8CN5

Pa.FabF-C164Q in complex with propan-2-yl 1~{H}-pyrazole-3-carboxylate

Summary for 8CN5

• Entry DOI: 10.2210/pdb8cn5/pdb
• Related: 8CN4
• Descriptor: 3-oxoacyl-[acyl-carrier-protein] synthase 2, DIMETHYL SULFOXIDE, PHOSPHATE ION, ... (5 entities in total)
• Functional Keywords: inhibitor, transferase, fabf, complex
• Biological source: Pseudomonas aeruginosa
• Total number of polymer chains: 2
• Total formula weight: 89002.06

Authors

Georgiou, C.,Brenk, R. (deposition date: 2023-02-22, release date: 2024-01-10)

• Primary citation: Georgiou, C.,Espeland, L.O.,Bukya, H.,Yadrykhinsky, V.,Haug, B.E.,Mainkar, P.,Brenk, R.; New starting points for antibiotics targeting P. aeruginosa FabF discovered by crystallographic fragment screening followed by hit expansion; Chemrxiv, 2023; DOI: 10.26434/chemrxiv-2023-cwk25

Experimental method

X-RAY DIFFRACTION (1.93 Å)