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1BDM	THE STRUCTURE AT 1.8 ANGSTROMS RESOLUTION OF A SINGLE SITE MUTANT (T189I) OF MALATE DEHYDROGENASE FROM THERMUS FLAVUS WITH INCREASED ENZYMATIC ACTIVITY Descriptor: BETA-6-HYDROXY-1,4,5,6-TETRHYDRONICOTINAMIDE ADENINE DINUCLEOTIDE, MALATE DEHYDROGENASE Authors: Kelly, C.A, Birktoft, J.J. Deposit date: 1993-02-16 Release date: 1994-12-20 Last modified: 2024-02-07 Method: X-RAY DIFFRACTION (1.8 Å) Cite: Determinants of protein thermostability observed in the 1.9-A crystal structure of malate dehydrogenase from the thermophilic bacterium Thermus flavus. Biochemistry, 32, 1993
5IXY	Lactate Dehydrogenase in complex with hydroxylactam inhibitor compound 31: (2~{S})-5-(2-chlorophenyl)sulfanyl-2-(4-morpholin-4-ylphenyl)-4-oxidanyl-2-thiophen-3-yl-1,3-dihydropyridin-6-one Descriptor: (2~{S})-5-(2-chlorophenyl)sulfanyl-2-(4-morpholin-4-ylphenyl)-4-oxidanyl-2-thiophen-3-yl-1,3-dihydropyridin-6-one, L-lactate dehydrogenase A chain, NICOTINAMIDE-ADENINE-DINUCLEOTIDE, ... Authors: Chen, Z, Eigenbrot, C. Deposit date: 2016-03-23 Release date: 2016-09-14 Last modified: 2023-09-27 Method: X-RAY DIFFRACTION (3 Å) Cite: Cell Active Hydroxylactam Inhibitors of Human Lactate Dehydrogenase with Oral Bioavailability in Mice. Acs Med.Chem.Lett., 7, 2016
5IXS	Lactate Dehydrogenase in complex with hydroxylactam inhibitor compound 9: (6R)-3-[(2-chlorophenyl)sulfanyl]-4-hydroxy-6-(3-hydroxyphenyl)-6-(thiophen-3-yl)-5,6-dihydropyridin-2(1H)-one Descriptor: (6R)-3-[(2-chlorophenyl)sulfanyl]-4-hydroxy-6-(3-hydroxyphenyl)-6-(thiophen-3-yl)-5,6-dihydropyridin-2(1H)-one, 1,4,5,6-TETRAHYDRONICOTINAMIDE ADENINE DINUCLEOTIDE, 1,4-DIHYDRONICOTINAMIDE ADENINE DINUCLEOTIDE, ... Authors: Ultsch, M, Eigenbrot, C. Deposit date: 2016-03-23 Release date: 2016-09-14 Last modified: 2023-09-27 Method: X-RAY DIFFRACTION (2.05 Å) Cite: Cell Active Hydroxylactam Inhibitors of Human Lactate Dehydrogenase with Oral Bioavailability in Mice. Acs Med.Chem.Lett., 7, 2016
3D0O	Crystal structure of Lactate Dehydrogenase from Staphylococcus Aureus Descriptor: L-lactate dehydrogenase 1 Authors: Ho, M, Gutierrez, J.A, Almo, S.C, Schramm, V.L. Deposit date: 2008-05-02 Release date: 2009-05-12 Last modified: 2024-02-21 Method: X-RAY DIFFRACTION (1.8 Å) Cite: Crystal structure of Lactate Dehydrogenase from Staphylococcus Aureus To be Published
3D4P	Crystal structure of Lactate Dehydrogenase from Staphylococcus Aureus complexed with NAD and pyruvate Descriptor: L-lactate dehydrogenase 1, NICOTINAMIDE-ADENINE-DINUCLEOTIDE, PYRUVIC ACID Authors: Schramm, V.L, Almo, S.C, Gutierrez, J.A, Ho, M. Deposit date: 2008-05-14 Release date: 2009-06-02 Last modified: 2023-11-15 Method: X-RAY DIFFRACTION (1.8 Å) Cite: Crystal structure of Lactate Dehydrogenase from Staphylococcus Aureus complexed with NAD and pyruvate To be Published
