7P9V
| Cryo EM structure of System XC- | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 4F2 cell-surface antigen heavy chain, Cystine/glutamate transporter | 著者 | Parker, J.L, Deme, J.C, Lea, S.M, Newstead, S. | 登録日 | 2021-07-28 | 公開日 | 2021-11-17 | 最終更新日 | 2022-02-02 | 実験手法 | ELECTRON MICROSCOPY (3.4 Å) | 主引用文献 | Molecular basis for redox control by the human cystine/glutamate antiporter system xc . Nat Commun, 12, 2021
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7P9U
| Cryo EM structure of System XC- in complex with glutamate | 分子名称: | 4F2 cell-surface antigen heavy chain, Cystine/glutamate transporter, GLUTAMIC ACID | 著者 | Parker, J.L, Deme, J.C, Lea, S.M, Newstead, S. | 登録日 | 2021-07-28 | 公開日 | 2021-11-17 | 最終更新日 | 2022-02-02 | 実験手法 | ELECTRON MICROSCOPY (3.7 Å) | 主引用文献 | Molecular basis for redox control by the human cystine/glutamate antiporter system xc . Nat Commun, 12, 2021
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6LID
| Heteromeric amino acid transporter b0,+AT-rBAT complex | 分子名称: | 1,2-DIACYL-GLYCEROL-3-SN-PHOSPHATE, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, ... | 著者 | Yan, R.H, Li, Y.N, Lei, J.L, Zhou, Q. | 登録日 | 2019-12-10 | 公開日 | 2020-04-29 | 最終更新日 | 2020-07-29 | 実験手法 | ELECTRON MICROSCOPY (2.7 Å) | 主引用文献 | Cryo-EM structure of the human heteromeric amino acid transporter b0,+AT-rBAT. Sci Adv, 6, 2020
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6LI9
| Heteromeric amino acid transporter b0,+AT-rBAT complex bound with Arginine | 分子名称: | 1,2-DIACYL-GLYCEROL-3-SN-PHOSPHATE, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ARGININE, ... | 著者 | Yan, R.H, Li, Y.N, Lei, J.L, Zhou, Q. | 登録日 | 2019-12-10 | 公開日 | 2020-04-29 | 最終更新日 | 2020-07-29 | 実験手法 | ELECTRON MICROSCOPY (2.3 Å) | 主引用文献 | Cryo-EM structure of the human heteromeric amino acid transporter b0,+AT-rBAT. Sci Adv, 6, 2020
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7NF8
| Ovine (b0,+AT-rBAT)2 hetero-tetramer, asymmetric unit, rigid-body fitted | 分子名称: | 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphocholine, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... | 著者 | Lee, Y, Kuehlbrandt, W. | 登録日 | 2021-02-05 | 公開日 | 2022-01-19 | 最終更新日 | 2022-06-08 | 実験手法 | ELECTRON MICROSCOPY (2.83 Å) | 主引用文献 | Ca 2+ -mediated higher-order assembly of heterodimers in amino acid transport system b 0,+ biogenesis and cystinuria. Nat Commun, 13, 2022
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7NF6
| Ovine b0,+AT-rBAT heterodimer | 分子名称: | 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphocholine, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... | 著者 | Lee, Y, Kuehlbrandt, W. | 登録日 | 2021-02-05 | 公開日 | 2022-01-19 | 最終更新日 | 2022-06-01 | 実験手法 | ELECTRON MICROSCOPY (3.05 Å) | 主引用文献 | Ca 2+ -mediated higher-order assembly of heterodimers in amino acid transport system b 0,+ biogenesis and cystinuria. Nat Commun, 13, 2022
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6IRS
