4ZRK
| Merlin-FERM and Lats1 complex | 分子名称: | Merlin, Serine/threonine-protein kinase LATS1 | 著者 | Lin, Z, Li, Y, Wei, Z, Zhang, M. | 登録日 | 2015-05-12 | 公開日 | 2015-06-17 | 最終更新日 | 2023-11-08 | 実験手法 | X-RAY DIFFRACTION (2.316 Å) | 主引用文献 | Angiomotin binding-induced activation of Merlin/NF2 in the Hippo pathway Cell Res., 25, 2015
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6QLZ
| IDOL F3ab subdomain | 分子名称: | E3 ubiquitin-protein ligase MYLIP | 著者 | Martinelli, L, Johansson, P, Wan, P.T, Gunnarsson, J, Guo, H, Boyd, H. | 登録日 | 2019-02-01 | 公開日 | 2020-02-19 | 最終更新日 | 2024-01-24 | 実験手法 | X-RAY DIFFRACTION (2.343 Å) | 主引用文献 | Structural analysis of the LDL receptor-interacting FERM domain in the E3 ubiquitin ligase IDOL reveals an obscured substrate-binding site. J.Biol.Chem., 295, 2020
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8CIU
| The FERM domain of human moesin mutant H288A | 分子名称: | Moesin | 著者 | Bradshaw, W.J, Katis, V.L, Koekemoer, L, Bountra, C, von Delft, F, Brennan, P.E. | 登録日 | 2023-02-10 | 公開日 | 2023-03-01 | 最終更新日 | 2023-11-29 | 実験手法 | X-RAY DIFFRACTION (2.393 Å) | 主引用文献 | Discovery of FERM domain protein-protein interaction inhibitors for MSN and CD44 as a potential therapeutic approach for Alzheimer's disease. J.Biol.Chem., 299, 2023
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3X23
| Radixin complex | 分子名称: | Peptide from Matrix metalloproteinase-14, Radixin | 著者 | Terawaki, S, Kitano, K, Aoyama, M, Mori, T, Hakoshima, T. | 登録日 | 2014-12-09 | 公開日 | 2015-10-21 | 最終更新日 | 2023-11-08 | 実験手法 | X-RAY DIFFRACTION (2.396 Å) | 主引用文献 | MT1-MMP recognition by ERM proteins and its implication in CD44 shedding Genes Cells, 20, 2015
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1J19
| Crystal structure of the radxin FERM domain complexed with the ICAM-2 cytoplasmic peptide | 分子名称: | 16-mer peptide from Intercellular adhesion molecule-2, radixin | 著者 | Hamada, K, Shimizu, T, Yonemura, S, Tsukita, S, Tsukita, S, Hakoshima, T. | 登録日 | 2002-12-02 | 公開日 | 2003-03-11 | 最終更新日 | 2023-10-25 | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | 主引用文献 | Structural basis of adhesion-molecule recognition by ERM proteins revealed by the crystal structure of the radixin-ICAM-2 complex EMBO J., 22, 2003
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2D10
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6QLY
| IDOL FERM domain | 分子名称: | 1,2-ETHANEDIOL, E3 ubiquitin-protein ligase MYLIP, SULFATE ION | 著者 | Martinelli, L, Sixma, T.K. | 登録日 | 2019-02-01 | 公開日 | 2020-02-19 | 最終更新日 | 2024-01-24 | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | 主引用文献 | Structural analysis of the LDL receptor-interacting FERM domain in the E3 ubiquitin ligase IDOL reveals an obscured substrate-binding site. J.Biol.Chem., 295, 2020
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7EDR
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8CIT
| The FERM domain of human moesin mutant L281R | 分子名称: | Moesin | 著者 | Bradshaw, W.J, Katis, V.L, Koekemoer, L, Bountra, C, von Delft, F, Brennan, P.E. | 登録日 | 2023-02-10 | 公開日 | 2023-03-01 | 最終更新日 | 2023-11-29 | 実験手法 | X-RAY DIFFRACTION (2.536 Å) | 主引用文献 | Discovery of FERM domain protein-protein interaction inhibitors for MSN and CD44 as a potential therapeutic approach for Alzheimer's disease. J.Biol.Chem., 299, 2023
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4P7I
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6CDS
| Human neurofibromin 2/merlin/schwannomin residues 1-339 in complex with PIP2 | 分子名称: | DI(HYDROXYETHYL)ETHER, GLYCEROL, Merlin, ... | 著者 | Chinthalapudi, K, Sharff, A.J, Bricogne, G, Izard, T. | 登録日 | 2018-02-09 | 公開日 | 2018-07-18 | 最終更新日 | 2023-10-04 | 実験手法 | X-RAY DIFFRACTION (2.62 Å) | 主引用文献 | Lipid binding promotes the open conformation and tumor-suppressive activity of neurofibromin 2. Nat Commun, 9, 2018
