PDB: 35 resultsInfo pagesStatus searchChemie searchBIRD

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5V6Y	Crystal structure of the human CLR:RAMP1 extracellular domain heterodimer with bound high-affinity and altered selectivity adrenomedullin variant Descriptor: ADM, Maltose-binding periplasmic protein,Receptor activity-modifying protein 1,Calcitonin gene-related peptide type 1 receptor, alpha-D-glucopyranose-(1-4)-alpha-D-glucopyranose Authors: Pioszak, A, Booe, J. Deposit date: 2017-03-17 Release date: 2018-01-31 Last modified: 2023-10-04 Method: X-RAY DIFFRACTION (2.8 Å) Cite: Probing the Mechanism of Receptor Activity-Modifying Protein Modulation of GPCR Ligand Selectivity through Rational Design of Potent Adrenomedullin and Calcitonin Gene-Related Peptide Antagonists. Mol. Pharmacol., 93, 2018
4RWF	Crystal structure of the CLR:RAMP2 extracellular domain heterodimer with bound adrenomedullin Descriptor: 1,2-ETHANEDIOL, Adrenomedullin, Maltose transporter subunit, ... Authors: Booe, J, Pioszak, A. Deposit date: 2014-12-03 Release date: 2015-05-20 Last modified: 2020-07-29 Method: X-RAY DIFFRACTION (1.76 Å) Cite: Structural Basis for Receptor Activity-Modifying Protein-Dependent Selective Peptide Recognition by a G Protein-Coupled Receptor. Mol.Cell, 58, 2015
4RWG	Crystal structure of the CLR:RAMP1 extracellular domain heterodimer with bound high affinity CGRP analog Descriptor: CGRP analog, MAGNESIUM ION, Maltose-binding periplasmic protein, ... Authors: Booe, J, Pioszak, A. Deposit date: 2014-12-03 Release date: 2015-05-20 Last modified: 2023-09-20 Method: X-RAY DIFFRACTION (2.44 Å) Cite: Structural Basis for Receptor Activity-Modifying Protein-Dependent Selective Peptide Recognition by a G Protein-Coupled Receptor. Mol.Cell, 58, 2015
2XVT	Structure of the extracellular domain of human RAMP2 Descriptor: CALCIUM ION, RECEPTOR ACTIVITY-MODIFYING PROTEIN 2 Authors: Quigley, A, Pike, A.C.W, Burgess-Brown, N, Krojer, T, Shrestha, L, Goubin, S, Kim, J, Das, S, Muniz, J.R.C, Canning, P, Chaikuad, A, Vollmar, M, von Delft, F, Arrowsmith, C.H, Weigelt, J, Edwards, A.M, Bountra, C, Barr, A.J, Carpenter, E.P. Deposit date: 2010-10-31 Release date: 2010-12-29 Last modified: 2018-01-24 Method: X-RAY DIFFRACTION (2.05 Å) Cite: Structure of the Extracellular Domain of Human Ramp2 To be Published
3AQE	Crystal structure of the extracellular domain of human RAMP2 Descriptor: Receptor activity-modifying protein 2 Authors: Kusano, S, Kukimoto-Niino, M, Shirouzu, M, Shindo, T, Yokoyama, S. Deposit date: 2010-10-29 Release date: 2011-11-09 Last modified: 2012-07-25 Method: X-RAY DIFFRACTION (2 Å) Cite: Structural basis for extracellular interactions between calcitonin receptor-like receptor and receptor activity-modifying protein 2 for adrenomedullin-specific binding Protein Sci., 21, 2012
3AQF	Crystal structure of the human CRLR/RAMP2 extracellular complex Descriptor: Calcitonin gene-related peptide type 1 receptor, Receptor activity-modifying protein 2 Authors: Kusano, S, Kukimono-Niino, M, Shirouzu, M, Shindo, T, Yokoyama, S. Deposit date: 2010-10-29 Release date: 2011-11-02 Last modified: 2012-07-25 Method: X-RAY DIFFRACTION (2.6 Å) Cite: Structural basis for extracellular interactions between calcitonin receptor-like receptor and receptor activity-modifying protein 2 for adrenomedullin-specific binding Protein Sci., 21, 2012
3N7S	Crystal structure of the ectodomain complex of the CGRP receptor, a Class-B GPCR, reveals the site of drug antagonism Descriptor: Calcitonin gene-related peptide type 1 receptor, N-{(1S)-5-amino-1-[(4-pyridin-4-ylpiperazin-1-yl)carbonyl]pentyl}-3,5-dibromo-Nalpha-{[4-(2-oxo-1,4-dihydroquinazolin-3 (2H)-yl)piperidin-1-yl]carbonyl}-D-tyrosinamide, N~4~-(5-cyclopropyl-1H-pyrazol-3-yl)-N~2~-1H-indazol-5-yl-6-methylpyrimidine-2,4-diamine, ... Authors: Ter Haar, E. Deposit date: 2010-05-27 Release date: 2010-09-15 Last modified: 2022-10-26 Method: X-RAY DIFFRACTION (2.1 Å) Cite: Crystal Structure of the Ectodomain Complex of the CGRP Receptor, a Class-B GPCR, Reveals the Site of Drug Antagonism. Structure, 18, 2010
3N7P	Crystal structure of the ectodomain complex of the CGRP receptor, a Class-B GPCR, reveals the site of drug antagonism Descriptor: Calcitonin gene-related peptide type 1 receptor, Receptor activity-modifying protein 1, SULFATE ION Authors: Ter Haar, E. Deposit date: 2010-05-27 Release date: 2010-09-15 Last modified: 2017-11-08 Method: X-RAY DIFFRACTION (2.8 Å) Cite: Crystal Structure of the Ectodomain Complex of the CGRP Receptor, a Class-B GPCR, Reveals the Site of Drug Antagonism. Structure, 18, 2010
3N7R	Crystal structure of the ectodomain complex of the CGRP receptor, a Class-B GPCR, reveals the site of drug antagonism Descriptor: Calcitonin gene-related peptide type 1 receptor, N-[(3R,6S)-6-(2,3-difluorophenyl)-2-oxo-1-(2,2,2-trifluoroethyl)azepan-3-yl]-4-(2-oxo-2,3-dihydro-1H-imidazo[4,5-b]pyridin-1-yl)piperidine-1-carboxamide, N-{(1S)-5-amino-1-[(4-pyridin-4-ylpiperazin-1-yl)carbonyl]pentyl}-3,5-dibromo-Nalpha-{[4-(2-oxo-1,4-dihydroquinazolin-3 (2H)-yl)piperidin-1-yl]carbonyl}-D-tyrosinamide, ... Authors: Ter Haar, E. Deposit date: 2010-05-27 Release date: 2010-09-15 Last modified: 2022-10-26 Method: X-RAY DIFFRACTION (2.9 Å) Cite: Crystal Structure of the Ectodomain Complex of the CGRP Receptor, a Class-B GPCR, Reveals the Site of Drug Antagonism. Structure, 18, 2010
2YX8	Crystal structure of the extracellular domain of human RAMP1 Descriptor: Receptor activity-modifying protein 1 Authors: Kusano, S, Kukimoto-Niino, M, Shirouzu, M, Shindo, T, Yokoyama, S, RIKEN Structural Genomics/Proteomics Initiative (RSGI) Deposit date: 2007-04-24 Release date: 2008-04-29 Last modified: 2011-07-13 Method: X-RAY DIFFRACTION (2.4 Å) Cite: Crystal structure of the human receptor activity-modifying protein 1 extracellular domain. Protein Sci., 17, 2008

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