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8SUR	TMEM16F bound with Niclosamide Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 5-chloro-N-(2-chloro-4-nitrophenyl)-2-hydroxybenzamide, ... Authors: Feng, S, Cheng, Y. Deposit date: 2023-05-13 Release date: 2023-09-06 Last modified: 2023-11-01 Method: ELECTRON MICROSCOPY (3.1 Å) Cite: Identification of a drug binding pocket in TMEM16F calcium-activated ion channel and lipid scramblase. Nat Commun, 14, 2023
8TAG	TMEM16F, with Calcium and PIP2, no inhibitor Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, Anoctamin-6, CALCIUM ION Authors: Feng, S, Cheng, Y. Deposit date: 2023-06-27 Release date: 2023-09-06 Method: ELECTRON MICROSCOPY (3.2 Å) Cite: Identification of a drug binding pocket in TMEM16F calcium-activated ion channel and lipid scramblase. Nat Commun, 14, 2023
8TAI	TMEM16F, with Calcium and PIP2, no inhibitor, Cl2 Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, Anoctamin-6, CALCIUM ION Authors: Wu, H, Feng, S, Cheng, Y. Deposit date: 2023-06-27 Release date: 2023-09-06 Method: ELECTRON MICROSCOPY (3.1 Å) Cite: Identification of a drug binding pocket in TMEM16F calcium-activated ion channel and lipid scramblase. Nat Commun, 14, 2023
8TAL	TMEM16F, with Calcium and PIP2, no inhibitor, Cl1 Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, Anoctamin-6, CALCIUM ION Authors: Wu, H, Feng, S, Cheng, Y. Deposit date: 2023-06-27 Release date: 2023-09-06 Method: ELECTRON MICROSCOPY (3.2 Å) Cite: Identification of a drug binding pocket in TMEM16F calcium-activated ion channel and lipid scramblase. Nat Commun, 14, 2023
8TOI	nhTMEM16 lipid scramblase in lipid nanodiscs with MSP1E3 scaffold protein in the presence of Ca2+ (closed state) Descriptor: (1R)-2-{[(S)-{[(2S)-2,3-dihydroxypropyl]oxy}(hydroxy)phosphoryl]oxy}-1-[(hexadecanoyloxy)methyl]ethyl (9Z)-octadec-9-enoate, CALCIUM ION, Lipid scramblase nhTMEM16 Authors: Feng, Z, Accardi, A. Deposit date: 2023-08-03 Release date: 2024-05-08 Method: ELECTRON MICROSCOPY (2.64 Å) Cite: Structural basis of closed groove scrambling by a TMEM16 protein. Nat.Struct.Mol.Biol., 2024
8TOK	nhTMEM16 lipid scramblase in lipid nanodiscs with MSP2N2 scaffold protein in the presence of Ca2+ (open state) Descriptor: CALCIUM ION, Lipid scramblase nhTMEM16 Authors: Feng, Z, Accardi, A. Deposit date: 2023-08-03 Release date: 2024-05-08 Method: ELECTRON MICROSCOPY (3.84 Å) Cite: Structural basis of closed groove scrambling by a TMEM16 protein. Nat.Struct.Mol.Biol., 2024
8TOL	nhTMEM16 lipid scramblase in lipid nanodiscs with MSP1E3 scaffold protein in the presence of Ca2+ (open state) Descriptor: (1R)-2-{[(S)-{[(2S)-2,3-dihydroxypropyl]oxy}(hydroxy)phosphoryl]oxy}-1-[(hexadecanoyloxy)methyl]ethyl (9Z)-octadec-9-enoate, CALCIUM ION, Lipid scramblase nhTMEM16 Authors: Feng, Z, Accardi, A. Deposit date: 2023-08-03 Release date: 2024-05-08 Method: ELECTRON MICROSCOPY (2.85 Å) Cite: Structural basis of closed groove scrambling by a TMEM16 protein. Nat.Struct.Mol.Biol., 2024
