3PRX
| Structure of Complement C5 in Complex with CVF and SSL7 | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Cobra venom factor, ... | 著者 | Laursen, N.S, Andersen, G.R, Sottrup-Jensen, L, Andersen, K.R, Spillner, E, Braren, I. | 登録日 | 2010-11-30 | 公開日 | 2011-01-19 | 最終更新日 | 2023-09-06 | 実験手法 | X-RAY DIFFRACTION (4.3 Å) | 主引用文献 | Substrate recognition by complement convertases revealed in the C5-cobra venom factor complex. Embo J., 30, 2011
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3PVM
| Structure of Complement C5 in Complex with CVF | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Cobra venom factor, Complement C5 | 著者 | Laursen, N.S, Andersen, K.R, Braren, I, Sottrup-Jensen, L, Spillner, E, Andersen, G.R. | 登録日 | 2010-12-07 | 公開日 | 2011-01-19 | 最終更新日 | 2023-09-06 | 実験手法 | X-RAY DIFFRACTION (4.3 Å) | 主引用文献 | Substrate recognition by complement convertases revealed in the C5-cobra venom factor complex. Embo J., 30, 2011
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3T4A
| Structure of a truncated form of Staphylococcal Complement Inhibitor B bound to human C3c at 3.4 Angstrom resolution | 分子名称: | Complement C3 beta chain, Complement C3c alpha' chain fragment 1, Complement C3c alpha' chain fragment 2, ... | 著者 | Garcia, B.L, Geisbrecht, B.V, Summers, B.J. | 登録日 | 2011-07-25 | 公開日 | 2011-11-23 | 最終更新日 | 2023-09-13 | 実験手法 | X-RAY DIFFRACTION (3.4 Å) | 主引用文献 | Diversity in the C3b Convertase Contact Residues and Tertiary Structures of the Staphylococcal Complement Inhibitor (SCIN) Protein Family. J.Biol.Chem., 287, 2012
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4A5W
| Crystal structure of C5b6 | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, COMPLEMENT C5, ... | 著者 | Hadders, M.A, Bubeck, D, Forneris, F, Pangburn, M, Llorca, O, Lea, S.M, Gros, P. | 登録日 | 2011-10-28 | 公開日 | 2012-03-14 | 最終更新日 | 2023-12-20 | 実験手法 | X-RAY DIFFRACTION (3.5 Å) | 主引用文献 | Assembly and Regulation of the Membrane Attack Complex Based on Structures of C5B6 and Sc5B9. Cell Rep., 1, 2012
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4D94
| Crystal Structure of TEP1r | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, CHLORIDE ION, ... | 著者 | Le, B.V, Williams, M, Logarajah, S, Baxter, R.H.G. | 登録日 | 2012-01-11 | 公開日 | 2012-10-17 | 最終更新日 | 2020-07-29 | 実験手法 | X-RAY DIFFRACTION (2.7 Å) | 主引用文献 | Molecular Basis for Genetic Resistance of Anopheles gambiae to Plasmodium: Structural Analysis of TEP1 Susceptible and Resistant Alleles. Plos Pathog., 8, 2012
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4E0S
| Crystal Structure of C5b-6 | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, Complement C5, ... | 著者 | Aleshin, A.E, Stec, B, DiScipio, R, Liddington, R.C. | 登録日 | 2012-03-05 | 公開日 | 2012-04-18 | 最終更新日 | 2023-09-13 | 実験手法 | X-RAY DIFFRACTION (4.21 Å) | 主引用文献 | Crystal structure of c5b-6 suggests structural basis for priming assembly of the membrane attack complex. J.Biol.Chem., 287, 2012
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4LNV
| Crystal Structure of TEP1s | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Thioester-containing protein I | 著者 | Le, B.V, Williams, M, Logarajah, S, Baxter, R.H.G. | 登録日 | 2013-07-12 | 公開日 | 2013-07-24 | 最終更新日 | 2023-09-20 | 実験手法 | X-RAY DIFFRACTION (3.7 Å) | 主引用文献 | Molecular basis for genetic resistance of Anopheles gambiae to Plasmodium: structural analysis of TEP1 susceptible and resistant alleles. Plos Pathog., 8, 2012
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5FO7
| Crystal Structure of Human Complement C3b at 2.8 Angstrom resolution | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, COMPLEMENT C3 BETA CHAIN, COMPLEMENT C3B ALPHA' CHAIN | 著者 | Forneris, F, Wu, J, Xue, X, Gros, P. | 登録日 | 2015-11-18 | 公開日 | 2016-04-06 | 最終更新日 | 2024-01-10 | 実験手法 | X-RAY DIFFRACTION (2.8 Å) | 主引用文献 | Regulators of Complement Activity Mediate Inhibitory Mechanisms Through a Common C3B-Binding Mode. Embo J., 35, 2016
