4KBO
| Crystal structure of the human Mortalin (GRP75) ATPase domain in the apo form | Descriptor: | SODIUM ION, Stress-70 protein, mitochondrial | Authors: | Amick, J, Page, R.C, Nix, J.C, Misra, S. | Deposit date: | 2013-04-23 | Release date: | 2014-04-02 | Last modified: | 2023-09-20 | Method: | X-RAY DIFFRACTION (2.8 Å) | Cite: | Crystal structure of the nucleotide-binding domain of mortalin, the mitochondrial Hsp70 chaperone. Protein Sci., 23, 2014
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2BPR
| NMR STRUCTURE OF THE SUBSTRATE BINDING DOMAIN OF DNAK, 25 STRUCTURES | Descriptor: | DNAK | Authors: | Wang, H, Kurochkin, A.V, Pang, Y, Hu, W, Flynn, G.C, Zuiderweg, E.R.P. | Deposit date: | 1998-08-11 | Release date: | 1999-03-02 | Last modified: | 2024-05-22 | Method: | SOLUTION NMR | Cite: | NMR solution structure of the 21 kDa chaperone protein DnaK substrate binding domain: a preview of chaperone-protein interaction. Biochemistry, 37, 1998
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4B9Q
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1S3X
| The crystal structure of the human Hsp70 ATPase domain | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, CALCIUM ION, Heat shock 70 kDa protein 1, ... | Authors: | Sriram, M, Osipiuk, J, Freeman, B, Morimoto, R.I, Joachimiak, A. | Deposit date: | 2004-01-14 | Release date: | 2004-01-20 | Last modified: | 2023-08-23 | Method: | X-RAY DIFFRACTION (1.84 Å) | Cite: | Human Hsp70 molecular chaperone binds two calcium ions within the ATPase domain Structure, 5, 1997
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1U00
| HscA substrate binding domain complexed with the IscU recognition peptide ELPPVKIHC | Descriptor: | Chaperone protein hscA, IscU recognition peptide | Authors: | Cupp-Vickery, J.R, Peterson, J.C, Ta, D.T, Vickery, L.E. | Deposit date: | 2004-07-12 | Release date: | 2004-10-05 | Last modified: | 2024-04-03 | Method: | X-RAY DIFFRACTION (1.95 Å) | Cite: | Crystal Structure of the Molecular Chaperone HscA Substrate Binding Domain Complexed with the IscU Recognition Peptide ELPPVKIHC. J.Mol.Biol., 342, 2004
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6NHK
| Mortalin nucleotide binding domain in the ADP-bound state | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, GLYCEROL, MAGNESIUM ION, ... | Authors: | Page, R.C, Moseng, M.A, Nix, J.C. | Deposit date: | 2018-12-23 | Release date: | 2019-04-17 | Last modified: | 2023-10-11 | Method: | X-RAY DIFFRACTION (2.777 Å) | Cite: | Biophysical Consequences of EVEN-PLUS Syndrome Mutations for the Function of Mortalin. J.Phys.Chem.B, 123, 2019
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2KHO
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7PLK
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3DPP
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3DPQ
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5TKY
| Crystal structure of the co-translational Hsp70 chaperone Ssb in the ATP-bound, open conformation | Descriptor: | ADENOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, Putative uncharacterized protein | Authors: | Gumiero, A, Gese, G.V, Weyer, F.A, Lapouge, K, Sinning, I. | Deposit date: | 2016-10-10 | Release date: | 2016-11-16 | Last modified: | 2024-01-17 | Method: | X-RAY DIFFRACTION (2.6 Å) | Cite: | Interaction of the cotranslational Hsp70 Ssb with ribosomal proteins and rRNA depends on its lid domain. Nat Commun, 7, 2016
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2E8A
| Crystal structure of the human Hsp70 ATPase domain in complex with AMP-PNP | Descriptor: | Heat shock 70kDa protein 1A, MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER | Authors: | Shida, M, Ishii, R, Takagi, T, Kishishita, S, Shirouzu, M, Yokoyama, S, RIKEN Structural Genomics/Proteomics Initiative (RSGI) | Deposit date: | 2007-01-19 | Release date: | 2008-01-22 | Last modified: | 2023-10-25 | Method: | X-RAY DIFFRACTION (1.77 Å) | Cite: | Direct inter-subdomain interactions switch between the closed and open forms of the Hsp70 nucleotide-binding domain in the nucleotide-free state. Acta Crystallogr.,Sect.D, 66, 2010
