PDB: 74 resultsInfo pagesStatus searchChemie searchBIRD

---

7JFY	GAS41 YEATS domain in complex with 5 Descriptor: 1,2-ETHANEDIOL, DIMETHYL SULFOXIDE, N-(5-{3-[(2S)-1,3-thiazolidin-2-yl]azetidine-1-carbonyl}thiophen-2-yl)-L-prolinamide, ... Authors: Linhares, B.M, Listunov, D, Winkler, A, Grembecka, J, Cierpicki, T. Deposit date: 2020-07-17 Release date: 2021-07-21 Last modified: 2023-10-18 Method: X-RAY DIFFRACTION (2.100557 Å) Cite: GAS41 YEATS domain in complex with 5 To Be Published
7F4A	Crystal structure of Taf14 YEATS domain in complex with H3K9bz peptide Descriptor: Histone H3, Transcription initiation factor TFIID subunit 14 Authors: Wang, D, Yan, F, Yong, C. Deposit date: 2021-06-18 Release date: 2022-03-16 Last modified: 2023-11-29 Method: X-RAY DIFFRACTION (2 Å) Cite: Global profiling of regulatory elements in the histone benzoylation pathway. Nat Commun, 13, 2022
7F5M	Crystal structure of Sas5 YEATS domain in complex with H3K27bz peptide Descriptor: GLYCEROL, LYS-GLN-LEU-ALA-SER-LYS-ALA-ALA-ARG-LBZ-SER-ALA-PRO-SER-THR-GLY-GLY-VAL-LYS-TYR, Something about silencing protein 5 Authors: Wang, D, Yan, F, Chen, Y. Deposit date: 2021-06-22 Release date: 2022-03-16 Last modified: 2023-11-29 Method: X-RAY DIFFRACTION (2.4 Å) Cite: Global profiling of regulatory elements in the histone benzoylation pathway. Nat Commun, 13, 2022
7EIC	Crystal structure of AF9 YEATS domain in complex with H4K5acK8ac peptide Descriptor: DI(HYDROXYETHYL)ETHER, GLYCEROL, Histone H4, ... Authors: Kikuchi, M, Umehara, T. Deposit date: 2021-03-30 Release date: 2022-04-06 Last modified: 2023-11-29 Method: X-RAY DIFFRACTION (1.95 Å) Cite: Elucidation of binding preferences of YEATS domains to site-specific acetylated nucleosome core particles. J.Biol.Chem., 298, 2022
7EID	Crystal structure of AF9 YEATS domain in complex with H4K8acK12ac peptide Descriptor: GLYCEROL, Histone H4, Protein AF-9 Authors: Kikuchi, M, Umehara, T. Deposit date: 2021-03-30 Release date: 2022-04-06 Last modified: 2023-11-29 Method: X-RAY DIFFRACTION (2 Å) Cite: Elucidation of binding preferences of YEATS domains to site-specific acetylated nucleosome core particles. J.Biol.Chem., 298, 2022
7E7C	Crystal structure of ENL YEATS domain T1 mutant in complex with histone H3 acetylation at K27 Descriptor: 1,2-ETHANEDIOL, Histone H3K27ac(24-27) peptide, IODIDE ION, ... Authors: Li, Y, Li, H. Deposit date: 2021-02-25 Release date: 2022-04-06 Last modified: 2023-11-29 Method: X-RAY DIFFRACTION (1.84 Å) Cite: Crystal structure of ENL YEATS domain T1 mutant in complex with histone H3 acetylation at K27 To Be Published
7EIE	Crystal structure of YEATS2 YEATS domain Descriptor: GLYCEROL, YEATS domain-containing protein 2 Authors: Kikuchi, M, Umehara, T. Deposit date: 2021-03-30 Release date: 2022-04-06 Last modified: 2023-11-29 Method: X-RAY DIFFRACTION (1.67 Å) Cite: Elucidation of binding preferences of YEATS domains to site-specific acetylated nucleosome core particles. J.Biol.Chem., 298, 2022
7EIF	Crystal structure of GAS41 YEATS domain Descriptor: GLYCEROL, YEATS domain-containing protein 4 Authors: Kikuchi, M, Umehara, T. Deposit date: 2021-03-30 Release date: 2022-04-06 Last modified: 2023-11-29 Method: X-RAY DIFFRACTION (1.58 Å) Cite: GAS41 promotes H2A.Z deposition through recognition of the N terminus of histone H3 by the YEATS domain. Proc.Natl.Acad.Sci.USA, 120, 2023