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5FO8
| Crystal Structure of Human Complement C3b in Complex with MCP (CCP1-4) | 分子名称: | 1,2-ETHANEDIOL, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, COMPLEMENT C3, ... | 著者 | Forneris, F, Wu, J, Xue, X, Gros, P. | 登録日 | 2015-11-18 | 公開日 | 2016-04-06 | 最終更新日 | 2024-01-10 | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | 主引用文献 | Regulators of Complement Activity Mediate Inhibitory Mechanisms Through a Common C3B-Binding Mode. Embo J., 35, 2016
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5FO9
| Crystal Structure of Human Complement C3b in Complex with CR1 (CCP15- 17) | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, COMPLEMENT C3 BETA CHAIN, COMPLEMENT C3B ALPHA' CHAIN, ... | 著者 | Forneris, F, Wu, J, Xue, X, Gros, P. | 登録日 | 2015-11-18 | 公開日 | 2016-04-06 | 最終更新日 | 2024-01-10 | 実験手法 | X-RAY DIFFRACTION (3.3 Å) | 主引用文献 | Regulators of Complement Activity Mediate Inhibitory Mechanisms Through a Common C3B-Binding Mode. Embo J., 35, 2016
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5FOA
| Crystal Structure of Human Complement C3b in complex with DAF (CCP2-4) | 分子名称: | COMPLEMENT C3 BETA CHAIN, COMPLEMENT C3B ALPHA CHAIN, DECAY ACCELERATING FACTOR, ... | 著者 | Forneris, F, Wu, J, Xue, X, Gros, P. | 登録日 | 2015-11-18 | 公開日 | 2016-04-06 | 最終更新日 | 2024-01-10 | 実験手法 | X-RAY DIFFRACTION (4.188 Å) | 主引用文献 | Regulators of Complement Activity Mediate Inhibitory Mechanisms Through a Common C3B-Binding Mode. Embo J., 35, 2016
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5FOB
| Crystal Structure of Human Complement C3b in complex with Smallpox Inhibitor of Complement (SPICE) | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, CHLORIDE ION, COMPLEMENT C3 BETA CHAIN, ... | 著者 | Forneris, F, Wu, J, Xue, X, Gros, P. | 登録日 | 2015-11-18 | 公開日 | 2016-04-06 | 最終更新日 | 2024-01-10 | 実験手法 | X-RAY DIFFRACTION (2.6 Å) | 主引用文献 | Regulators of Complement Activity Mediate Inhibitory Mechanisms Through a Common C3B-Binding Mode. Embo J., 35, 2016
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5HCC
| Ternary complex of human Complement C5 with Ornithodoros moubata OmCI and Dermacentor andersoni RaCI3. | 分子名称: | 1,2-ETHANEDIOL, 1,4-DIETHYLENE DIOXIDE, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... | 著者 | Jore, M.M, Johnson, S, Lea, S.M. | 登録日 | 2016-01-04 | 公開日 | 2016-03-30 | 最終更新日 | 2024-01-10 | 実験手法 | X-RAY DIFFRACTION (2.59 Å) | 主引用文献 | Structural basis for therapeutic inhibition of complement C5. Nat.Struct.Mol.Biol., 23, 2016
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5HCD
| Ternary complex of human Complement C5 with Ornithodoros moubata OmCI and Rhipicephalus microplus RaCI2 | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, CYSTEINE, Complement C5, ... | 著者 | Jore, M.M, Johnson, S, Lea, S.M. | 登録日 | 2016-01-04 | 公開日 | 2016-03-30 | 最終更新日 | 2024-01-10 | 実験手法 | X-RAY DIFFRACTION (2.98 Å) | 主引用文献 | Structural basis for therapeutic inhibition of complement C5. Nat.Struct.Mol.Biol., 23, 2016
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5HCE
| Ternary complex of human Complement C5 with Ornithodoros moubata OmCI and Rhipicephalus appendiculatus RaCI1 | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, CYSTEINE, Complement C5, ... | 著者 | Jore, M.M, Johnson, S, Lea, S.M. | 登録日 | 2016-01-04 | 公開日 | 2016-03-30 | 最終更新日 | 2024-01-10 | 実験手法 | X-RAY DIFFRACTION (3.12 Å) | 主引用文献 | Structural basis for therapeutic inhibition of complement C5. Nat.Struct.Mol.Biol., 23, 2016
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5I5K
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5JPM
