Loading
PDBj
メニューPDBj@FacebookPDBj@TwitterPDBj@YouTubewwPDB FoundationwwPDB
RCSB PDBPDBeBMRBAdv. SearchSearch help

8TPW
DownloadVisualize
BU of 8tpw by Molmil
Crosslinked 6-deoxyerythronolide B synthase (DEBS) Module 3 in complex with antibody fragment 1B2: cis-oriented 1B2 and ACP
分子名称: Antibody Fragment 1B2, Heavy Chain, Light Chain, ...
著者Cogan, D.P, Soohoo, A.M, Chen, M, Brodsky, K.L, Liu, Y, Khosla, C.
登録日2023-08-05
公開日2024-08-07
最終更新日2024-09-04
実験手法ELECTRON MICROSCOPY (3.46 Å)
主引用文献Structural basis for intermodular communication in assembly-line polyketide biosynthesis.
Nat.Chem.Biol., 2024
8TPX
DownloadVisualize
BU of 8tpx by Molmil
Crosslinked 6-deoxyerythronolide B synthase (DEBS) Module 3 in complex with antibody fragment 1B2: trans-oriented 1B2 and ACP
分子名称: Antibody Fragment 1B2, Heavy Chain, Light Chain, ...
著者Cogan, D.P, Soohoo, A.M, Chen, M, Brodsky, K.L, Liu, Y, Khosla, C.
登録日2023-08-05
公開日2024-08-07
最終更新日2024-09-04
実験手法ELECTRON MICROSCOPY (3.4 Å)
主引用文献Structural basis for intermodular communication in assembly-line polyketide biosynthesis.
Nat.Chem.Biol., 2024
8TKO
DownloadVisualize
BU of 8tko by Molmil
KS-AT core of 6-deoxyerythronolide B synthase (DEBS) Module 3 crosslinked with its translocation ACP partner of Module 2
分子名称: EryAI, EryAII
著者Cogan, D.P, Soohoo, A.M, Chen, M, Brodsky, K.L, Liu, Y, Khosla, C.
登録日2023-07-25
公開日2024-07-31
最終更新日2024-09-04
実験手法ELECTRON MICROSCOPY (3.05 Å)
主引用文献Structural basis for intermodular communication in assembly-line polyketide biosynthesis.
Nat.Chem.Biol., 2024
8TJP
DownloadVisualize
BU of 8tjp by Molmil
KS-AT core of 6-deoxyerythronolide B synthase (DEBS) Module 3 crosslinked with its elongation ACP partner
分子名称: EryAII
著者Cogan, D.P, Soohoo, A.M, Chen, M, Brodsky, K.L, Liu, Y, Khosla, C.
登録日2023-07-23
公開日2024-07-24
最終更新日2024-09-04
実験手法ELECTRON MICROSCOPY (3.71 Å)
主引用文献Structural basis for intermodular communication in assembly-line polyketide biosynthesis.
Nat.Chem.Biol., 2024
8TJN
DownloadVisualize
BU of 8tjn by Molmil
Crosslinked 6-deoxyerythronolide B synthase (DEBS) Module 1 in complex with antibody fragment 1B2: Crosslinked State 1
分子名称: Antibody Fragment 1B2, Heavy Chain, Light Chain, ...
著者Cogan, D.P, Soohoo, A.M, Chen, M, Brodsky, K.L, Liu, Y, Khosla, C.
登録日2023-07-23
公開日2024-07-24
最終更新日2024-09-04
実験手法ELECTRON MICROSCOPY (3.73 Å)
主引用文献Structural basis for intermodular communication in assembly-line polyketide biosynthesis.
Nat.Chem.Biol., 2024
9F48
DownloadVisualize
BU of 9f48 by Molmil
KS + AT di-domain of polyketide synthase 13 in Mycobacterium tuberculosis
分子名称: Polyketide synthase Pks13
著者Johnston, H.E, Futterer, K.
登録日2024-04-26
公開日2024-05-22
実験手法ELECTRON MICROSCOPY (3.4 Å)
主引用文献CryoEM structure of the di-domain core of Mycobacterium tuberculosis polyketide synthase 13, essential for mycobacterial mycolic acid synthesis
To be published
8OII
DownloadVisualize
BU of 8oii by Molmil
Cryo-EM KSB domain of RhiE from Burkholderia rhizoxinica
分子名称: RhiE protein,Polyketide synthase domain protein RhiE
著者Capper, M.J, Koehnke, J.
