4RWF
Crystal structure of the CLR:RAMP2 extracellular domain heterodimer with bound adrenomedullin
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A | Maltose transporter subunit, Receptor activity-modifying protein 2, Calcitonin gene-related peptide type 1 receptor fusion protein | polymer | 591 | 66308.4 | 1 | UniProt (P0AEX9) UniProt (O60895) UniProt (Q16602) Pfam (PF01547) Pfam (PF04901) Pfam (PF02793) In PDB | Escherichia coli (human) | |
2 | B | Adrenomedullin | polymer | 29 | 3252.7 | 1 | UniProt (P35318) In PDB | Homo sapiens | CGRP type 1 receptor, Calcitonin receptor-like receptor |
3 | C | alpha-D-glucopyranose-(1-4)-alpha-D-glucopyranose | branched | 342.3 | 1 | In PDB BIRD (PRD_900001) GlyTouCan (G07411ON) | alpha-maltose | ||
4 | A | 1,2-ETHANEDIOL | non-polymer | 62.1 | 5 | Chemie (EDO) | |||
5 | water | water | 18.0 | 394 | Chemie (HOH) |
Sequence modifications
A: 2 - 374 (UniProt: P0AEX9)
A: 1055 - 1138 (UniProt: O60895)
A: 2031 - 2116 (UniProt: Q16602)
B: 25 - 52 (UniProt: P35318)
PDB | External Database | Details |
---|---|---|
Met 1 | - | expression tag |
PDB | External Database | Details |
---|---|---|
Arg 1106 | Leu 106 | conflict |
Ser 1139 | - | linker |
PDB | External Database | Details |
---|---|---|
Asp 2019 | - | expression tag |
Gly 2020 | - | expression tag |
Ser 2021 | - | expression tag |
Ala 2022 | - | expression tag |
Gly 2023 | - | expression tag |
Ser 2024 | - | expression tag |
Ala 2025 | - | expression tag |
Gly 2026 | - | expression tag |
Ser 2027 | - | expression tag |
Ala 2028 | - | expression tag |
Glu 2029 | - | expression tag |
Asp 2030 | - | expression tag |
PDB | External Database | Details |
---|---|---|
Nh2 53 | - | amidation |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 2 |
Total formula weight | 69561.0 | |
Branched | Number of molecules | 1 |
Total formula weight | 342.3 | |
Non-Polymers* | Number of molecules | 5 |
Total formula weight | 310.3 | |
All* | Total formula weight | 70213.6 |