4L0Y
 
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4L18
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4L0Z
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1LJM
 | | DNA recognition is mediated by conformational transition and by DNA bending | | 分子名称: | CHLORIDE ION, RUNX1 transcription factor | | 著者 | Bartfeld, D, Shimon, L, Couture, G.C, Rabinovich, D, Frolow, F, Levanon, D, Groner, Y, Shakked, Z. | | 登録日 | 2002-04-22 | | 公開日 | 2002-11-06 | | 最終更新日 | 2023-08-16 | | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | | 主引用文献 | DNA Recognition by the RUNX1 Transcription Factor Is Mediated by an Allosteric Transition in the RUNT Domain and by DNA Bending.
Structure, 10
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1EAQ
 | | The RUNX1 Runt domain at 1.25A resolution: A structural switch and specifically bound chloride ions modulate DNA binding | | 分子名称: | CHLORIDE ION, RUNT-RELATED TRANSCRIPTION FACTOR 1 | | 著者 | Backstrom, S, Wolf-Watz, M, Grundstrom, C, Hard, T, Grundstrom, T, Sauer, U.H. | | 登録日 | 2001-07-14 | | 公開日 | 2002-09-12 | | 実験手法 | X-RAY DIFFRACTION (1.25 Å) | | 主引用文献 | The Runx1 Runt Domain at 1.25 A Resolution: A Structural Switch and Specifically Bound Chloride Ions Modulate DNA Binding
J.Mol.Biol., 322, 2002
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1EAO
 | | THE RUNX1 Runt domain at 1.4A resolution: a structural switch and specifically bound chloride ions modulate DNA binding | | 分子名称: | BROMIDE ION, RUNT-RELATED TRANSCRIPTION FACTOR 1 | | 著者 | Backstrom, S, Wolf-Watz, M, Grundstrom, C, Hard, T.H, Grundstrom, T, Sauer, U.H. | | 登録日 | 2001-07-14 | | 公開日 | 2002-09-12 | | 実験手法 | X-RAY DIFFRACTION (1.4 Å) | | 主引用文献 | The Runx1 Runt Domain at 1.25A Resolution: A Structural Switch and Specifically Bound Chloride Ions Modulate DNA Binding
J.Mol.Biol., 322, 2002
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1EAN
 | | THE RUNX1 Runt domain at 1.70A resolution: A structural switch and specifically bound chloride ions modulate DNA binding | | 分子名称: | CHLORIDE ION, RUNT-RELATED TRANSCRIPTION FACTOR 1 | | 著者 | Backstrom, S, Wolf-Watz, M, Grundstrom, C, Hard, T, Grundstrom, T, Sauer, U.H. | | 登録日 | 2001-07-13 | | 公開日 | 2002-09-12 | | 最終更新日 | 2023-12-13 | | 実験手法 | X-RAY DIFFRACTION (1.7 Å) | | 主引用文献 | The Runx1 Runt Domain at 1.25 A Resolution: A Structural Switch and Specifically Bound Chloride Ions Modulate DNA Binding
J.Mol.Biol., 322, 2002
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1H9D
 | | Aml1/cbf-beta/dna complex | | 分子名称: | CORE-BINDING FACTOR ALPHA SUBUNIT1, CORE-BINDING FACTOR CBF-BETA, DNA (5'-(*CP*AP*AP*CP*CP*GP*CP*AP*AP*C)-3'), ... | | 著者 | Bravo, J, Warren, A.J. | | 登録日 | 2001-03-07 | | 公開日 | 2001-03-31 | | 最終更新日 | 2023-12-13 | | 実験手法 | X-RAY DIFFRACTION (2.6 Å) | | 主引用文献 | The Leukemia-Associated Aml1 (Runx1)-Cbfbeta Complex Functions as a DNA-Induced Molecular Clamp
Nat.Struct.Biol., 8, 2001
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3WTW
 | | Crystal structure of the complex comprised of ETS1(K167A), RUNX1, CBFBETA, and the tcralpha gene enhancer DNA | | 分子名称: | Core-binding factor subunit beta, DNA (5'-D(*AP*GP*AP*GP*GP*AP*TP*GP*TP*GP*GP*CP*TP*TP*C)-3'), DNA (5'-D(*GP*AP*AP*GP*CP*CP*AP*CP*AP*TP*CP*CP*TP*CP*T)-3'), ... | | 著者 | Shiina, M, Hamada, K, Ogata, K. | | 登録日 | 2014-04-21 | | 公開日 | 2014-08-20 | | 最終更新日 | 2023-11-08 | | 実験手法 | X-RAY DIFFRACTION (2.9 Å) | | 主引用文献 | A novel allosteric mechanism on protein-DNA interactions underlying the phosphorylation-dependent regulation of Ets1 target gene expressions.