登録日2023-03-22
公開日2024-04-03
実験手法ELECTRON MICROSCOPY (2.84 Å)
主引用文献Structural Analysis of a Chain-Branching Polyketide Synthase Module
To Be Published
8R0I
DownloadVisualize
BU of 8r0i by Molmil
Pseudomonas aeruginosa FabF C164A in complex with 3-amino-N-(1,5-dimethyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazol-4-yl)benzamide
分子名称: 1,2-ETHANEDIOL, 3-azanyl-N-(1,5-dimethyl-3-oxidanylidene-2-phenyl-pyrazol-4-yl)benzamide, 3-oxoacyl-[acyl-carrier-protein] synthase 2, ...
著者Yadrykhinsky, V, Brenk, R.
登録日2023-10-31
公開日2024-03-06
最終更新日2024-05-08
実験手法X-RAY DIFFRACTION (1.51 Å)
主引用文献Design, quality and validation of the EU-OPENSCREEN fragment library poised to a high-throughput screening collection.
Rsc Med Chem, 15, 2024
8R1V
DownloadVisualize
BU of 8r1v by Molmil
Pseudomonas aeruginosa FabF C164A in complex with N-(1,5-dimethyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazol-4-yl)-2-(4-methoxyphenoxy)acetamide
分子名称: 3-oxoacyl-[acyl-carrier-protein] synthase 2, DIMETHYL SULFOXIDE, FORMIC ACID, ...
著者Yadrykhinsky, V, Brenk, R.
登録日2023-11-02
公開日2024-03-06
最終更新日2024-05-08
実験手法X-RAY DIFFRACTION (2.087 Å)
主引用文献Design, quality and validation of the EU-OPENSCREEN fragment library poised to a high-throughput screening collection.
Rsc Med Chem, 15, 2024
8CG5
DownloadVisualize
BU of 8cg5 by Molmil
The ACP crosslinked to the KS of the cercosporin fungal non-reducing polyketide synthase (NR-PKS) CTB1 (SAT-KS:ACP-MAT)
分子名称: Acyl carrier protein (ACP) of Non-reducing polyketide synthase CTB1, Non-reducing polyketide synthase CTB1, N~3~-[(2R)-2-hydroxy-3,3-dimethyl-4-(phosphonooxy)butanoyl]-N-[2-(propanoylamino)ethyl]-beta-alaninamide
著者Munoz-Hernandez, H, Tittes, Y.U, Maier, T.
登録日2023-02-03
公開日2024-02-21
実験手法ELECTRON MICROSCOPY (2.7 Å)
主引用文献CryoEM structure of ACP crosslinked to KS of the cercosporin fungal non-reducing polyketide synthase (NR-PKS) CTB1 (SAT-KS:ACP-MAT) at 2.7 Angstroms resolution
To Be Published
8CG4
DownloadVisualize
BU of 8cg4 by Molmil
The organise full-length structure of the fungal non-reducing polyketide synthase (NR-PKS) PksA
分子名称: Norsolorinic acid synthase
著者Munoz-Hernandez, H, Maier, T.
登録日2023-02-03
公開日2024-02-21
実験手法ELECTRON MICROSCOPY (2.6 Å)
主引用文献CryoEM structure of the Aspergilus sp. fungal non-reducing polyketide synthase (NR-PKS) PksA at 2.6 Angstroms resolution
To Be Published
8CG6
DownloadVisualize
BU of 8cg6 by Molmil
The ACP crosslinked to the SAT of the cercosporin fungal non-reducing polyketide synthase (NR-PKS) CTB1 (ACP:SAT-KS-MAT)
分子名称: Acyl carrier protein (ACP) of Non-reducing polyketide synthase CTB1, Non-reducing polyketide synthase CTB1, N~3~-[(2R)-2-hydroxy-3,3-dimethyl-4-(phosphonooxy)butanoyl]-N-[2-(propanoylamino)ethyl]-beta-alaninamide
著者Munoz-Hernandez, H, Tittes, Y.U, Maier, T.
登録日2023-02-03
公開日2024-02-21
実験手法ELECTRON MICROSCOPY (3.4 Å)
主引用文献CryoEM structure of ACP crosslinked to SAT of the cercosporin fungal non-reducing polyketide synthase (NR-PKS) CTB1 (ACP:SAT-KS-MAT) at 3.4 Angstroms resolution
To Be Published
8PJ0
DownloadVisualize
BU of 8pj0 by Molmil
Pseudomonas aeruginosa FabF C164A mutant in complex with N-(1,5-dimethyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazol-4-yl)-3-methylbutanamide
分子名称: 3-oxoacyl-[acyl-carrier-protein] synthase 2, DIMETHYL SULFOXIDE, FORMIC ACID, ...
