8TPS

nhTMEM16 A444P mutant in lipid nanodiscs with MSP1E3 scaffold protein in the presence of Ca2+ (bent TM6)

Summary for 8TPS

• Entry DOI: 10.2210/pdb8tps/pdb
• EMDB information: 41483
• Descriptor: Lipid scramblase nhTMEM16, CALCIUM ION, (1R)-2-{[(S)-{[(2S)-2,3-dihydroxypropyl]oxy}(hydroxy)phosphoryl]oxy}-1-[(hexadecanoyloxy)methyl]ethyl (9Z)-octadec-9-enoate (3 entities in total)
• Functional Keywords: membrane protein, lipid scramblase, tmem16, lipid transport
• Biological source: Fusarium vanettenii 77-13-4
• Total number of polymer chains: 2
• Total formula weight: 169716.37

Authors

Feng, Z.,Accardi, A. (deposition date: 2023-08-04, release date: 2024-05-08)

• Primary citation: Feng, Z.,Alvarenga, O.E.,Accardi, A.; Structural basis of closed groove scrambling by a TMEM16 protein.; Nat.Struct.Mol.Biol., 2024; PubMed: 38684930; DOI: 10.1038/s41594-024-01284-9

Experimental method

ELECTRON MICROSCOPY (2.97 Å)