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4JLQ	Crystal structure of human Karyopherin-beta2 bound to the PY-NLS of Saccharomyces cerevisiae NAB2 Descriptor: Nuclear polyadenylated RNA-binding protein NAB2, Transportin-1 Authors: Sampathkumar, P, Gizzi, A, Rout, M.P, Chook, Y.M, Almo, S.C, New York Structural Genomics Research Consortium (NYSGRC), Nucleocytoplasmic Transport: a Target for Cellular Control (NPCXstals) Deposit date: 2013-03-12 Release date: 2013-04-03 Last modified: 2023-09-20 Method: X-RAY DIFFRACTION (3.05 Å) Cite: Crystal structure of human Karyopherin beta 2 bound to the PY-NLS of Saccharomyces cerevisiae Nab2. J.Struct.Funct.Genom., 14, 2013
4HAW	Crystal structure of CRM1 inhibitor Leptomycin B in complex with CRM1(K548A)-Ran-RanBP1 Descriptor: 1,2-ETHANEDIOL, CHLORIDE ION, Exportin-1, ... Authors: Sun, Q, Chook, Y.M. Deposit date: 2012-09-27 Release date: 2013-01-09 Last modified: 2017-07-26 Method: X-RAY DIFFRACTION (1.9 Å) Cite: Nuclear export inhibition through covalent conjugation and hydrolysis of Leptomycin B by CRM1. Proc.Natl.Acad.Sci.USA, 110, 2013
4HB4	Crystal structure of CRM1 inhibitor Leptomycin B in complex with CRM1(537DLTVK541/GLCEQ)-Ran-RanBP1 Descriptor: 1,2-ETHANEDIOL, CHLORIDE ION, Exportin-1, ... Authors: Sun, Q, Chook, Y.M. Deposit date: 2012-09-27 Release date: 2013-01-09 Last modified: 2017-07-26 Method: X-RAY DIFFRACTION (2.05 Å) Cite: Nuclear export inhibition through covalent conjugation and hydrolysis of Leptomycin B by CRM1. Proc.Natl.Acad.Sci.USA, 110, 2013
4HAZ	Crystal structure of CRM1 inhibitor Leptomycin B in complex with CRM1(R543S,K548E,K579Q)-Ran-RanBP1 Descriptor: CHLORIDE ION, Exportin-1, GTP-binding nuclear protein Ran, ... Authors: Sun, Q, Chook, Y.M. Deposit date: 2012-09-27 Release date: 2013-01-09 Last modified: 2017-07-26 Method: X-RAY DIFFRACTION (1.9 Å) Cite: Nuclear export inhibition through covalent conjugation and hydrolysis of Leptomycin B by CRM1. Proc.Natl.Acad.Sci.USA, 110, 2013
4HAY	Crystal structure of CRM1 inhibitor Leptomycin B in complex with CRM1(K548E,K579Q)-Ran-RanBP1 Descriptor: 1,2-ETHANEDIOL, CHLORIDE ION, Exportin-1, ... Authors: Sun, Q, Chook, Y.M. Deposit date: 2012-09-27 Release date: 2013-01-09 Last modified: 2017-07-26 Method: X-RAY DIFFRACTION (2.3 Å) Cite: Nuclear export inhibition through covalent conjugation and hydrolysis of Leptomycin B by CRM1. Proc.Natl.Acad.Sci.USA, 110, 2013
4HB3	Crystal structure of CRM1(T539S)-Ran-RanBP1 with weakly bound unmodeled Leptomycin B Descriptor: CHLORIDE ION, Exportin-1, GTP-binding nuclear protein Ran, ... Authors: Sun, Q, Chook, Y.M. Deposit date: 2012-09-27 Release date: 2013-01-09 Last modified: 2024-02-28 Method: X-RAY DIFFRACTION (2.8 Å) Cite: Nuclear export inhibition through covalent conjugation and hydrolysis of Leptomycin B by CRM1. Proc.Natl.Acad.Sci.USA, 110, 2013