| Structure of the complex of human complement C4 with MASP-2 rebuilt using iMDFF | 分子名称: | Complement C4-A, Mannan-binding lectin serine protease 2, beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | 著者 | Croll, T.I, Andersen, G.R. | 登録日 | 2016-05-03 | 公開日 | 2016-08-10 | 最終更新日 | 2020-07-29 | 実験手法 | X-RAY DIFFRACTION (3.75 Å) | 主引用文献 | Re-evaluation of low-resolution crystal structures via interactive molecular-dynamics flexible fitting (iMDFF): a case study in complement C4. Acta Crystallogr D Struct Biol, 72, 2016
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5JPN
| Structure of human complement C4 rebuilt using iMDFF | 分子名称: | 2-acetamido-2-deoxy-alpha-D-galactopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Complement C4-A, ... | 著者 | Croll, T.I, Andersen, G.R. | 登録日 | 2016-05-03 | 公開日 | 2016-08-10 | 最終更新日 | 2020-07-29 | 実験手法 | X-RAY DIFFRACTION (3.6 Å) | 主引用文献 | Re-evaluation of low-resolution crystal structures via interactive molecular-dynamics flexible fitting (iMDFF): a case study in complement C4. Acta Crystallogr D Struct Biol, 72, 2016
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5JTW
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5O32
| The structure of complement complex | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, ... | 著者 | Xue, X, Wu, J, Forneris, F, Gros, P. | 登録日 | 2017-05-23 | 公開日 | 2017-06-28 | 最終更新日 | 2020-07-29 | 実験手法 | X-RAY DIFFRACTION (4.206209 Å) | 主引用文献 | Regulator-dependent mechanisms of C3b processing by factor I allow differentiation of immune responses. Nat. Struct. Mol. Biol., 24, 2017
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5O35
| Structure of complement proteins complex | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Complement C3, Complement factor H,Complement factor H | 著者 | Xue, X, Wu, J, Forneris, F, Gros, P. | 登録日 | 2017-05-23 | 公開日 | 2017-06-28 | 最終更新日 | 2020-07-29 | 実験手法 | X-RAY DIFFRACTION (4.2 Å) | 主引用文献 | Regulator-dependent mechanisms of C3b processing by factor I allow differentiation of immune responses. Nat. Struct. Mol. Biol., 24, 2017
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6EHG
| complement component C3b in complex with a nanobody | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Complement C3, beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... | 著者 | Jensen, R.K, Andersen, K.R, Gadeberg, T.A.F, Laursen, N.S, Andersen, G.R. | 登録日 | 2017-09-13 | 公開日 | 2018-02-14 | 最終更新日 | 2024-01-17 | 実験手法 | X-RAY DIFFRACTION (2.65 Å) | 主引用文献 | A potent complement factor C3-specific nanobody inhibiting multiple functions in the alternative pathway of human and murine complement. J. Biol. Chem., 293, 2018
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6H03
| OPEN CONFORMATION OF THE MEMBRANE ATTACK COMPLEX | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Complement C5,Complement C5, ... | 著者 | Menny, A, Serna, M, Boyd, C.M, Gardner, S, Joseph, A.P, Topf, M, Bubeck, D. | 登録日 | 2018-07-06 | 公開日 | 2018-12-19 | 最終更新日 | 2020-07-29 | 実験手法 | ELECTRON MICROSCOPY (5.6 Å) | 主引用文献 | CryoEM reveals how the complement membrane attack complex ruptures lipid bilayers. Nat Commun, 9, 2018
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6H04
| Closed conformation of the Membrane Attack Complex | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Complement C5,Complement C5, ... | 著者 | Menny, A, Serna, M, Boyd, C.M, Gardner, S, Joseph, A.P, Topf, M, Bubeck, D. | 登録日 | 2018-07-06 | 公開日 | 2018-12-19 | 最終更新日 | 2020-07-29 | 実験手法 | ELECTRON MICROSCOPY (5.6 Å) | 主引用文献 | CryoEM reveals how the complement membrane attack complex ruptures lipid bilayers. Nat Commun, 9, 2018
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6RQJ
| Structure of human complement C5 complexed with tick inhibitors OmCI, RaCI1 and CirpT1 | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Complement C5, Complement inhibitor, ... | 著者 | Reichhardt, M.P, Johnson, S, Lea, S.M. | 登録日 | 2019-05-15 | 公開日 | 2020-01-08 | 最終更新日 | 2020-07-29 | 実験手法 | ELECTRON MICROSCOPY (3.5 Å) | 主引用文献 | An inhibitor of complement C5 provides structural insights into activation. Proc.Natl.Acad.Sci.USA, 117, 2020
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