著者Georgiou, C, Brenk, R, Espeland, L.O.
登録日2023-06-22
公開日2024-02-21
最終更新日2024-05-08
実験手法X-RAY DIFFRACTION (1.7 Å)
主引用文献Design, quality and validation of the EU-OPENSCREEN fragment library poised to a high-throughput screening collection.
Rsc Med Chem, 15, 2024
8BY8
DownloadVisualize
BU of 8by8 by Molmil
The cercosporin fungal non-reducing polyketide synthase (NR-PKS) CTB1 (SAT-KS-MAT)
分子名称: Non-reducing polyketide synthase CTB1
著者Munoz-Hernandez, H, Maier, T.
登録日2022-12-12
公開日2024-01-10
実験手法ELECTRON MICROSCOPY (2.5 Å)
主引用文献The cercosporin fungal non-reducing polyketide synthase (NR-PKS) CTB1 (SAT-KS-MAT) at 2.5 Angstroms resolution
To Be Published
8CN7
DownloadVisualize
BU of 8cn7 by Molmil
Pa.FabF-C164Q in complex with platencin
分子名称: 2,4-dihydroxy-3-({3-[(2S,4aS,8S,8aR)-8-methyl-3-methylidene-7-oxo-1,3,4,7,8,8a-hexahydro-2H-2,4a-ethanonaphthalen-8-yl]propanoyl}amino)benzoic acid, 3-oxoacyl-[acyl-carrier-protein] synthase 2, DIMETHYL SULFOXIDE
著者Georgiou, C, Brenk, R.
登録日2023-02-22
公開日2024-01-10
実験手法X-RAY DIFFRACTION (2.1 Å)
主引用文献New starting points for antibiotics targeting P. aeruginosa FabF discovered by crystallographic fragment screening followed by hit expansion
Chemrxiv, 2023
8COU
DownloadVisualize
BU of 8cou by Molmil
Pa.FabF-C164Q in complex with 3-acetamido-4-methoxybenzoic acid
分子名称: 3-acetamido-4-methoxy-benzoic acid, 3-oxoacyl-[acyl-carrier-protein] synthase 2, DIMETHYL SULFOXIDE, ...
著者Georgiou, C, Brenk, R.
登録日2023-02-28
公開日2024-01-10
実験手法X-RAY DIFFRACTION (1.68 Å)
主引用文献New starting points for antibiotics targeting P. aeruginosa FabF discovered by crystallographic fragment screening followed by hit expansion
Chemrxiv, 2023
8CN5
DownloadVisualize
BU of 8cn5 by Molmil
Pa.FabF-C164Q in complex with propan-2-yl 1~{H}-pyrazole-3-carboxylate
分子名称: 3-oxoacyl-[acyl-carrier-protein] synthase 2, DIMETHYL SULFOXIDE, PHOSPHATE ION, ...
著者Georgiou, C, Brenk, R.
登録日2023-02-22
公開日2024-01-10
実験手法X-RAY DIFFRACTION (1.93 Å)
主引用文献New starting points for antibiotics targeting P. aeruginosa FabF discovered by crystallographic fragment screening followed by hit expansion
Chemrxiv, 2023
8COV
DownloadVisualize
BU of 8cov by Molmil
Pa.FabF-C164Q in complex with 6-chloro-2-methyl-1H-indole-5-carboxylic acid
分子名称: 3-oxoacyl-[acyl-carrier-protein] synthase 2, 6-chloranyl-2-methyl-1~{H}-indole-5-carboxylic acid, DIMETHYL SULFOXIDE, ...
著者Georgiou, C, Brenk, R, Espeland, L.O.
登録日2023-02-28
公開日2024-01-10
実験手法X-RAY DIFFRACTION (1.8 Å)
主引用文献New starting points for antibiotics targeting P. aeruginosa FabF discovered by crystallographic fragment screening followed by hit expansion
Chemrxiv, 2023
8CN4
DownloadVisualize
BU of 8cn4 by Molmil
Pa.FabF-C164Q in complex with 5-acetamido-2-chlorobenzoic acid
分子名称: 3-oxoacyl-[acyl-carrier-protein] synthase 2, 5-acetamido-2-chloranyl-benzoic acid, DIMETHYL SULFOXIDE, ...
著者Georgiou, C, Brenk, R.