4HAT	Crystal structure of CRM1 inhibitor Leptomycin B in complex with CRM1-Ran-RanBP1 Descriptor: 1,2-ETHANEDIOL, CHLORIDE ION, Exportin-1, ... Authors: Sun, Q, Chook, Y.M. Deposit date: 2012-09-27 Release date: 2013-01-09 Last modified: 2017-07-26 Method: X-RAY DIFFRACTION (1.78 Å) Cite: Nuclear export inhibition through covalent conjugation and hydrolysis of Leptomycin B by CRM1. Proc.Natl.Acad.Sci.USA, 110, 2013
4HB0	Crystal structure of CRM1 inhibitor Leptomycin B in complex with CRM1(K541Q,K542Q,R543S,K545Q,K548Q,K579Q)-Ran-RanBP1 Descriptor: CHLORIDE ION, Exportin-1, GTP-binding nuclear protein Ran, ... Authors: Sun, Q, Chook, Y.M. Deposit date: 2012-09-27 Release date: 2013-01-09 Last modified: 2017-07-26 Method: X-RAY DIFFRACTION (2.2 Å) Cite: Nuclear export inhibition through covalent conjugation and hydrolysis of Leptomycin B by CRM1. Proc.Natl.Acad.Sci.USA, 110, 2013
4HAX	Crystal structure of CRM1 inhibitor Ratjadone A in complex with CRM1(K579A)-Ran-RanBP1 Descriptor: 1,2-ETHANEDIOL, CHLORIDE ION, Exportin-1, ... Authors: Sun, Q, Chook, Y.M. Deposit date: 2012-09-27 Release date: 2013-01-09 Last modified: 2017-07-26 Method: X-RAY DIFFRACTION (2.28 Å) Cite: Nuclear export inhibition through covalent conjugation and hydrolysis of Leptomycin B by CRM1. Proc.Natl.Acad.Sci.USA, 110, 2013
4HAV	Crystal structure of CRM1 inhibitor Anguinomycin A in complex with CRM1-Ran-RanBP1 Descriptor: Anguinomycin A, bound form, CHLORIDE ION, ... Authors: Sun, Q, Chook, Y.M. Deposit date: 2012-09-27 Release date: 2013-01-09 Last modified: 2017-07-26 Method: X-RAY DIFFRACTION (2 Å) Cite: Nuclear export inhibition through covalent conjugation and hydrolysis of Leptomycin B by CRM1. Proc.Natl.Acad.Sci.USA, 110, 2013
4HB2	Crystal structure of CRM1-Ran-RanBP1 Descriptor: 1,2-ETHANEDIOL, CHLORIDE ION, Exportin-1, ... Authors: Sun, Q, Chook, Y.M. Deposit date: 2012-09-27 Release date: 2013-01-09 Last modified: 2024-02-28 Method: X-RAY DIFFRACTION (1.8 Å) Cite: Nuclear export inhibition through covalent conjugation and hydrolysis of Leptomycin B by CRM1. Proc.Natl.Acad.Sci.USA, 110, 2013
4HAU	Crystal structure of CRM1 inhibitor Ratjadone A in complex with CRM1-Ran-RanBP1 Descriptor: 1,2-ETHANEDIOL, CHLORIDE ION, Exportin-1, ... Authors: Sun, Q, Chook, Y.M. Deposit date: 2012-09-27 Release date: 2013-01-09 Last modified: 2017-07-26 Method: X-RAY DIFFRACTION (2 Å) Cite: Nuclear export inhibition through covalent conjugation and hydrolysis of Leptomycin B by CRM1. Proc.Natl.Acad.Sci.USA, 110, 2013
3VYC	Crystal structure of unliganded Saccharomyces cerevisiae CRM1 (Xpo1p) Descriptor: Exportin-1 Authors: Saito, N, Matsuura, Y. Deposit date: 2012-09-22 Release date: 2012-11-28 Last modified: 2024-03-20 Method: X-RAY DIFFRACTION (2.1 Å) Cite: A 2.1- angstrom -resolution crystal structure of unliganded CRM1 reveals the mechanism of autoinhibition J.Mol.Biol., 425, 2013
