4RWF

Crystal structure of the CLR:RAMP2 extracellular domain heterodimer with bound adrenomedullin

Summary for 4RWF

Related4RWG
Related PRD IDPRD_900001
DescriptorMaltose transporter subunit, Receptor activity-modifying protein 2, Calcitonin gene-related peptide type 1 receptor fusion protein, Adrenomedullin, alpha-D-glucopyranose-(1-4)-alpha-D-glucopyranose, ... (5 entities in total)
Functional Keywordscell surface receptor, membrane protein-hormone complex, membrane protein/hormone
Biological sourceEscherichia coli (human)
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Cellular locationCell membrane; Multi-pass membrane protein Q16602
Secreted P35318
Total number of polymer chains2
Total molecular weight70213.65
Authors
Booe, J.,Pioszak, A. (deposition date: 2014-12-03, release date: 2015-05-20, Last modification date: 2020-07-29)
Primary citation
Booe, J.M.,Walker, C.S.,Barwell, J.,Kuteyi, G.,Simms, J.,Jamaluddin, M.A.,Warner, M.L.,Bill, R.M.,Harris, P.W.,Brimble, M.A.,Poyner, D.R.,Hay, D.L.,Pioszak, A.A.
Structural Basis for Receptor Activity-Modifying Protein-Dependent Selective Peptide Recognition by a G Protein-Coupled Receptor.
Mol.Cell, 58:1-13, 2015
PubMed: 25982113 (PDB entries with the same primary citation)
DOI: 10.1016/j.molcel.2015.04.018
MImport into Mendeley
Experimental method
X-RAY DIFFRACTION (1.76 Å)
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Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers 0.20630 1.7% 2.6%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution
Download full validation reportDownload
167518
PDB entries from 2020-08-12