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6P2U
| Structure of Mortalin-NBD with N6-propargyladenosine-5'-diphosphate | Descriptor: | 9-{5-O-[(S)-hydroxy(phosphonooxy)phosphoryl]-alpha-D-ribofuranosyl}-N-(prop-2-yn-1-yl)-9H-purin-6-amine, MAGNESIUM ION, PHOSPHATE ION, ... | Authors: | Moseng, M.A, Page, R.C. | Deposit date: | 2019-05-22 | Release date: | 2019-06-19 | Last modified: | 2023-10-11 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | 2- and N6-functionalized adenosine-5'-diphosphate analogs for the inhibition of mortalin. Febs Lett., 593, 2019
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7RAX
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2E88
| Crystal structure of the human Hsp70 ATPase domain in the apo form | Descriptor: | Heat shock 70kDa protein 1A, ZINC ION | Authors: | Shida, M, Ishii, R, Takagi, T, Kishishita, S, Shirouzu, M, Yokoyama, S, RIKEN Structural Genomics/Proteomics Initiative (RSGI) | Deposit date: | 2007-01-19 | Release date: | 2008-01-22 | Last modified: | 2023-10-25 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | Direct inter-subdomain interactions switch between the closed and open forms of the Hsp70 nucleotide-binding domain in the nucleotide-free state. Acta Crystallogr.,Sect.D, 66, 2010
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6PMT
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2V7Z
| Crystal structure of the 70-kDa heat shock cognate protein from Rattus norvegicus in post-ATP hydrolysis state | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, HEAT SHOCK COGNATE 71 KDA PROTEIN, PHOSPHATE ION | Authors: | Chang, Y.-W, Sun, Y.-J, Wang, C, Hsiao, C.-D. | Deposit date: | 2007-08-02 | Release date: | 2008-04-08 | Last modified: | 2023-12-13 | Method: | X-RAY DIFFRACTION (3.5 Å) | Cite: | Crystal Structures of the 70-kDa Heat Shock Proteins in Domain Disjoining Conformation. J.Biol.Chem., 283, 2008
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5UMB
| Crystal structure of ATPase domain of Malaria GRP78 with ADP bound | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, Chaperone DnaK, MAGNESIUM ION, ... | Authors: | Chen, Y, Antoshchenko, T, Pizarro, J.C, Song, J.H, Park, H. | Deposit date: | 2017-01-26 | Release date: | 2022-07-27 | Last modified: | 2023-10-04 | Method: | X-RAY DIFFRACTION (2.3 Å) | Cite: | Repurposing drugs to target the malaria parasite unfolding protein response. Sci Rep, 8, 2018
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2V7Y
| Crystal structure of the molecular chaperone DnaK from Geobacillus kaustophilus HTA426 in post-ATP hydrolysis state | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, CHAPERONE PROTEIN DNAK, MAGNESIUM ION, ... | Authors: | Chang, Y.-W, Sun, Y.-J, Wang, C, Hsiao, C.-D. | Deposit date: | 2007-08-02 | Release date: | 2008-04-08 | Last modified: | 2023-12-13 | Method: | X-RAY DIFFRACTION (2.37 Å) | Cite: | Crystal Structures of the 70-kDa Heat Shock Proteins in Domain Disjoining Conformation. J.Biol.Chem., 283, 2008
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5XI9
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5XIR
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1YUW
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6RZQ
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6SR6
| Crystal structure of the RAC core with a pseudo substrate bound to Ssz1 SBD | Descriptor: | ADENOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, Putative heat shock protein, ... | Authors: | Valentin Gese, G, Lapouge, K, Kopp, J, Sinning, I. | Deposit date: | 2019-09-05 | Release date: | 2020-03-25 | Last modified: | 2024-01-24 | Method: | X-RAY DIFFRACTION (2.5 Å) | Cite: | The ribosome-associated complex RAC serves in a relay that directs nascent chains to Ssb. Nat Commun, 11, 2020
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6S02
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