. Rsc Med Chem, 15, 2024
8R1V	Pseudomonas aeruginosa FabF C164A in complex with N-(1,5-dimethyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazol-4-yl)-2-(4-methoxyphenoxy)acetamide 分子名称: 3-oxoacyl-[acyl-carrier-protein] synthase 2, DIMETHYL SULFOXIDE, FORMIC ACID, ... 著者 Yadrykhinsky, V, Brenk, R. 登録日 2023-11-02 公開日 2024-03-06 最終更新日 2024-05-08 実験手法 X-RAY DIFFRACTION (2.087 Å) 主引用文献 Design, quality and validation of the EU-OPENSCREEN fragment library poised to a high-throughput screening collection. Rsc Med Chem, 15, 2024
8CG5	The ACP crosslinked to the KS of the cercosporin fungal non-reducing polyketide synthase (NR-PKS) CTB1 (SAT-KS:ACP-MAT) 分子名称: Acyl carrier protein (ACP) of Non-reducing polyketide synthase CTB1, Non-reducing polyketide synthase CTB1, N~3~-[(2R)-2-hydroxy-3,3-dimethyl-4-(phosphonooxy)butanoyl]-N-[2-(propanoylamino)ethyl]-beta-alaninamide 著者 Munoz-Hernandez, H, Tittes, Y.U, Maier, T. 登録日 2023-02-03 公開日 2024-02-21 実験手法 ELECTRON MICROSCOPY (2.7 Å) 主引用文献 CryoEM structure of ACP crosslinked to KS of the cercosporin fungal non-reducing polyketide synthase (NR-PKS) CTB1 (SAT-KS:ACP-MAT) at 2.7 Angstroms resolution To Be Published
8CG4	The organise full-length structure of the fungal non-reducing polyketide synthase (NR-PKS) PksA 分子名称: Norsolorinic acid synthase 著者 Munoz-Hernandez, H, Maier, T. 登録日 2023-02-03 公開日 2024-02-21 実験手法 ELECTRON MICROSCOPY (2.6 Å) 主引用文献 CryoEM structure of the Aspergilus sp. fungal non-reducing polyketide synthase (NR-PKS) PksA at 2.6 Angstroms resolution To Be Published
8CG6	The ACP crosslinked to the SAT of the cercosporin fungal non-reducing polyketide synthase (NR-PKS) CTB1 (ACP:SAT-KS-MAT) 分子名称: Acyl carrier protein (ACP) of Non-reducing polyketide synthase CTB1, Non-reducing polyketide synthase CTB1, N~3~-[(2R)-2-hydroxy-3,3-dimethyl-4-(phosphonooxy)butanoyl]-N-[2-(propanoylamino)ethyl]-beta-alaninamide 著者 Munoz-Hernandez, H, Tittes, Y.U, Maier, T. 登録日 2023-02-03 公開日 2024-02-21 実験手法 ELECTRON MICROSCOPY (3.4 Å) 主引用文献 CryoEM structure of ACP crosslinked to SAT of the cercosporin fungal non-reducing polyketide synthase (NR-PKS) CTB1 (ACP:SAT-KS-MAT) at 3.4 Angstroms resolution To Be Published
8PJ0	Pseudomonas aeruginosa FabF C164A mutant in complex with N-(1,5-dimethyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazol-4-yl)-3-methylbutanamide 分子名称: 3-oxoacyl-[acyl-carrier-protein] synthase 2, DIMETHYL SULFOXIDE, FORMIC ACID, ... 著者 Georgiou, C, Brenk, R, Espeland, L.O. 登録日 2023-06-22 公開日 2024-02-21 最終更新日 2024-05-08 実験手法 X-RAY DIFFRACTION (1.7 Å) 主引用文献 Design, quality and validation of the EU-OPENSCREEN fragment library poised to a high-throughput screening collection. Rsc Med Chem, 15, 2024
