PDB: 174 件ウェブページステータス検索Chemie searchBIRD

---

4DKI	Structural Insights into the Anti- Methicillin-Resistant Staphylococcus aureus (MRSA) Activity of Ceftobiprole 分子名称: (2R)-2-[(1R)-1-{[(2Z)-2-(5-amino-1,2,4-thiadiazol-3-yl)-2-(hydroxyimino)acetyl]amino}-2-oxoethyl]-5-({2-oxo-1-[(3R)-pyrrolidin-3-yl]-2,5-dihydro-1H-pyrrol-3-yl}methyl)-3,6-dihydro-2H-1,3-thiazine-4-carboxylic acid, BICARBONATE ION, CADMIUM ION, ... 著者 Lovering, A.L, Gretes, M.C, Strynadka, N.C.J. 登録日 2012-02-03 公開日 2012-08-01 最終更新日 2012-10-03 実験手法 X-RAY DIFFRACTION (2.9 Å) 主引用文献 Structural Insights into the Anti-methicillin-resistant Staphylococcus aureus (MRSA) Activity of Ceftobiprole. J.Biol.Chem., 287, 2012
6TIX	Crystal structure of penicillin-binding protein 2 from Yersinia pestis in complex with mecillinam 分子名称: 2-[(1R)-1-{[(E)-azepan-1-ylmethylidene]amino}-2-oxoethyl]-5,5-dimethyl-1,3-thiazolidine-4-carboxylic acid, Peptidoglycan D,D-transpeptidase MrdA 著者 Pankov, G, Hunter, W.N, Dawson, A. 登録日 2019-11-22 公開日 2020-12-02 最終更新日 2024-01-24 実験手法 X-RAY DIFFRACTION (2.8 Å) 主引用文献 The structure of penicillin-binding protein 2 from Yersinia pestis in complex with mecillinam To Be Published
6G88	Crystal structure of Enterococcus Faecium D63r Penicillin-Binding protein 5 (PBP5fm) 分子名称: (2R)-2-[(1R)-1-{[(2Z)-2-(5-amino-1,2,4-thiadiazol-3-yl)-2-(hydroxyimino)acetyl]amino}-2-oxoethyl]-5-({2-oxo-1-[(3R)-pyrrolidin-3-yl]-2,5-dihydro-1H-pyrrol-3-yl}methyl)-3,6-dihydro-2H-1,3-thiazine-4-carboxylic acid, Low affinity penicillin-binding protein 5 (PBP5), SULFATE ION 著者 Sauvage, E, El Gachi, M, Herman, R, Kerff, F, Charlier, P. 登録日 2018-04-08 公開日 2019-04-24 実験手法 X-RAY DIFFRACTION (3.3 Å) 主引用文献 Structural basis of inactivation of Enterococcus faecium penicillin binding protein 5 by ceftobiprole. To Be Published
4CJN	Crystal structure of PBP2a from MRSA in complex with quinazolinone ligand 分子名称: (E)-3-(2-(4-cyanostyryl)-4-oxoquinazolin-3(4H)-yl)benzoic acid, CADMIUM ION, CHLORIDE ION, ... 著者 Bouley, R, Otero, L.H, Rojas-Altuve, A, Hermoso, J.A. 登録日 2013-12-21 公開日 2015-02-11 最終更新日 2023-12-20 実験手法 X-RAY DIFFRACTION (1.947 Å) 主引用文献 Discovery of Antibiotic (E)-3-(3-Carboxyphenyl)-2-(4-Cyanostyryl)Quinazolin-4(3H)-One. J.Am.Chem.Soc., 137, 2015
6TII	Crystal structure of penicillin-binding protein 2 from Yersinia pestis 分子名称: BROMIDE ION, Peptidoglycan D,D-transpeptidase MrdA 著者 Pankov, G, Hunter, W.N, Dawson, A. 登録日 2019-11-22 公開日 2020-12-02 最終更新日 2024-01-24 実験手法 X-RAY DIFFRACTION (2.26 Å) 主引用文献 The structure of penicillin-binding protein 2 from Yersinia pestis To Be Published
6HR9	Nitrocefin acylation of both catalytic serines of the Y409 mutant of penicillin-binding protein 3 from P. aeruginosa 分子名称: Nitrocefin - open form, Peptidoglycan D,D-transpeptidase FtsI 著者 Bellini, D, Dowson, C.G. 登録日 2018-09-26 公開日 2019-10-23 最終更新日 2024-01-24 実験手法 X-RAY DIFFRACTION (1.99 Å) 主引用文献 Nitrocefin acylation of both catalytic serines of penicillin-binding protein 3 from P. aeruginosa To Be Published