7VKH	Crystal structure of AF9 YEATS domain in complex with hit 2 Descriptor: GLYCEROL, Protein AF-9, ~{N}-(3-azanyl-4-chloranyl-phenyl)-2-methoxy-ethanamide Authors: Liu, Y, Ruan, K. Deposit date: 2021-09-30 Release date: 2022-10-05 Last modified: 2023-11-29 Method: X-RAY DIFFRACTION (2.25 Å) Cite: Fragment-Based Discovery of AF9 YEATS Domain Inhibitors. Int J Mol Sci, 23, 2022
7VKG	Crystal structure of AF9 YEATS domain in complex with Compound 10 Descriptor: 1,2-ETHANEDIOL, CHLORIDE ION, Protein AF-9, ... Authors: Liu, Y, Ruan, K. Deposit date: 2021-09-29 Release date: 2022-10-05 Last modified: 2023-11-29 Method: X-RAY DIFFRACTION (1.83 Å) Cite: Fragment-Based Discovery of AF9 YEATS Domain Inhibitors. Int J Mol Sci, 23, 2022
8DKB	Crystal Structure of human YEATS4 in complex with Pfizer small molecule compound 3b Descriptor: N-ethyl-1-{(3S,4S)-1-[(1-hydroxycyclohexyl)methyl]-3-methylpiperidin-4-yl}-2-methyl-1H-benzimidazole-5-carboxamide, YEATS domain-containing protein 4 Authors: Dias, J.M, Byrnes, L.J, Varghese, A.H. Deposit date: 2022-07-05 Release date: 2023-01-11 Last modified: 2023-10-25 Method: X-RAY DIFFRACTION (2.58 Å) Cite: Discovery of High-Affinity Small-Molecule Binders of the Epigenetic Reader YEATS4. J.Med.Chem., 66, 2023
7X8G	Crystal structure of ENL T1(H116P) mutant YEATS domain in complex with histone H3 acetylation at K27 Descriptor: H3K27ac(24-27) peptide, Protein ENL Authors: Li, Y, Peng, B, Li, H. Deposit date: 2022-03-12 Release date: 2023-01-18 Last modified: 2023-11-29 Method: X-RAY DIFFRACTION (1.91 Å) Cite: Hotspot mutations in the structured ENL YEATS domain link aberrant transcriptional condensates and cancer. Mol.Cell, 82, 2022
7X8B	Crystal structure of ENL T1 mutant YEATS domain in complex with histone H3 acetylation at K27 Descriptor: H3K27ac(24-27) peptide, Protein ENL Authors: Li, Y, Peng, B, Li, H. Deposit date: 2022-03-11 Release date: 2023-01-18 Last modified: 2023-11-29 Method: X-RAY DIFFRACTION (2.3 Å) Cite: Hotspot mutations in the structured ENL YEATS domain link aberrant transcriptional condensates and cancer. Mol.Cell, 82, 2022
7X8F	Crystal structure of ENL T4 mutant YEATS domain in complex with histone H3 acetylation at K27 Descriptor: CHLORIDE ION, H3K27ac(24-27) peptide, Protein ENL Authors: Li, Y, Peng, B, Li, H. Deposit date: 2022-03-12 Release date: 2023-01-18 Last modified: 2023-11-29 Method: X-RAY DIFFRACTION (2.44 Å) Cite: Hotspot mutations in the structured ENL YEATS domain link aberrant transcriptional condensates and cancer. Mol.Cell, 82, 2022
7X88	Crystal structure of ENL YEATS domain T2 mutant in complex with histone H3 acetylation at K27 Descriptor: CITRIC ACID, Histone H3K27ac(24-27) peptide, Protein ENL Authors: Li, Y.Y, Li, H.T. Deposit date: 2022-03-11 Release date: 2023-01-18 Last modified: 2023-11-29 Method: X-RAY DIFFRACTION (2.25 Å) Cite: Hotspot mutations in the structured ENL YEATS domain link aberrant transcriptional condensates and cancer. Mol.Cell, 82, 2022
8I60	Crystal structure of GAS41 YEATS domain in complex with histone H3K27cr Descriptor: ALA-ARG-KCR-SER-ALA-PRO, GLYCEROL, SULFATE ION, ... Authors: Konuma, T, Zhou, M.-M. Deposit date: 2023-01-26 Release date: 2023-07-26 Method: X-RAY DIFFRACTION (2.3 Å) Cite: Histone H3 lysine 27 crotonylation mediates gene transcriptional repression in chromatin. Mol.Cell, 83, 2023
