1CO1

FOLD OF THE CBFA

Summary for 1CO1

Entry DOI	10.2210/pdb1co1/pdb
Descriptor	CORE BINDING FACTOR ALPHA (1 entity in total)
Functional Keywords	cbfa runt aml-1 runt domain, gene regulation
Biological source	Homo sapiens (human)
Cellular location	Nucleus: Q01196
Total number of polymer chains	1
Total formula weight	12694.49
Authors	Berardi, M.J.,Bushweller, J.H. (deposition date: 1999-05-31, release date: 2000-06-07, Last modification date: 2023-12-27)
Primary citation	Berardi, M.J.,Sun, C.,Zehr, M.,Abildgaard, F.,Peng, J.,Speck, N.A.,Bushweller, J.H. The Ig fold of the core binding factor alpha Runt domain is a member of a family of structurally and functionally related Ig-fold DNA-binding domains. Structure Fold.Des., 7:1247-1256, 1999 Cited by PubMed Abstract: CBFA is the DNA-binding subunit of the transcription factor complex called core binding factor, or CBF. Knockout of the Cbfa2 gene in mice leads to embryonic lethality and a profound block in hematopoietic development. Chromosomal disruptions of the human CBFA gene are associated with a large percentage of human leukemias. PubMed: 10545320 DOI: 10.1016/S0969-2126(00)80058-1 PDB entries with the same primary citation
Experimental method	SOLUTION NMR

Structure validation