8CNE

Pa.FabF-C164A in complex with N-(propan-2-yl)-1H-pyrazole-3-carboxamide

Summary for 8CNE

• Entry DOI: 10.2210/pdb8cne/pdb
• Related: 8CN8
• Descriptor: 3-oxoacyl-[acyl-carrier-protein] synthase 2, DIMETHYL SULFOXIDE, N-(propan-2-yl)-1H-pyrazole-3-carboxamide, ... (6 entities in total)
• Functional Keywords: inhibitor, protein-ligand complex, fabf, transferase
• Biological source: Pseudomonas aeruginosa
• Total number of polymer chains: 2
• Total formula weight: 89295.54

Authors

Georgiou, C.,Brenk, R.,Espeland, L.O. (deposition date: 2023-02-22, release date: 2024-01-10)

• Primary citation: Georgiou, C.,Espeland, L.O.,Bukya, H.,Yadrykhinsky, V.,Haug, B.E.,Mainkar, P.,Brenk, R.; New starting points for antibiotics targeting P. aeruginosa FabF discovered by crystallographic fragment screening followed by hit expansion; Chemrxiv, 2023; DOI: 10.26434/chemrxiv-2023-cwk25

Experimental method

X-RAY DIFFRACTION (1.57 Å)