J.Mol.Biol., 427, 2015
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3WTY
 | | Crystal structure of the complex comprised of ETS1(G333P), RUNX1, CBFBETA, and the tcralpha gene enhancer DNA | | 分子名称: | Core-binding factor subunit beta, DNA (5'-D(*AP*GP*AP*GP*GP*AP*TP*GP*TP*GP*GP*CP*TP*TP*C)-3'), DNA (5'-D(*GP*AP*AP*GP*CP*CP*AP*CP*AP*TP*CP*CP*TP*CP*T)-3'), ... | | 著者 | Shiina, M, Hamada, K, Ogata, K. | | 登録日 | 2014-04-21 | | 公開日 | 2014-08-13 | | 最終更新日 | 2023-11-08 | | 実験手法 | X-RAY DIFFRACTION (2.7 Å) | | 主引用文献 | A novel allosteric mechanism on protein-DNA interactions underlying the phosphorylation-dependent regulation of Ets1 target gene expressions.
J.Mol.Biol., 427, 2015
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3WTX
 | | Crystal structure of the complex comprised of ETS1(Y329A), RUNX1, CBFBETA, and the tcralpha gene enhancer DNA | | 分子名称: | Core-binding factor subunit beta, DNA (5'-D(*AP*GP*AP*GP*GP*AP*TP*GP*TP*GP*GP*CP*TP*TP*C)-3'), DNA (5'-D(*GP*AP*AP*GP*CP*CP*AP*CP*AP*TP*CP*CP*TP*CP*T)-3'), ... | | 著者 | Shiina, M, Hamada, K, Ogata, K. | | 登録日 | 2014-04-21 | | 公開日 | 2014-08-13 | | 最終更新日 | 2023-11-08 | | 実験手法 | X-RAY DIFFRACTION (2.8 Å) | | 主引用文献 | A novel allosteric mechanism on protein-DNA interactions underlying the phosphorylation-dependent regulation of Ets1 target gene expressions.
J.Mol.Biol., 427, 2015
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3WTV
 | | Crystal structure of the complex comprised of ETS1(V170G), RUNX1, CBFBETA, and the tcralpha gene enhancer DNA | | 分子名称: | Core-binding factor subunit beta, DNA (5'-D(*AP*GP*AP*GP*GP*AP*TP*GP*TP*GP*GP*CP*TP*TP*C)-3'), DNA (5'-D(*GP*AP*AP*GP*CP*CP*AP*CP*AP*TP*CP*CP*TP*CP*T)-3'), ... | | 著者 | Shiina, M, Hamada, K, Ogata, K. | | 登録日 | 2014-04-21 | | 公開日 | 2014-08-20 | | 最終更新日 | 2023-11-08 | | 実験手法 | X-RAY DIFFRACTION (2.7 Å) | | 主引用文献 | A novel allosteric mechanism on protein-DNA interactions underlying the phosphorylation-dependent regulation of Ets1 target gene expressions.
J.Mol.Biol., 427, 2015
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3WTT
 | | Crystal structure of the complex comprised of phosphorylated ETS1, RUNX1, CBFBETA, and the tcralpha gene enhancer DNA | | 分子名称: | 5'-D(*AP*GP*AP*GP*GP*AP*TP*GP*TP*GP*GP*CP*TP*TP*C)-3', 5'-D(*GP*AP*AP*GP*CP*CP*AP*CP*AP*TP*CP*CP*TP*CP*T)-3', Core-binding factor subunit beta, ... | | 著者 | Shiina, M, Hamada, K, Ogata, K. | | 登録日 | 2014-04-21 | | 公開日 | 2014-08-13 | | 最終更新日 | 2023-11-08 | | 実験手法 | X-RAY DIFFRACTION (2.35 Å) | | 主引用文献 | A novel allosteric mechanism on protein-DNA interactions underlying the phosphorylation-dependent regulation of Ets1 target gene expressions.