3CZM	T. Gondii bradyzoite-specific LDH (LDH2) in complex with NAD and OXQ Descriptor: 4-HYDROXY-1,2,5-OXADIAZOLE-3-CARBOXYLIC ACID, L-lactate dehydrogenase, NICOTINAMIDE-ADENINE-DINUCLEOTIDE Authors: Wilson, D.K, Susko, M.S. Deposit date: 2008-04-29 Release date: 2009-06-02 Last modified: 2023-08-30 Method: X-RAY DIFFRACTION (2.3 Å) Cite: T. Gondii bradyzoite-specific LDH (LDH2) in complex with NAD and OXQ To be Published
7EPM	human LDHC complexed with NAD+ and ethylamino acetic acid Descriptor: 2-(ethylamino)-2-oxidanylidene-ethanoic acid, L-lactate dehydrogenase C chain, NICOTINAMIDE-ADENINE-DINUCLEOTIDE, ... Authors: Yu, Y, Chen, Q. Deposit date: 2021-04-27 Release date: 2022-03-02 Last modified: 2023-11-29 Method: X-RAY DIFFRACTION (3 Å) Cite: Identification of human LDHC4 as a potential target for anticancer drug discovery. Acta Pharm Sin B, 12, 2022
1BMD	DETERMINANTS OF PROTEIN THERMOSTABILITY OBSERVED IN THE 1.9 ANGSTROMS CRYSTAL STRUCTURE OF MALATE DEHYDROGENASE FROM THE THERMOPHILIC BACTERIUM THERMUS FLAVUS Descriptor: MALATE DEHYDROGENASE, NICOTINAMIDE-ADENINE-DINUCLEOTIDE Authors: Kelly, C.A, Birktoft, J.J. Deposit date: 1992-11-10 Release date: 1994-07-31 Last modified: 2024-02-07 Method: X-RAY DIFFRACTION (1.9 Å) Cite: Determinants of protein thermostability observed in the 1.9-A crystal structure of malate dehydrogenase from the thermophilic bacterium Thermus flavus. Biochemistry, 32, 1993
4I9U	Crystal structure of rabbit LDHA in complex with a fragment inhibitor AP26256 Descriptor: 6-({2-[(5-chloro-2-methoxyphenyl)amino]-2-oxoethyl}sulfanyl)pyridine-3-carboxylic acid, L-lactate dehydrogenase A chain Authors: Zhou, T, Kohlmann, A, Stephan, Z.G, Commodore, L, Greenfield, M.T, Zhu, X, Dalgarno, D.C. Deposit date: 2012-12-05 Release date: 2013-01-23 Last modified: 2023-09-20 Method: X-RAY DIFFRACTION (2.5 Å) Cite: Fragment growing and linking lead to novel nanomolar lactate dehydrogenase inhibitors. J.Med.Chem., 56, 2013
7CGD	Silver-bound E.coli malate dehydrogenase Descriptor: Malate dehydrogenase, SILVER ION Authors: Wang, H, Wang, M, Sun, H. Deposit date: 2020-07-01 Release date: 2020-09-23 Last modified: 2023-11-29 Method: X-RAY DIFFRACTION (2.06 Å) Cite: Atomic differentiation of silver binding preference in protein targets: Escherichia coli malate dehydrogenase as a paradigm. Chem Sci, 11, 2020
5K0Z	Cryo-EM structure of lactate dehydrogenase (LDH) in inhibitor-bound state Descriptor: L-lactate dehydrogenase B chain Authors: Merk, A, Bartesaghi, A, Banerjee, S, Falconieri, V, Rao, P, Earl, L, Milne, J, Subramaniam, S. Deposit date: 2016-05-17 Release date: 2016-06-08 Last modified: 2024-03-06 Method: ELECTRON MICROSCOPY (2.8 Å) Cite: Breaking Cryo-EM Resolution Barriers to Facilitate Drug Discovery. Cell, 165, 2016
4H7P	Crystal structure of a putative Cytosolic malate dehydrogenase from Leishmania major Friedlin Descriptor: Malate dehydrogenase, SULFATE ION Authors: Seattle Structural Genomics Center for Infectious Disease (SSGCID) Deposit date: 2012-09-20 Release date: 2012-10-10 Last modified: 2023-09-20 Method: X-RAY DIFFRACTION (1.3 Å) Cite: Crystal structure of a putative Cytosolic malate dehydrogenase from Leishmania major Friedlin To be Published