登録日2023-02-21
公開日2024-01-10
実験手法X-RAY DIFFRACTION (1.67 Å)
主引用文献New starting points for antibiotics targeting P. aeruginosa FabF discovered by crystallographic fragment screening followed by hit expansion
Chemrxiv, 2023
8CN8
DownloadVisualize
BU of 8cn8 by Molmil
apo Pseudomonas aeruginosa FabF C164A mutant
分子名称: 3-oxoacyl-[acyl-carrier-protein] synthase 2
著者Georgiou, C, Brenk, R, Espeland, L.O.
登録日2023-02-22
公開日2024-01-10
実験手法X-RAY DIFFRACTION (1.8 Å)
主引用文献New starting points for antibiotics targeting P. aeruginosa FabF discovered by crystallographic fragment screening followed by hit expansion
Chemrxiv, 2023
8CNE
DownloadVisualize
BU of 8cne by Molmil
Pa.FabF-C164A in complex with N-(propan-2-yl)-1H-pyrazole-3-carboxamide
分子名称: 3-oxoacyl-[acyl-carrier-protein] synthase 2, DIMETHYL SULFOXIDE, FORMIC ACID, ...
著者Georgiou, C, Brenk, R, Espeland, L.O.
登録日2023-02-22
公開日2024-01-10
実験手法X-RAY DIFFRACTION (1.57 Å)
主引用文献New starting points for antibiotics targeting P. aeruginosa FabF discovered by crystallographic fragment screening followed by hit expansion
Chemrxiv, 2023
8CNG
DownloadVisualize
BU of 8cng by Molmil
Pa.FabF-C164Q in complex with ~{N}-cyclopentyl-3-methyl-1~{H}-pyrazole-5-carboxamide
分子名称: 3-oxoacyl-[acyl-carrier-protein] synthase 2, DIMETHYL SULFOXIDE, MAGNESIUM ION, ...
著者Georgiou, C, Brenk, R.
登録日2023-02-22
公開日2024-01-10
実験手法X-RAY DIFFRACTION (2.1 Å)
主引用文献New starting points for antibiotics targeting P. aeruginosa FabF discovered by crystallographic fragment screening followed by hit expansion
Chemrxiv, 2023
8CN2
DownloadVisualize
BU of 8cn2 by Molmil
Pa.FabF-C164Q in complex with N-isobutyl-1H-pyrazole-3-carboxamide
分子名称: 3-oxoacyl-[acyl-carrier-protein] synthase 2, DIMETHYL SULFOXIDE, ~{N}-(2-methylpropyl)-1~{H}-pyrazole-3-carboxamide
著者Georgiou, C, Brenk, R.
登録日2023-02-21
公開日2024-01-10
実験手法X-RAY DIFFRACTION (1.88 Å)
主引用文献New starting points for antibiotics targeting P. aeruginosa FabF discovered by crystallographic fragment screening followed by hit expansion
Chemrxiv, 2023
8PFZ
DownloadVisualize
BU of 8pfz by Molmil
Pseudomonas aeruginosa FabF C164A mutant in complex with(S)-2-(1H-pyrazole-3-carboxamido)butanoic acid
分子名称: (2~{S})-2-(1~{H}-pyrazol-3-ylcarbonylamino)butanoic acid, 3-oxoacyl-[acyl-carrier-protein] synthase 2, CHLORIDE ION, ...
著者Georgiou, C, Brenk, R, Yadrykhinsky, V, Espeland, L.O.
登録日2023-06-17
公開日2024-01-10
実験手法X-RAY DIFFRACTION (1.78 Å)
主引用文献New starting points for antibiotics targeting P. aeruginosa FabF discovered by crystallographic fragment screening followed by hit expansion
Chemrxiv, 2023
8PD1
DownloadVisualize
BU of 8pd1 by Molmil
Pseudomonas aeruginosa FabF C164A mutant in complex with N-isopropyl-1H-imidazole-4-carboxamide
分子名称: 3-oxoacyl-[acyl-carrier-protein] synthase 2, CHLORIDE ION, DIMETHYL SULFOXIDE, ...
著者Georgiou, C, Brenk, R, Yadrykhinsky, V, Espeland, L.O.
登録日2023-06-11
公開日2024-01-10
実験手法X-RAY DIFFRACTION (1.87 Å)
主引用文献New starting points for antibiotics targeting P. aeruginosa FabF discovered by crystallographic fragment screening followed by hit expansion
Chemrxiv, 2023

225158

件を2024-09-18に公開中

PDB statisticsPDBj update infoContact PDBjnumon