8BY8	The cercosporin fungal non-reducing polyketide synthase (NR-PKS) CTB1 (SAT-KS-MAT) 分子名称: Non-reducing polyketide synthase CTB1 著者 Munoz-Hernandez, H, Maier, T. 登録日 2022-12-12 公開日 2024-01-10 実験手法 ELECTRON MICROSCOPY (2.5 Å) 主引用文献 The cercosporin fungal non-reducing polyketide synthase (NR-PKS) CTB1 (SAT-KS-MAT) at 2.5 Angstroms resolution To Be Published
8CN7	Pa.FabF-C164Q in complex with platencin 分子名称: 2,4-dihydroxy-3-({3-[(2S,4aS,8S,8aR)-8-methyl-3-methylidene-7-oxo-1,3,4,7,8,8a-hexahydro-2H-2,4a-ethanonaphthalen-8-yl]propanoyl}amino)benzoic acid, 3-oxoacyl-[acyl-carrier-protein] synthase 2, DIMETHYL SULFOXIDE 著者 Georgiou, C, Brenk, R. 登録日 2023-02-22 公開日 2024-01-10 実験手法 X-RAY DIFFRACTION (2.1 Å) 主引用文献 New starting points for antibiotics targeting P. aeruginosa FabF discovered by crystallographic fragment screening followed by hit expansion Chemrxiv, 2023
8COU	Pa.FabF-C164Q in complex with 3-acetamido-4-methoxybenzoic acid 分子名称: 3-acetamido-4-methoxy-benzoic acid, 3-oxoacyl-[acyl-carrier-protein] synthase 2, DIMETHYL SULFOXIDE, ... 著者 Georgiou, C, Brenk, R. 登録日 2023-02-28 公開日 2024-01-10 実験手法 X-RAY DIFFRACTION (1.68 Å) 主引用文献 New starting points for antibiotics targeting P. aeruginosa FabF discovered by crystallographic fragment screening followed by hit expansion Chemrxiv, 2023
8CN5	Pa.FabF-C164Q in complex with propan-2-yl 1~{H}-pyrazole-3-carboxylate 分子名称: 3-oxoacyl-[acyl-carrier-protein] synthase 2, DIMETHYL SULFOXIDE, PHOSPHATE ION, ... 著者 Georgiou, C, Brenk, R. 登録日 2023-02-22 公開日 2024-01-10 実験手法 X-RAY DIFFRACTION (1.93 Å) 主引用文献 New starting points for antibiotics targeting P. aeruginosa FabF discovered by crystallographic fragment screening followed by hit expansion Chemrxiv, 2023
8COV	Pa.FabF-C164Q in complex with 6-chloro-2-methyl-1H-indole-5-carboxylic acid 分子名称: 3-oxoacyl-[acyl-carrier-protein] synthase 2, 6-chloranyl-2-methyl-1~{H}-indole-5-carboxylic acid, DIMETHYL SULFOXIDE, ... 著者 Georgiou, C, Brenk, R, Espeland, L.O. 登録日 2023-02-28 公開日 2024-01-10 実験手法 X-RAY DIFFRACTION (1.8 Å) 主引用文献 New starting points for antibiotics targeting P. aeruginosa FabF discovered by crystallographic fragment screening followed by hit expansion Chemrxiv, 2023
8CN4	Pa.FabF-C164Q in complex with 5-acetamido-2-chlorobenzoic acid 分子名称: 3-oxoacyl-[acyl-carrier-protein] synthase 2, 5-acetamido-2-chloranyl-benzoic acid, DIMETHYL SULFOXIDE, ... 著者 Georgiou, C, Brenk, R. 登録日 2023-02-21 公開日 2024-01-10 実験手法 X-RAY DIFFRACTION (1.67 Å) 主引用文献 New starting points for antibiotics targeting P. aeruginosa FabF discovered by crystallographic fragment screening followed by hit expansion Chemrxiv, 2023