4I9H	Crystal structure of rabbit LDHA in complex with AP28669 Descriptor: 1-O-[3-(5-carboxypyridin-2-yl)-5-fluorophenyl]-6-O-[4-({[(5-carboxypyridin-2-yl)sulfanyl]acetyl}amino)-2-chloro-5-methoxyphenyl]-D-mannitol, L-lactate dehydrogenase A chain Authors: Zhou, T, Stephan, Z.G, Kohlmann, A, Li, F, Commodore, L, Greenfield, M.T, Shakespeare, W.C, Zhu, X, Dalgarno, D.C. Deposit date: 2012-12-05 Release date: 2013-01-23 Last modified: 2023-09-20 Method: X-RAY DIFFRACTION (2.17 Å) Cite: Fragment growing and linking lead to novel nanomolar lactate dehydrogenase inhibitors. J.Med.Chem., 56, 2013
4I8X	Crystal structure of rabbit LDHA in complex with AP27460 Descriptor: 6-phenylpyridine-3-carboxylic acid, L-lactate dehydrogenase A chain Authors: Zhou, T, Stephan, Z.G, Kohlmann, A, Li, F, Commodore, L, Greenfield, M.T, Zhu, X, Dalgarno, D.C. Deposit date: 2012-12-04 Release date: 2013-01-23 Last modified: 2023-09-20 Method: X-RAY DIFFRACTION (2.23 Å) Cite: Fragment growing and linking lead to novel nanomolar lactate dehydrogenase inhibitors. J.Med.Chem., 56, 2013
4I9N	Crystal structure of rabbit LDHA in complex with AP28161 and AP28122 Descriptor: 6-({2-[(5-chloro-4-{[(2S)-2,3-dihydroxypropyl]oxy}-2-methoxyphenyl)amino]-2-oxoethyl}sulfanyl)pyridine-3-carboxylic acid, 6-[3-(carboxymethoxy)-5-fluorophenyl]pyridine-3-carboxylic acid, L-lactate dehydrogenase A chain Authors: Zhou, T, Kohlmann, A, Stephan, Z.G, Li, F, Commodore, L, Greenfield, M.T, Shakespeare, W.C, Zhu, X, Dalgarno, D.C. Deposit date: 2012-12-05 Release date: 2013-01-23 Last modified: 2023-09-20 Method: X-RAY DIFFRACTION (2.35 Å) Cite: Fragment growing and linking lead to novel nanomolar lactate dehydrogenase inhibitors. J.Med.Chem., 56, 2013
7F8D	Malate Dehydrogenase from Geobacillus stearothermophilus (gs-MDH) G218Y mutant Descriptor: Malate dehydrogenase, NICOTINAMIDE-ADENINE-DINUCLEOTIDE Authors: Shimozawa, Y, Himiyama, T, Nakamura, T, Nishiya, Y. Deposit date: 2021-07-02 Release date: 2022-02-23 Last modified: 2023-11-29 Method: X-RAY DIFFRACTION (2.4 Å) Cite: Increasing loop flexibility affords low-temperature adaptation of a moderate thermophilic malate dehydrogenase from Geobacillus stearothermophilus. Protein Eng.Des.Sel., 34, 2021
3FI9	Crystal structure of malate dehydrogenase from Porphyromonas gingivalis Descriptor: Malate dehydrogenase Authors: Bonanno, J.B, Freeman, J, Bain, K.T, Miller, S, Romero, R, Wasserman, S, Sauder, J.M, Burley, S.K, Almo, S.C, New York SGX Research Center for Structural Genomics (NYSGXRC) Deposit date: 2008-12-11 Release date: 2008-12-23 Last modified: 2024-02-21 Method: X-RAY DIFFRACTION (1.9 Å) Cite: Crystal structure of malate dehydrogenase from Porphyromonas gingivalis To be Published
7CGC	Silver-bound E. coli Malate dehydrogenase (C113 and C251) Descriptor: Malate dehydrogenase, SILVER ION Authors: Wang, H, Wang, M, Sun, H. Deposit date: 2020-07-01 Release date: 2020-09-23 Last modified: 2023-11-29 Method: X-RAY DIFFRACTION (2.548 Å) Cite: Atomic differentiation of silver binding preference in protein targets: Escherichia coli malate dehydrogenase as a paradigm. Chem Sci, 11, 2020