8TPM	nhTMEM16 lipid scramblase in lipid nanodiscs with MSP1E3 scaffold protein in the absence of Ca2+ Descriptor: (1R)-2-{[(S)-{[(2S)-2,3-dihydroxypropyl]oxy}(hydroxy)phosphoryl]oxy}-1-[(hexadecanoyloxy)methyl]ethyl (9Z)-octadec-9-enoate, Lipid scramblase nhTMEM16 Authors: Feng, Z, Accardi, A. Deposit date: 2023-08-04 Release date: 2024-05-08 Method: ELECTRON MICROSCOPY (2.93 Å) Cite: Structural basis of closed groove scrambling by a TMEM16 protein. Nat.Struct.Mol.Biol., 2024
8TPN	nhTMEM16 lipid scramblase in lipid nanodiscs with MSP2N2 scaffold protein in the presence of Ca2+ (intermediate state) Descriptor: CALCIUM ION, Lipid scramblase nhTMEM16 Authors: Feng, Z, Accardi, A. Deposit date: 2023-08-04 Release date: 2024-05-08 Method: ELECTRON MICROSCOPY (4.07 Å) Cite: Structural basis of closed groove scrambling by a TMEM16 protein. Nat.Struct.Mol.Biol., 2024
8TPP	nhTMEM16 R432A mutant in lipid nanodiscs with MSP2N2 scaffold protein in the presence of Ca2+ Descriptor: CALCIUM ION, Lipid scramblase nhTMEM16 Authors: Feng, Z, Accardi, A. Deposit date: 2023-08-04 Release date: 2024-05-08 Method: ELECTRON MICROSCOPY (3.64 Å) Cite: Structural basis of closed groove scrambling by a TMEM16 protein. Nat.Struct.Mol.Biol., 2024
8TPQ	nhTMEM16 A444P mutant in lipid nanodiscs with MSP1E3 scaffold protein in the presence of Ca2+ (long TM6) Descriptor: (1R)-2-{[(S)-{[(2S)-2,3-dihydroxypropyl]oxy}(hydroxy)phosphoryl]oxy}-1-[(hexadecanoyloxy)methyl]ethyl (9Z)-octadec-9-enoate, CALCIUM ION, Lipid scramblase nhTMEM16 Authors: Feng, Z, Accardi, A. Deposit date: 2023-08-04 Release date: 2024-05-08 Method: ELECTRON MICROSCOPY (3.35 Å) Cite: Structural basis of closed groove scrambling by a TMEM16 protein. Nat.Struct.Mol.Biol., 2024
8TPR	nhTMEM16 A444P mutant in lipid nanodiscs with MSP1E3 scaffold protein in the presence of Ca2+ (short TM6) Descriptor: (1R)-2-{[(S)-{[(2S)-2,3-dihydroxypropyl]oxy}(hydroxy)phosphoryl]oxy}-1-[(hexadecanoyloxy)methyl]ethyl (9Z)-octadec-9-enoate, CALCIUM ION, Lipid scramblase nhTMEM16 Authors: Feng, Z, Accardi, A. Deposit date: 2023-08-04 Release date: 2024-05-08 Method: ELECTRON MICROSCOPY (2.85 Å) Cite: Structural basis of closed groove scrambling by a TMEM16 protein. Nat.Struct.Mol.Biol., 2024
8TPS	nhTMEM16 A444P mutant in lipid nanodiscs with MSP1E3 scaffold protein in the presence of Ca2+ (bent TM6) Descriptor: (1R)-2-{[(S)-{[(2S)-2,3-dihydroxypropyl]oxy}(hydroxy)phosphoryl]oxy}-1-[(hexadecanoyloxy)methyl]ethyl (9Z)-octadec-9-enoate, CALCIUM ION, Lipid scramblase nhTMEM16 Authors: Feng, Z, Accardi, A. Deposit date: 2023-08-04 Release date: 2024-05-08 Method: ELECTRON MICROSCOPY (2.97 Å) Cite: Structural basis of closed groove scrambling by a TMEM16 protein. Nat.Struct.Mol.Biol., 2024
8TPT	nhTMEM16 A444P mutant in lipid nanodiscs with MSP1E3 scaffold protein in the presence of Ca2+ (long TM6/short TM6) Descriptor: (1R)-2-{[(S)-{[(2S)-2,3-dihydroxypropyl]oxy}(hydroxy)phosphoryl]oxy}-1-[(hexadecanoyloxy)methyl]ethyl (9Z)-octadec-9-enoate, CALCIUM ION, Lipid scramblase nhTMEM16 Authors: Feng, Z, Accardi, A. Deposit date: 2023-08-04 Release date: 2024-05-08 Method: ELECTRON MICROSCOPY (3.01 Å) Cite: Structural basis of closed groove scrambling by a TMEM16 protein. Nat.Struct.Mol.Biol., 2024

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