8CN8	apo Pseudomonas aeruginosa FabF C164A mutant 分子名称: 3-oxoacyl-[acyl-carrier-protein] synthase 2 著者 Georgiou, C, Brenk, R, Espeland, L.O. 登録日 2023-02-22 公開日 2024-01-10 実験手法 X-RAY DIFFRACTION (1.8 Å) 主引用文献 New starting points for antibiotics targeting P. aeruginosa FabF discovered by crystallographic fragment screening followed by hit expansion Chemrxiv, 2023
8CNE	Pa.FabF-C164A in complex with N-(propan-2-yl)-1H-pyrazole-3-carboxamide 分子名称: 3-oxoacyl-[acyl-carrier-protein] synthase 2, DIMETHYL SULFOXIDE, FORMIC ACID, ... 著者 Georgiou, C, Brenk, R, Espeland, L.O. 登録日 2023-02-22 公開日 2024-01-10 実験手法 X-RAY DIFFRACTION (1.57 Å) 主引用文献 New starting points for antibiotics targeting P. aeruginosa FabF discovered by crystallographic fragment screening followed by hit expansion Chemrxiv, 2023
8CNG	Pa.FabF-C164Q in complex with ~{N}-cyclopentyl-3-methyl-1~{H}-pyrazole-5-carboxamide 分子名称: 3-oxoacyl-[acyl-carrier-protein] synthase 2, DIMETHYL SULFOXIDE, MAGNESIUM ION, ... 著者 Georgiou, C, Brenk, R. 登録日 2023-02-22 公開日 2024-01-10 実験手法 X-RAY DIFFRACTION (2.1 Å) 主引用文献 New starting points for antibiotics targeting P. aeruginosa FabF discovered by crystallographic fragment screening followed by hit expansion Chemrxiv, 2023
8CN2	Pa.FabF-C164Q in complex with N-isobutyl-1H-pyrazole-3-carboxamide 分子名称: 3-oxoacyl-[acyl-carrier-protein] synthase 2, DIMETHYL SULFOXIDE, ~{N}-(2-methylpropyl)-1~{H}-pyrazole-3-carboxamide 著者 Georgiou, C, Brenk, R. 登録日 2023-02-21 公開日 2024-01-10 実験手法 X-RAY DIFFRACTION (1.88 Å) 主引用文献 New starting points for antibiotics targeting P. aeruginosa FabF discovered by crystallographic fragment screening followed by hit expansion Chemrxiv, 2023
8PFZ	Pseudomonas aeruginosa FabF C164A mutant in complex with(S)-2-(1H-pyrazole-3-carboxamido)butanoic acid 分子名称: (2~{S})-2-(1~{H}-pyrazol-3-ylcarbonylamino)butanoic acid, 3-oxoacyl-[acyl-carrier-protein] synthase 2, CHLORIDE ION, ... 著者 Georgiou, C, Brenk, R, Yadrykhinsky, V, Espeland, L.O. 登録日 2023-06-17 公開日 2024-01-10 実験手法 X-RAY DIFFRACTION (1.78 Å) 主引用文献 New starting points for antibiotics targeting P. aeruginosa FabF discovered by crystallographic fragment screening followed by hit expansion Chemrxiv, 2023
8PD1	Pseudomonas aeruginosa FabF C164A mutant in complex with N-isopropyl-1H-imidazole-4-carboxamide 分子名称: 3-oxoacyl-[acyl-carrier-protein] synthase 2, CHLORIDE ION, DIMETHYL SULFOXIDE, ... 著者 Georgiou, C, Brenk, R, Yadrykhinsky, V, Espeland, L.O. 登録日 2023-06-11 公開日 2024-01-10 実験手法 X-RAY DIFFRACTION (1.87 Å) 主引用文献 New starting points for antibiotics targeting P. aeruginosa FabF discovered by crystallographic fragment screening followed by hit expansion Chemrxiv, 2023

 

123456789101112>