4I1I	Crystal structure of a putative Cytosolic malate dehydrogenase from Leishmania major Friedlin in complex with NAD Descriptor: 1,2-ETHANEDIOL, Malate dehydrogenase, NICOTINAMIDE-ADENINE-DINUCLEOTIDE, ... Authors: Seattle Structural Genomics Center for Infectious Disease, Seattle Structural Genomics Center for Infectious Disease (SSGCID) Deposit date: 2012-11-21 Release date: 2012-12-19 Last modified: 2023-09-20 Method: X-RAY DIFFRACTION (1.5 Å) Cite: Crystal structure of a putative Cytosolic malate dehydrogenase from Leishmania major Friedlin in complex with NAD TO BE PUBLISHED
4UUO	Apo Trichomonas vaginalis malate dehydrogenase Descriptor: CYTOSOLIC MALATE DEHYDROGENASE Authors: Steindel, P.A, Chen, E.H, Theobald, D.L. Deposit date: 2014-07-29 Release date: 2015-08-12 Last modified: 2024-05-01 Method: X-RAY DIFFRACTION (2.842 Å) Cite: Gradual Neofunctionalization in the Convergent Evolution of Trichomonad Lactate and Malate Dehydrogenases. Protein Sci., 25, 2016
4WLF	Crystal structure of L-malate bound MDH2 Descriptor: (2S)-2-hydroxybutanedioic acid, Malate dehydrogenase, mitochondrial, ... Authors: Eo, Y.M, Han, B.G, Ahn, H.C. Deposit date: 2014-10-07 Release date: 2015-11-25 Last modified: 2023-11-08 Method: X-RAY DIFFRACTION (2.2 Å) Cite: Crystal structure of L-malate bound MDH2 To Be Published
4WLN	Crystal structure of apo MDH2 Descriptor: Malate dehydrogenase, mitochondrial, PHOSPHATE ION Authors: Eo, Y.M, Han, B.G, Ahn, H.C. Deposit date: 2014-10-07 Release date: 2015-11-25 Last modified: 2024-03-20 Method: X-RAY DIFFRACTION (2.28 Å) Cite: Crystal structure of apo MDH2 To Be Published
4WLE	Crystal structure of citrate bound MDH2 Descriptor: CITRIC ACID, Malate dehydrogenase, mitochondrial Authors: Eo, Y.M, Han, B.G, Ahn, H.C. Deposit date: 2014-10-07 Release date: 2015-11-25 Last modified: 2023-11-08 Method: X-RAY DIFFRACTION (1.9 Å) Cite: Crystal structure of citrate bound MDH2 To Be Published
4WLV	Crystal structure of NAD bound MDH2 Descriptor: Malate dehydrogenase, mitochondrial, NICOTINAMIDE-ADENINE-DINUCLEOTIDE, ... Authors: Eo, Y.M, Han, B.G, Ahn, H.C. Deposit date: 2014-10-08 Release date: 2015-11-25 Last modified: 2024-03-20 Method: X-RAY DIFFRACTION (2.4 Å) Cite: Crystal structure of NAD bound MDH2 To Be Published
1O6Z	1.95 A resolution structure of (R207S,R292S) mutant of malate dehydrogenase from the halophilic archaeon Haloarcula marismortui (holo form) Descriptor: CHLORIDE ION, MALATE DEHYDROGENASE, NICOTINAMIDE-ADENINE-DINUCLEOTIDE Authors: Irimia, A, Ebel, C, Madern, D, Richard, S.B, Cosenza, L.W, Zaccai, G, Vellieux, F.M.D. Deposit date: 2002-10-22 Release date: 2003-02-06 Last modified: 2023-12-13 Method: X-RAY DIFFRACTION (1.95 Å) Cite: The Oligomeric States of Haloarcula Marismortui Malate Dehydrogenase are Modulated by Solvent Components as Shown by Crystallographic and Biochemical Studies J.Mol.Biol., 326, 2003

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