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3U8Z
| human merlin FERM domain | 分子名称: | Merlin | 著者 | Yogesha, S.D, Sharff, A.J, Giovannini, M, Bricogne, G, Izard, T. | 登録日 | 2011-10-17 | 公開日 | 2011-11-02 | 最終更新日 | 2023-09-13 | 実験手法 | X-RAY DIFFRACTION (2.64 Å) | 主引用文献 | Unfurling of the band 4.1, ezrin, radixin, moesin (FERM) domain of the merlin tumor suppressor. Protein Sci., 20, 2011
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1E5W
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4ZRI
| Crystal structure of Merlin-FERM and Lats2 | 分子名称: | Merlin, Serine/threonine-protein kinase LATS2 | 著者 | Li, F, Zhou, H, Long, J, Shen, Y. | 登録日 | 2015-05-12 | 公開日 | 2015-06-17 | 最終更新日 | 2023-11-08 | 実験手法 | X-RAY DIFFRACTION (2.7 Å) | 主引用文献 | Angiomotin binding-induced activation of Merlin/NF2 in the Hippo pathway Cell Res., 25, 2015
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1GG3
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1GC7
| CRYSTAL STRUCTURE OF THE RADIXIN FERM DOMAIN | 分子名称: | RADIXIN | 著者 | Hamada, K, Shimizu, T, Matsui, T, Tsukita, S, Tsukita, S, Hakoshima, T. | 登録日 | 2000-07-21 | 公開日 | 2000-09-20 | 最終更新日 | 2023-12-27 | 実験手法 | X-RAY DIFFRACTION (2.8 Å) | 主引用文献 | Structural basis of the membrane-targeting and unmasking mechanisms of the radixin FERM domain. EMBO J., 19, 2000
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2D2Q
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2EMT
| Crystal Structure Analysis of the radixin FERM domain complexed with adhesion molecule PSGL-1 | 分子名称: | P-selectin glycoprotein ligand 1, Radixin | 著者 | Takai, Y, Kitano, K, Terawaki, S, Maesaki, R, Hakoshima, T. | 登録日 | 2007-03-28 | 公開日 | 2008-03-18 | 最終更新日 | 2023-10-25 | 実験手法 | X-RAY DIFFRACTION (2.8 Å) | 主引用文献 | Structural basis of PSGL-1 binding to ERM proteins Genes Cells, 12, 2007
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2D11
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1GC6
| CRYSTAL STRUCTURE OF THE RADIXIN FERM DOMAIN COMPLEXED WITH INOSITOL-(1,4,5)-TRIPHOSPHATE | 分子名称: | D-MYO-INOSITOL-1,4,5-TRIPHOSPHATE, RADIXIN | 著者 | Hamada, K, Shimizu, T, Matsui, T, Tsukita, S, Tsukita, S, Hakoshima, T. | 登録日 | 2000-07-21 | 公開日 | 2000-09-20 | 最終更新日 | 2023-12-27 | 実験手法 | X-RAY DIFFRACTION (2.9 Å) | 主引用文献 | Structural basis of the membrane-targeting and unmasking mechanisms of the radixin FERM domain. EMBO J., 19, 2000
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2EMS
| Crystal Structure Analysis of the radixin FERM domain complexed with adhesion molecule CD43 | 分子名称: | Leukosialin, Radixin | 著者 | Takai, Y, Kitano, K, Terawaki, S, Maesaki, R, Hakoshima, T. | 登録日 | 2007-03-28 | 公開日 | 2008-04-01 | 最終更新日 | 2023-10-25 | 実験手法 | X-RAY DIFFRACTION (2.9 Å) | 主引用文献 | Structural basis of the cytoplasmic tail of adhesion molecule CD43 and its binding to ERM proteins J.Mol.Biol., 381, 2008
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1ISN
| Crystal structure of merlin FERM domain | 分子名称: | merlin | 著者 | Shimizu, T, Seto, A, Maita, N, Hamada, K, Tsukita, S, Tsukita, S, Hakoshima, T. | 登録日 | 2001-12-13 | 公開日 | 2002-04-03 | 最終更新日 | 2023-10-25 | 実験手法 | X-RAY DIFFRACTION (2.9 Å) | 主引用文献 | Structural basis for neurofibromatosis type 2. Crystal structure of the merlin FERM domain. J.Biol.Chem., 277, 2002
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6D2Q
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2I1K
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8GXE
| PTPN21 FERM PTP complex | 分子名称: | CHLORIDE ION, Tyrosine-protein phosphatase non-receptor type 21 | 著者 | Chen, L, Zheng, Y.Y, Zhou, C. | 登録日 | 2022-09-19 | 公開日 | 2023-09-27 | 最終更新日 | 2024-04-17 | 実験手法 | X-RAY DIFFRACTION (3 Å) | 主引用文献 | Structural analysis of PTPN21 reveals a dominant-negative effect of the FERM domain on its phosphatase activity. Sci Adv, 10, 2024
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