| human LAT1-4F2hc complex incubated with JPH203 | 分子名称: | 1,2-DIACYL-GLYCEROL-3-SN-PHOSPHATE, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 4F2 cell-surface antigen heavy chain, ... | 著者 | Yan, R.H, Zhao, X, Lei, J.L, Zhou, Q. | 登録日 | 2018-11-14 | 公開日 | 2019-03-27 | 最終更新日 | 2020-07-29 | 実験手法 | ELECTRON MICROSCOPY (3.3 Å) | 主引用文献 | Structure of the human LAT1-4F2hc heteromeric amino acid transporter complex. Nature, 568, 2019
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6IRT
| human LAT1-4F2hc complex bound with BCH | 分子名称: | (1S,2S,4R)-2-aminobicyclo[2.2.1]heptane-2-carboxylic acid, 1,2-DIACYL-GLYCEROL-3-SN-PHOSPHATE, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... | 著者 | Yan, R.H, Zhao, X, Lei, J.L, Zhou, Q. | 登録日 | 2018-11-14 | 公開日 | 2019-03-27 | 最終更新日 | 2020-07-29 | 実験手法 | ELECTRON MICROSCOPY (3.5 Å) | 主引用文献 | Structure of the human LAT1-4F2hc heteromeric amino acid transporter complex. Nature, 568, 2019
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6JMQ
| LAT1-CD98hc complex bound to MEM-108 Fab | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 4F2 cell-surface antigen heavy chain, ... | 著者 | Lee, Y, Nishizawa, T, Kusakizako, T, Oda, K, Ishitani, R, Nakane, T, Nureki, O. | 登録日 | 2019-03-13 | 公開日 | 2019-06-19 | 最終更新日 | 2020-07-29 | 実験手法 | ELECTRON MICROSCOPY (3.31 Å) | 主引用文献 | Cryo-EM structure of the human L-type amino acid transporter 1 in complex with glycoprotein CD98hc. Nat.Struct.Mol.Biol., 26, 2019
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7CMH
| The LAT2-4F2hc complex in complex with tryptophan | 分子名称: | 1,2-DIACYL-GLYCEROL-3-SN-PHOSPHATE, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 4F2 cell-surface antigen heavy chain, ... | 著者 | Yan, R.H, Zhou, J.Y, Li, Y.N, Lei, J.L, Zhou, Q. | 登録日 | 2020-07-27 | 公開日 | 2020-12-23 | 実験手法 | ELECTRON MICROSCOPY (3.4 Å) | 主引用文献 | Structural insight into the substrate recognition and transport mechanism of the human LAT2-4F2hc complex. Cell Discov, 6, 2020
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7CMI
| The LAT2-4F2hc complex in complex with leucine | 分子名称: | 1,2-DIACYL-GLYCEROL-3-SN-PHOSPHATE, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 4F2 cell-surface antigen heavy chain, ... | 著者 | Yan, R.H, Zhou, J.Y, Li, Y.N, Lei, J.L, Zhou, Q. | 登録日 | 2020-07-27 | 公開日 | 2020-12-23 | 実験手法 | ELECTRON MICROSCOPY (2.9 Å) | 主引用文献 | Structural insight into the substrate recognition and transport mechanism of the human LAT2-4F2hc complex. Cell Discov, 6, 2020
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7CCS
| Consensus mutated xCT-CD98hc complex | 分子名称: | 4F2 cell-surface antigen heavy chain, Consensus mutated Anionic Amino Acid Transporter Light Chain, Xc- System | 著者 | Oda, K, Lee, Y, Takemoto, M, Yamashita, K, Nishizawa, T, Nureki, O. | 登録日 | 2020-06-17 | 公開日 | 2020-12-09 | 最終更新日 | 2020-12-16 | 実験手法 | ELECTRON MICROSCOPY (6.2 Å) | 主引用文献 | Consensus mutagenesis approach improves the thermal stability of system x c - transporter, xCT, and enables cryo-EM analyses. Protein Sci., 29, 2020