8IIY	Crystal structure of MBP fused GAS41 YEATS domain in complex with H3K14ac peptide Descriptor: GLYCEROL, Histone H3.1, Maltodextrin-binding protein,YEATS domain-containing protein 4, ... Authors: Kikuchi, M, Umehara, T. Deposit date: 2023-02-24 Release date: 2023-11-01 Last modified: 2023-11-15 Method: X-RAY DIFFRACTION (2.15 Å) Cite: GAS41 promotes H2A.Z deposition through recognition of the N terminus of histone H3 by the YEATS domain. Proc.Natl.Acad.Sci.USA, 120, 2023
8IIZ	Crystal structure of MBP fused GAS41 YEATS domain in complex with H3K27ac peptide Descriptor: GLYCEROL, Histone H3.1, Maltodextrin-binding protein,YEATS domain-containing protein 4, ... Authors: Kikuchi, M, Umehara, T. Deposit date: 2023-02-24 Release date: 2023-11-01 Last modified: 2023-11-15 Method: X-RAY DIFFRACTION (2.1 Å) Cite: GAS41 promotes H2A.Z deposition through recognition of the N terminus of histone H3 by the YEATS domain. Proc.Natl.Acad.Sci.USA, 120, 2023
8IJ0	Crystal structure of GAS41 YEATS domain in complex with H3K9ac peptide Descriptor: GLYCEROL, Histone H3.1, PENTAETHYLENE GLYCOL, ... Authors: Kikuchi, M, Umehara, T. Deposit date: 2023-02-24 Release date: 2023-11-01 Last modified: 2023-11-15 Method: X-RAY DIFFRACTION (1.52 Å) Cite: GAS41 promotes H2A.Z deposition through recognition of the N terminus of histone H3 by the YEATS domain. Proc.Natl.Acad.Sci.USA, 120, 2023
8PJI	MLLT1 in complex with compound 10a Descriptor: 1,2-ETHANEDIOL, DIMETHYL SULFOXIDE, Protein ENL, ... Authors: Raux, B, Diaz-Saez, L, Huber, K.V.M, Fedorov, O, Owen, D.R, Londregan, A.T, Bountra, C, Edwards, A, Arrowsmith, C. Deposit date: 2023-06-23 Release date: 2023-11-22 Last modified: 2023-12-27 Method: X-RAY DIFFRACTION (1.7 Å) Cite: Discovery of PFI-6, a small-molecule chemical probe for the YEATS domain of MLLT1 and MLLT3. Bioorg.Med.Chem.Lett., 98, 2023
8PJ7	MLLT3 in complex with compound PFI-6 Descriptor: 1,2-ETHANEDIOL, DIMETHYL SULFOXIDE, PHOSPHATE ION, ... Authors: Raux, B, Diaz-Saez, L, Huber, K.V.M, Fedorov, O, Owen, D.R, Londregan, A.T, Bountra, C, Edwards, A, Arrowsmith, C. Deposit date: 2023-06-22 Release date: 2023-11-22 Last modified: 2023-12-27 Method: X-RAY DIFFRACTION (1.26 Å) Cite: Discovery of PFI-6, a small-molecule chemical probe for the YEATS domain of MLLT1 and MLLT3. Bioorg.Med.Chem.Lett., 98, 2023
8X1C	Structure of nucleosome-bound SRCAP-C in the ADP-bound state Descriptor: ADENOSINE-5'-DIPHOSPHATE, ADENOSINE-5'-TRIPHOSPHATE, Actin, ... Authors: Yu, J, Wang, Q, Yu, Z, Li, W, Wang, L, Xu, Y. Deposit date: 2023-11-06 Release date: 2024-03-06 Method: ELECTRON MICROSCOPY (3.2 Å) Cite: Structure of nucleosome-bound SRCAP-C in the ADP-bound state To Be Published
8X19	Structure of nucleosome-bound SRCAP-C in the ADP-BeFx-bound state Descriptor: ADENOSINE-5'-DIPHOSPHATE, ADENOSINE-5'-TRIPHOSPHATE, Actin, ... Authors: Yu, J, Wang, Q, Yu, Z, Li, W, Wang, L, Xu, Y. Deposit date: 2023-11-06 Release date: 2024-03-06 Method: ELECTRON MICROSCOPY (3.2 Å) Cite: Structure of nucleosome-bound SRCAP-C in the ADP-BeFx-bound state To Be Published
8X15	Structure of nucleosome-bound SRCAP-C in the apo state Descriptor: ADENOSINE-5'-DIPHOSPHATE, ADENOSINE-5'-TRIPHOSPHATE, Actin, ... Authors: Yu, J, Wang, Q, Yu, Z, Li, W, Wang, L, Xu, Y. Deposit date: 2023-11-06 Release date: 2024-03-06 Method: ELECTRON MICROSCOPY (3.2 Å) Cite: Structure of nucleosome-bound SRCAP-C in the apo state To Be Published

<123