4GMX	Crystal structure of KPT185 in complex with CRM1-Ran-RanBP1 Descriptor: 1,2-ETHANEDIOL, CHLORIDE ION, Exportin-1, ... Authors: Sun, Q, Chook, Y.M. Deposit date: 2012-08-16 Release date: 2012-10-17 Last modified: 2012-12-12 Method: X-RAY DIFFRACTION (2.1 Å) Cite: Selective inhibitors of nuclear export show that CRM1/XPO1 is a target in chronic lymphocytic leukemia. Blood, 120, 2012
4GPT	Crystal structure of KPT251 in complex with CRM1-Ran-RanBP1 Descriptor: 1,2-ETHANEDIOL, 2-(2-{3-[3,5-bis(trifluoromethyl)phenyl]-1H-1,2,4-triazol-1-yl}ethyl)-1,3,4-oxadiazole, CHLORIDE ION, ... Authors: Sun, Q, Chook, Y.M. Deposit date: 2012-08-21 Release date: 2012-09-05 Last modified: 2013-01-23 Method: X-RAY DIFFRACTION (2.22 Å) Cite: Antileukemic activity of nuclear export inhibitors that spare normal hematopoietic cells. Leukemia, 27, 2013
4FDD	Crystal structure of KAP beta2-PY-NLS Descriptor: RNA-binding protein FUS, Transportin-1 Authors: Zhang, Z.C, Chook, Y.M. Deposit date: 2012-05-28 Release date: 2012-07-18 Last modified: 2024-02-28 Method: X-RAY DIFFRACTION (2.3 Å) Cite: Structural and energetic basis of ALS-causing mutations in the atypical proline-tyrosine nuclear localization signal of the Fused in Sarcoma protein (FUS). Proc.Natl.Acad.Sci.USA, 109, 2012
2XWU	CRYSTAL STRUCTURE OF IMPORTIN 13 - UBC9 COMPLEX Descriptor: IMPORTIN13, SUMO-CONJUGATING ENZYME UBC9 Authors: Gruenwald, M, Bono, F. Deposit date: 2010-11-05 Release date: 2010-12-29 Last modified: 2023-12-20 Method: X-RAY DIFFRACTION (2.8 Å) Cite: Structure of Importin13-Ubc9 Complex: Nuclear Import and Release of a Key Regulator of Sumoylation. Embo J., 30, 2011
3NC0	Crystal structure of the HIV-1 Rev NES-CRM1-RanGTP nuclear export complex (crystal II) Descriptor: DI(HYDROXYETHYL)ETHER, Exportin-1, GLYCEROL, ... Authors: Guttler, T, Madl, T, Neumann, P, Deichsel, D, Corsini, L, Monecke, T, Ficner, R, Sattler, M, Gorlich, D. Deposit date: 2010-06-04 Release date: 2010-10-27 Last modified: 2023-09-06 Method: X-RAY DIFFRACTION (2.9 Å) Cite: NES consensus redefined by structures of PKI-type and Rev-type nuclear export signals bound to CRM1. Nat.Struct.Mol.Biol., 17, 2010
3NBY	Crystal structure of the PKI NES-CRM1-RanGTP nuclear export complex Descriptor: Exportin-1, GTP-binding nuclear protein Ran, GUANOSINE-5'-TRIPHOSPHATE, ... Authors: Guttler, T, Madl, T, Neumann, P, Deichsel, D, Corsini, L, Monecke, T, Ficner, R, Sattler, M, Gorlich, D. Deposit date: 2010-06-04 Release date: 2010-10-27 Last modified: 2023-09-06 Method: X-RAY DIFFRACTION (3.42 Å) Cite: NES consensus redefined by structures of PKI-type and Rev-type nuclear export signals bound to CRM1. Nat.Struct.Mol.Biol., 17, 2010