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7EPZ
| Overall structure of Erastin-bound xCT-4F2hc complex | 分子名称: | 1,2-DISTEAROYL-SN-GLYCERO-3-PHOSPHATE, 2-[(1S)-1-[4-[2-(4-chloranylphenoxy)ethanoyl]piperazin-1-yl]ethyl]-3-(2-ethoxyphenyl)quinazolin-4-one, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... | 著者 | Yan, R.H, Li, Y.N, Zhang, Y.Y, Chi, X.M, Zhou, Q. | 登録日 | 2021-04-28 | 公開日 | 2022-04-06 | 最終更新日 | 2022-07-13 | 実験手法 | ELECTRON MICROSCOPY (3.4 Å) | 主引用文献 | The structure of erastin-bound xCT-4F2hc complex reveals molecular mechanisms underlying erastin-induced ferroptosis. Cell Res., 32, 2022
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7DSL
| Overall structure of the LAT1-4F2hc bound with JX-078 | 分子名称: | (2~{S})-2-azanyl-7-[(2-phenylphenyl)methoxy]-3,4-dihydro-1~{H}-naphthalene-2-carboxylic acid, 1,2-DIACYL-GLYCEROL-3-SN-PHOSPHATE, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... | 著者 | Yan, R.H, Li, Y.N, Zhang, Y.Y, Zhong, X.Y, Zhou, Q. | 登録日 | 2020-12-31 | 公開日 | 2021-03-10 | 最終更新日 | 2022-06-29 | 実験手法 | ELECTRON MICROSCOPY (2.9 Å) | 主引用文献 | Mechanism of substrate transport and inhibition of the human LAT1-4F2hc amino acid transporter. Cell Discov, 7, 2021
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7DSQ
| Overall structure of the LAT1-4F2hc bound with 3,5-diiodo-L-tyrosine | 分子名称: | 1,2-DIACYL-GLYCEROL-3-SN-PHOSPHATE, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 3,5-DIIODOTYROSINE, ... | 著者 | Yan, R.H, Li, Y.N, Zhang, Y.Y, Zhong, X.Y, Zhou, Q. | 登録日 | 2020-12-31 | 公開日 | 2021-03-10 | 最終更新日 | 2022-06-29 | 実験手法 | ELECTRON MICROSCOPY (3.4 Å) | 主引用文献 | Mechanism of substrate transport and inhibition of the human LAT1-4F2hc amino acid transporter. Cell Discov, 7, 2021
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7DSN
| Overall structure of the LAT1-4F2hc bound with JX-119 | 分子名称: | (2~{S})-2-azanyl-7-[[2-(1,3-benzoxazol-2-yl)phenyl]methoxy]-3,4-dihydro-1~{H}-naphthalene-2-carboxylic acid, 1,2-DIACYL-GLYCEROL-3-SN-PHOSPHATE, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... | 著者 | Yan, R.H, Li, Y.N, Zhang, Y.Y, Zhong, X.Y, Zhou, Q. | 登録日 | 2020-12-31 | 公開日 | 2021-03-10 | 最終更新日 | 2022-06-29 | 実験手法 | ELECTRON MICROSCOPY (3.1 Å) | 主引用文献 | Mechanism of substrate transport and inhibition of the human LAT1-4F2hc amino acid transporter. Cell Discov, 7, 2021
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7DSK
| Overall structure of the LAT1-4F2hc bound with JX-075 | 分子名称: | (2~{S})-2-azanyl-7-(naphthalen-1-ylmethoxy)-3,4-dihydro-1~{H}-naphthalene-2-carboxylic acid, 1,2-DIACYL-GLYCEROL-3-SN-PHOSPHATE, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... | 著者 | Yan, R.H, Li, Y.N, Zhang, Y.Y, Zhong, X.Y, Zhou, Q. | 登録日 | 2020-12-31 | 公開日 | 2021-03-10 | 最終更新日 | 2022-06-29 | 実験手法 | ELECTRON MICROSCOPY (2.9 Å) | 主引用文献 | Mechanism of substrate transport and inhibition of the human LAT1-4F2hc amino acid transporter. Cell Discov, 7, 2021
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