8PD1

Pseudomonas aeruginosa FabF C164A mutant in complex with N-isopropyl-1H-imidazole-4-carboxamide

Summary for 8PD1

• Entry DOI: 10.2210/pdb8pd1/pdb
• Related: 8CNE
• Descriptor: 3-oxoacyl-[acyl-carrier-protein] synthase 2, DIMETHYL SULFOXIDE, PHOSPHATE ION, ... (7 entities in total)
• Functional Keywords: inhibitor, protein-ligand complex, fabf, transferase
• Biological source: Pseudomonas aeruginosa
• Total number of polymer chains: 2
• Total formula weight: 89748.14

Authors

Georgiou, C.,Brenk, R.,Yadrykhinsky, V.,Espeland, L.O. (deposition date: 2023-06-11, release date: 2024-01-10)

• Primary citation: Georgiou, C.,Espeland, L.O.,Bukya, H.,Yadrykhinsky, V.,Haug, B.E.,Mainkar, P.,Brenk, R.; New starting points for antibiotics targeting P. aeruginosa FabF discovered by crystallographic fragment screening followed by hit expansion; Chemrxiv, 2023; DOI: 10.26434/chemrxiv-2023-cwk25

Experimental method

X-RAY DIFFRACTION (1.87 Å)