6HZR	Apo structure of Pseudomonas aeruginosa Penicillin-Binding Protein 3 分子名称: Peptidoglycan D,D-transpeptidase FtsI 著者 Bellini, D, Dowson, C.G. 登録日 2018-10-23 公開日 2019-11-20 最終更新日 2024-01-24 実験手法 X-RAY DIFFRACTION (1.19 Å) 主引用文献 Novel and Improved Crystal Structures of H. influenzae, E. coli and P. aeruginosa Penicillin-Binding Protein 3 (PBP3) and N. gonorrhoeae PBP2: Toward a Better Understanding of beta-Lactam Target-Mediated Resistance. J.Mol.Biol., 431, 2019
6TUD	Crystal structure of Y. pestis penicillin-binding protein 3 分子名称: Peptidoglycan D,D-transpeptidase FtsI 著者 Pankov, G, Hunter, W.N, Dawson, A. 登録日 2020-01-06 公開日 2021-01-27 最終更新日 2024-01-24 実験手法 X-RAY DIFFRACTION (3 Å) 主引用文献 The structure of penicillin-binding protein 3 from Yersinia pestis To Be Published
6HR6	Nitrocefin reacted with catalytic serine (Ser294) of penicillin-binding protein 3 from Pseudomonas aeruginosa 分子名称: Nitrocefin - open form, Peptidoglycan D,D-transpeptidase FtsI 著者 Bellini, D, Dowson, C.G. 登録日 2018-09-26 公開日 2019-10-23 最終更新日 2024-01-24 実験手法 X-RAY DIFFRACTION (2.53 Å) 主引用文献 Nitrocefin acylation of single catalytic serine of penicillin-binding protein 3 from P. aeruginosa To Be Published
6HR4	Apo form of penicillin-binding protein 3 from P. aeruginosa 分子名称: Peptidoglycan D,D-transpeptidase FtsI 著者 Bellini, D, Dowson, C.G. 登録日 2018-09-26 公開日 2019-10-23 最終更新日 2024-01-24 実験手法 X-RAY DIFFRACTION (1.19 Å) 主引用文献 Apo form of penicillin-binding protein 3 from P. aeruginosa To Be Published
1MWT	Structure of penicillin G acyl-Penicillin binding protein 2a from methicillin resistant Staphylococcus aureus strain 27r at 2.45 A resolution. 分子名称: CADMIUM ION, CHLORIDE ION, OPEN FORM - PENICILLIN G, ... 著者 Lim, D.C, Strynadka, N.C.J. 登録日 2002-10-01 公開日 2002-11-06 最終更新日 2018-10-24 実験手法 X-RAY DIFFRACTION (2.45 Å) 主引用文献 Structural basis for the beta lactam resistance of PBP2a from methicillin-resistant Staphylococcus aureus. Nat.Struct.Biol., 9, 2002
5KSH	Crystal structure of penicillin-binding protein 2 from Neisseria gonorrhoeae containing an A501T mutation associated with cephalosporin resistance 分子名称: GLYCEROL, Penicillin-binding protein 2, SULFATE ION 著者 Fedarovich, A, Davies, C. 登録日 2016-07-08 公開日 2017-03-01 最終更新日 2023-10-04 実験手法 X-RAY DIFFRACTION (2.4 Å) 主引用文献 Alanine 501 Mutations in Penicillin-Binding Protein 2 from Neisseria gonorrhoeae: Structure, Mechanism, and Effects on Cephalosporin Resistance and Biological Fitness. Biochemistry, 56, 2017
3PBR	Crystal structure of PBP3 complexed with meropenem 分子名称: (4R,5S)-3-{[(3S,5S)-5-(dimethylcarbamoyl)pyrrolidin-3-yl]sulfanyl}-5-[(2S,3R)-3-hydroxy-1-oxobutan-2-yl]-4-methyl-4,5-dihydro-1H-pyrrole-2-carboxylic acid, Penicillin-binding protein 3 著者 Han, S. 登録日 2010-10-20 公開日 2010-12-22 最終更新日 2012-05-16 実験手法 X-RAY DIFFRACTION (1.95 Å) 主引用文献 Structural basis for effectiveness of siderophore-conjugated monocarbams against clinically relevant strains of Pseudomonas aeruginosa. Proc.Natl.Acad.Sci.USA, 107, 2010