J.Mol.Biol., 427, 2015
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3WTS
 | | Crystal structure of the complex comprised of ETS1, RUNX1, CBFBETA, and the tcralpha gene enhancer DNA | | 分子名称: | 5'-D(*AP*GP*AP*GP*GP*AP*TP*GP*TP*GP*GP*CP*TP*TP*C)-3', 5'-D(*GP*AP*AP*GP*CP*CP*AP*CP*AP*TP*CP*CP*TP*CP*T)-3', Core-binding factor subunit beta, ... | | 著者 | Shiina, M, Hamada, K, Ogata, K. | | 登録日 | 2014-04-21 | | 公開日 | 2014-08-13 | | 最終更新日 | 2023-11-08 | | 実験手法 | X-RAY DIFFRACTION (2.35 Å) | | 主引用文献 | A novel allosteric mechanism on protein-DNA interactions underlying the phosphorylation-dependent regulation of Ets1 target gene expressions.
J.Mol.Biol., 427, 2015
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3WTU
 | | Crystal structure of the complex comprised of ETS1 (V170A), RUNX1, CBFBETA, and the tcralpha gene enhancer DNA | | 分子名称: | Core-binding factor subunit beta, DNA (5'-D(*AP*GP*AP*GP*GP*AP*TP*GP*TP*GP*GP*CP*TP*TP*C)-3'), DNA (5'-D(*GP*AP*AP*GP*CP*CP*AP*CP*AP*TP*CP*CP*TP*CP*T)-3'), ... | | 著者 | Shiina, M, Hamada, K, Ogata, K. | | 登録日 | 2014-04-21 | | 公開日 | 2014-08-13 | | 最終更新日 | 2023-11-08 | | 実験手法 | X-RAY DIFFRACTION (2.7 Å) | | 主引用文献 | A novel allosteric mechanism on protein-DNA interactions underlying the phosphorylation-dependent regulation of Ets1 target gene expressions.
J.Mol.Biol., 427, 2015
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3WU1
 | | Crystal structure of the ETS1-RUNX1-DNA ternary complex | | 分子名称: | DNA (5'-D(*CP*AP*GP*AP*GP*GP*AP*TP*GP*TP*GP*GP*CP*TP*TP*C)-3'), DNA (5'-D(*GP*GP*AP*AP*GP*CP*CP*AP*CP*AP*TP*CP*CP*TP*CP*T)-3'), Protein C-ets-1, ... | | 著者 | Tahirov, T.H, Ogata, K. | | 登録日 | 2014-04-21 | | 公開日 | 2014-08-20 | | 最終更新日 | 2023-11-08 | | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | | 主引用文献 | A novel allosteric mechanism on protein-DNA interactions underlying the phosphorylation-dependent regulation of Ets1 target gene expressions.
J.Mol.Biol., 427, 2015
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2J6W
 | | R164N mutant of the RUNX1 Runt domain | | 分子名称: | CHLORIDE ION, RUNT-RELATED TRANSCRIPTION FACTOR 1 | | 著者 | Grembecka, J, Zhe, L, Lukasik, S.M, Liu, Y, Bielnicka, I, Bushweller, J.H, Speck, N.A. | | 登録日 | 2006-10-04 | | 公開日 | 2007-10-09 | | 最終更新日 | 2023-12-13 | | 実験手法 | X-RAY DIFFRACTION (2.6 Å) | | 主引用文献 | A Mutation in the S-Switch Region of the Runt Domain Alters the Dynamics of an Allosteric Network Responsible for Cbfbeta Regulation.
J.Mol.Biol., 364, 2006
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1XJY
 | | The crystal structures of the DNA binding sites of the RUNX1 transcription factor | | 分子名称: | 5'-D(*TP*CP*TP*GP*CP*GP*GP*TP*C)-3', 5'-D(*TP*GP*AP*CP*CP*GP*CP*AP*G)-3' | | 著者 | Kitayner, M, Rozenberg, H, Rabinovich, D, Shakked, Z. | | 登録日 | 2004-09-26 | | 公開日 | 2005-03-15 | | 最終更新日 | 2024-04-03 | | 実験手法 | X-RAY DIFFRACTION (2 Å) | | 主引用文献 | Structures of the DNA-binding site of Runt-domain transcription regulators.