3NBZ	Crystal structure of the HIV-1 Rev NES-CRM1-RanGTP nuclear export complex (crystal I) Descriptor: Exportin-1, GTP-binding nuclear protein Ran, GUANOSINE-5'-TRIPHOSPHATE, ... Authors: Guttler, T, Madl, T, Neumann, P, Deichsel, D, Corsini, L, Monecke, T, Ficner, R, Sattler, M, Gorlich, D. Deposit date: 2010-06-04 Release date: 2010-10-27 Last modified: 2023-09-06 Method: X-RAY DIFFRACTION (2.8 Å) Cite: NES consensus redefined by structures of PKI-type and Rev-type nuclear export signals bound to CRM1. Nat.Struct.Mol.Biol., 17, 2010
3NC1	Crystal structure of the CRM1-RanGTP complex Descriptor: Exportin-1, GTP-binding nuclear protein Ran, GUANOSINE-5'-TRIPHOSPHATE, ... Authors: Guttler, T, Madl, T, Neumann, P, Deichsel, D, Corsini, L, Monecke, T, Ficner, R, Sattler, M, Gorlich, D. Deposit date: 2010-06-04 Release date: 2010-10-27 Last modified: 2023-09-06 Method: X-RAY DIFFRACTION (3.35 Å) Cite: NES consensus redefined by structures of PKI-type and Rev-type nuclear export signals bound to CRM1. Nat.Struct.Mol.Biol., 17, 2010
3ND2	Structure of Yeast Importin-beta (Kap95p) Descriptor: Importin subunit beta-1 Authors: Forwood, J.K, Kobe, B. Deposit date: 2010-06-06 Release date: 2010-07-07 Last modified: 2023-11-01 Method: X-RAY DIFFRACTION (2.4 Å) Cite: Quantitative Structural Analysis of Importin-beta Flexibility: Paradigm for Solenoid Protein Structures Structure, 18, 2010
3LWW	Structure of an open and closed conformation of Human Importin Beta bound to the Snurportin1 IBB-domain trapped in the same crystallographic asymmetric unit Descriptor: Importin subunit beta-1, Snurportin-1 Authors: Bhardwaj, A, Cingolani, G. Deposit date: 2010-02-24 Release date: 2010-06-02 Last modified: 2023-09-06 Method: X-RAY DIFFRACTION (3.15 Å) Cite: Conformational selection in the recognition of the snurportin importin beta binding domain by importin beta. Biochemistry, 49, 2010
3M1I	Crystal structure of yeast CRM1 (Xpo1p) in complex with yeast RanBP1 (Yrb1p) and yeast RanGTP (Gsp1pGTP) Descriptor: Exportin-1, GTP-binding nuclear protein GSP1/CNR1, GUANOSINE-5'-TRIPHOSPHATE, ... Authors: Koyama, M, Matsuura, Y. Deposit date: 2010-03-05 Release date: 2010-06-02 Last modified: 2023-11-01 Method: X-RAY DIFFRACTION (2 Å) Cite: An allosteric mechanism to displace nuclear export cargo from CRM1 and RanGTP by RanBP1 Embo J., 29, 2010
2X1G	Crystal structure of Importin13 - Mago-Y14 complex Descriptor: CADMUS, PROTEIN MAGO NASHI, RNA-BINDING PROTEIN 8A Authors: Bono, F, Cook, A.G, Gruenwald, M, Ebert, J, Conti, E. Deposit date: 2009-12-23 Release date: 2010-02-16 Last modified: 2023-12-20 Method: X-RAY DIFFRACTION (3.35 Å) Cite: Nuclear Import Mechanism of the Ejc Component Mago- Y14 Revealed by Structural Studies of Importin 13. Mol.Cell, 37, 2010

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