1MWR	Structure of SeMet Penicillin binding protein 2a from methicillin resistant Staphylococcus aureus strain 27r (trigonal form) at 2.45 A resolution. 分子名称: CADMIUM ION, CHLORIDE ION, penicillin-binding protein 2a 著者 Lim, D.C, Strynadka, N.C.J. 登録日 2002-10-01 公開日 2002-11-06 最終更新日 2011-07-13 実験手法 X-RAY DIFFRACTION (2.45 Å) 主引用文献 Structural basis for the beta lactam resistance of PBP2a from methicillin-resistant Staphylococcus aureus. Nat.Struct.Biol., 9, 2002
1MWS	Structure of nitrocefin acyl-Penicillin binding protein 2a from methicillin resistant Staphylococcus aureus strain 27r at 2.00 A resolution. 分子名称: CADMIUM ION, CHLORIDE ION, penicillin-binding protein 2a 著者 Lim, D.C, Strynadka, N.C.J. 登録日 2002-10-01 公開日 2002-11-06 最終更新日 2011-07-13 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 Structural basis for the beta lactam resistance of PBP2a from methicillin-resistant Staphylococcus aureus. Nat.Struct.Biol., 9, 2002
3VSK	Crystal structure of penicillin-binding protein 3 (PBP3) from methicilin-resistant Staphylococcus aureus in the apo form. 分子名称: Penicillin-binding protein 3 著者 Yoshida, H, Tame, J.R, Park, S.Y. 登録日 2012-04-25 公開日 2012-10-31 最終更新日 2024-03-20 実験手法 X-RAY DIFFRACTION (2.301 Å) 主引用文献 Crystal Structures of Penicillin-Binding Protein 3 (PBP3) from Methicillin-Resistant Staphylococcus aureus in the Apo and Cefotaxime-Bound Forms. J.Mol.Biol., 423, 2012
6I1E	Crystal structure of Pseudomonas aeruginosa Penicillin-Binding Protein 3 in complex with amoxicillin 分子名称: 2-{1-[2-AMINO-2-(4-HYDROXY-PHENYL)-ACETYLAMINO]-2-OXO-ETHYL}-5,5-DIMETHYL-THIAZOLIDINE-4-CARBOXYLIC ACID, Peptidoglycan D,D-transpeptidase FtsI 著者 Bellini, D, Dowson, C.G. 登録日 2018-10-28 公開日 2019-11-20 最終更新日 2024-01-24 実験手法 X-RAY DIFFRACTION (1.64 Å) 主引用文献 Novel and Improved Crystal Structures of H. influenzae, E. coli and P. aeruginosa Penicillin-Binding Protein 3 (PBP3) and N. gonorrhoeae PBP2: Toward a Better Understanding of beta-Lactam Target-Mediated Resistance. J.Mol.Biol., 431, 2019
6UN3	Crystal structure of Pseudomonas aeruginosa PBP3 in complex with ticarcillin 分子名称: (2R,4S)-2-[(1R)-1-{[(2R)-2-carboxy-2-(thiophen-3-yl)acetyl]amino}-2-oxoethyl]-5,5-dimethyl-1,3-thiazolidine-4-carboxylic acid, CALCIUM ION, GLYCEROL, ... 著者 Sacco, M, Chen, Y. 登録日 2019-10-10 公開日 2019-10-30 最終更新日 2023-10-11 実験手法 X-RAY DIFFRACTION (1.9 Å) 主引用文献 Influence of the alpha-Methoxy Group on the Reaction of Temocillin with Pseudomonas aeruginosa PBP3 and CTX-M-14 beta-Lactamase. Antimicrob.Agents Chemother., 64, 2019
3VSL	Crystal structure of penicillin-binding protein 3 (PBP3) from methicilin-resistant Staphylococcus aureus in the cefotaxime bound form. 分子名称: CEFOTAXIME, C3' cleaved, open, ... 著者 Yoshida, H, Tame, J.R, Park, S.Y. 登録日 2012-04-25 公開日 2012-10-31 最終更新日 2017-03-15 実験手法 X-RAY DIFFRACTION (2.4 Å) 主引用文献 Crystal Structures of Penicillin-Binding Protein 3 (PBP3) from Methicillin-Resistant Staphylococcus aureus in the Apo and Cefotaxime-Bound Forms. J.Mol.Biol., 423, 2012