Acta Crystallogr.,Sect.D, 61, 2005
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1XJX
 | | The crystal structures of the DNA binding sites of the RUNX1 transcription factor | | 分子名称: | 5'-D(*TP*CP*TP*GP*CP*GP*GP*TP*C)-3', 5'-D(*TP*GP*AP*CP*CP*GP*CP*AP*G)-3' | | 著者 | Kitayner, M, Rozenberg, H, Rabinovich, D, Shakked, Z. | | 登録日 | 2004-09-26 | | 公開日 | 2005-03-15 | | 最終更新日 | 2024-04-03 | | 実験手法 | X-RAY DIFFRACTION (1.7 Å) | | 主引用文献 | Structures of the DNA-binding site of Runt-domain transcription regulators.
Acta Crystallogr.,Sect.D, 61, 2005
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1CMO
 | | IMMUNOGLOBULIN MOTIF DNA-RECOGNITION AND HETERODIMERIZATION FOR THE PEBP2/CBF RUNT-DOMAIN | | 分子名称: | POLYOMAVIRUS ENHANCER BINDING PROTEIN 2 | | 著者 | Nagata, T, Gupta, V, Sorce, D, Kim, W.Y, Sali, A, Chait, B.T, Shigesada, K, Ito, Y, Werner, M.H. | | 登録日 | 1999-05-11 | | 公開日 | 2000-01-05 | | 最終更新日 | 2023-12-27 | | 実験手法 | SOLUTION NMR | | 主引用文献 | Immunoglobulin motif DNA recognition and heterodimerization of the PEBP2/CBF Runt domain.
Nat.Struct.Biol., 6, 1999
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1IO4
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1CO1
 | | FOLD OF THE CBFA | | 分子名称: | CORE BINDING FACTOR ALPHA | | 著者 | Berardi, M.J, Bushweller, J.H. | | 登録日 | 1999-05-31 | | 公開日 | 2000-06-07 | | 最終更新日 | 2023-12-27 | | 実験手法 | SOLUTION NMR | | 主引用文献 | The Ig fold of the core binding factor alpha Runt domain is a member of a family of structurally and functionally related Ig-fold DNA-binding domains.
Structure Fold.Des., 7, 1999
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5T1J
 | | Crystal Structure of the Tbox DNA binding domain of the transcription factor T-bet | | 分子名称: | DNA, T-box transcription factor TBX21 | | 著者 | Liu, C.F, Brandt, G.S, Hoang, Q, Hwang, E.S, Naumova, N, Lazarevic, V, Dekker, J, Glimcher, L.H, Ringe, D, Petsko, G.A. | | 登録日 | 2016-08-19 | | 公開日 | 2016-10-26 | | 最終更新日 | 2023-12-27 | | 実験手法 | X-RAY DIFFRACTION (2.947 Å) | | 主引用文献 | Crystal structure of the DNA binding domain of the transcription factor T-bet suggests simultaneous recognition of distant genome sites.
Proc.Natl.Acad.Sci.USA, 113, 2016
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7TDW
 | | Structure of FOXP3-DNA complex | | 分子名称: | DNA (5'-D(*AP*AP*AP*TP*TP*TP*GP*TP*TP*TP*AP*CP*TP*C)-3'), DNA (5'-D(P*GP*AP*GP*TP*AP*AP*AP*CP*AP*AP*AP*TP*TP*T)-3'), Forkhead box P3 | | 著者 | Leng, F, Hur, S. | | 登録日 | 2022-01-03 | | 公開日 | 2022-08-10 | | 最終更新日 | 2023-10-18 | | 実験手法 | X-RAY DIFFRACTION (4 Å) | | 主引用文献 | The transcription factor FoxP3 can fold into two dimerization states with divergent implications for regulatory T cell function and immune homeostasis.
Immunity, 55, 2022
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7TDX
 | | Structure of FOXP3-DNA complex | | 分子名称: | DNA (5'-D(*AP*AP*AP*TP*TP*TP*GP*TP*TP*TP*AP*CP*TP*C)-3'), DNA (5'-D(P*GP*AP*GP*TP*AP*AP*AP*CP*AP*AP*AP*TP*TP*T)-3'), Forkhead box P3 | | 著者 | Leng, F, Hur, S. | | 登録日 | 2022-01-03 | | 公開日 | 2022-08-10 | | 最終更新日 | 2023-10-18 | | 実験手法 | X-RAY DIFFRACTION (3.1 Å) | | 主引用文献 | The transcription factor FoxP3 can fold into two dimerization states with divergent implications for regulatory T cell function and immune homeostasis.
Immunity, 55, 2022
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