6UN1	Crystal structure of Pseudomonas aeruginosa PBP3 in complex with temocillin 分子名称: (2R,4S)-2-[(1S)-1-{[(2R)-2-carboxy-2-(thiophen-3-yl)acetyl]amino}-1-methoxy-2-oxoethyl]-5,5-dimethyl-1,3-thiazolidine-4 -carboxylic acid, Peptidoglycan D,D-transpeptidase FtsI 著者 Sacco, M, Chen, Y. 登録日 2019-10-10 公開日 2019-10-30 最終更新日 2023-10-11 実験手法 X-RAY DIFFRACTION (2.26 Å) 主引用文献 Influence of the alpha-Methoxy Group on the Reaction of Temocillin with Pseudomonas aeruginosa PBP3 and CTX-M-14 beta-Lactamase. Antimicrob.Agents Chemother., 64, 2019
6H5O	Crystal structure of PBP2a from MRSA in complex with piperacillin at active site. 分子名称: CADMIUM ION, Penicillin binding protein 2 prime, Piperacillin (Open Form) 著者 Batuecas, M.T, Martinez-Caballero, S, Hermoso, J.A. 登録日 2018-07-25 公開日 2019-08-14 最終更新日 2024-01-17 実験手法 X-RAY DIFFRACTION (2.82 Å) 主引用文献 The Quinazolinone Allosteric Inhibitor of PBP 2a Synergizes with Piperacillin and Tazobactam against Methicillin-Resistant Staphylococcus aureus. Antimicrob.Agents Chemother., 63, 2019
5LP5	Complex between Penicillin-Binding Protein (PBP2) and MreC from Helicobacter pylori 分子名称: Penicillin-binding protein 2 (Pbp2), Rod shape-determining protein (MreC) 著者 Contreras-Martel, C, Martins, A, Ecobichon, C, Maragno, D.M, Mattei, P.J, El Ghachi, M, Hicham, S, Hardouin, P, Boneca, I.G, Dessen, A. 登録日 2016-08-11 公開日 2017-08-23 最終更新日 2024-01-10 実験手法 X-RAY DIFFRACTION (2.74 Å) 主引用文献 Molecular architecture of the PBP2-MreC core bacterial cell wall synthesis complex. Nat Commun, 8, 2017
5M1A	Crystal structure of PBP2a from MRSA in the presence of Ceftazidime ligand 分子名称: CADMIUM ION, Penicillin-binding protein 2, beta-muramic acid 著者 Molina, R, Batuecas, M.T, Hermoso, J.A. 登録日 2016-10-07 公開日 2017-02-08 最終更新日 2024-01-17 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 Conformational Dynamics in Penicillin-Binding Protein 2a of Methicillin-Resistant Staphylococcus aureus, Allosteric Communication Network and Enablement of Catalysis. J. Am. Chem. Soc., 139, 2017
3PBO	Crystal structure of PBP3 complexed with ceftazidime 分子名称: ACYLATED CEFTAZIDIME, Penicillin-binding protein 3 著者 Han, S. 登録日 2010-10-20 公開日 2010-12-22 最終更新日 2011-07-13 実験手法 X-RAY DIFFRACTION (1.74 Å) 主引用文献 Structural basis for effectiveness of siderophore-conjugated monocarbams against clinically relevant strains of Pseudomonas aeruginosa. Proc.Natl.Acad.Sci.USA, 107, 2010
3PBT	Crystal structure of PBP3 complexed with MC-1 分子名称: (4S,7Z)-7-(2-amino-1,3-thiazol-4-yl)-1-[({4-[(2R)-2,3-dihydroxypropyl]-3-(4,5-dihydroxypyridin-2-yl)-5-oxo-4,5-dihydro-1H-1,2,4-triazol-1-yl}sulfonyl)amino]-4-formyl-10,10-dimethyl-1,6-dioxo-9-oxa-2,5,8-triazaundec-7-en-11-oate, Penicillin-binding protein 3 著者 Han, S, Evdokimov, A. 登録日 2010-10-20 公開日 2010-12-22 最終更新日 2012-02-08 実験手法 X-RAY DIFFRACTION (1.641 Å) 主引用文献 Structural basis for effectiveness of siderophore-conjugated monocarbams against clinically relevant strains of Pseudomonas aeruginosa. Proc.Natl.Acad.Sci.USA, 107, 2010

<1234567>