3GLR
| Crystal Structure of human SIRT3 with acetyl-lysine AceCS2 peptide | Descriptor: | Acetyl-coenzyme A synthetase 2-like, mitochondrial, BICARBONATE ION, ... | Authors: | Jin, L, Wei, W, Jiang, Y, Peng, H, Cai, J, Mao, C, Dai, H, Bemis, J.E, Jirousek, M.R, Milne, J.C, Westphal, C.H, Perni, R.B. | Deposit date: | 2009-03-12 | Release date: | 2009-06-16 | Last modified: | 2019-07-24 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | Crystal Structures of Human SIRT3 Displaying Substrate-induced Conformational Changes. J.Biol.Chem., 284, 2009
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3GLT
| Crystal Structure of Human SIRT3 with ADPR bound to the AceCS2 peptide containing a thioacetyl lysine | Descriptor: | Acetyl-coenzyme A synthetase 2-like, mitochondrial, CARBONATE ION, ... | Authors: | Jin, L, Wei, W, Jiang, Y, Peng, H, Cai, J, Mao, C, Dai, H, Bemis, J.E, Jirousek, M.R, Milne, J.C, Westphal, C.H, Perni, R.B. | Deposit date: | 2009-03-12 | Release date: | 2009-06-16 | Last modified: | 2023-11-22 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | Crystal Structures of Human SIRT3 Displaying Substrate-induced Conformational Changes. J.Biol.Chem., 284, 2009
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3GLU
| Crystal Structure of Human SIRT3 with AceCS2 peptide | Descriptor: | Acetyl-coenzyme A synthetase 2-like, mitochondrial, NAD-dependent deacetylase sirtuin-3, ... | Authors: | Jin, L, Wei, W, Jiang, Y, Peng, H, Cai, J, Mao, C, Dai, H, Bemis, J.E, Jirousek, M.R, Milne, J.C, Westphal, C.H, Perni, R.B. | Deposit date: | 2009-03-12 | Release date: | 2009-06-16 | Last modified: | 2023-09-06 | Method: | X-RAY DIFFRACTION (2.5 Å) | Cite: | Crystal Structures of Human SIRT3 Displaying Substrate-induced Conformational Changes. J.Biol.Chem., 284, 2009
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8BL0
| Human Sirt6 in complex with the inhibitor S6023 and ADP-ribose | Descriptor: | 3-[4-[[5-(2-fluorophenyl)thiophen-2-yl]methyl]piperazin-1-yl]sulfonylbenzenesulfonamide, CHLORIDE ION, DI(HYDROXYETHYL)ETHER, ... | Authors: | You, W, Steegborn, C. | Deposit date: | 2022-11-09 | Release date: | 2023-11-22 | Method: | X-RAY DIFFRACTION (1.82 Å) | Cite: | Development of novel Sirtuin 6 inhibitors and activators based on a protein crystallography-based fragment screen To Be Published
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8BL1
| Human Sirt6 in complex with the inhibitor S6039 and ADP-ribose | Descriptor: | 2-azanyl-5-[4-[[5-(2-fluorophenyl)thiophen-2-yl]methyl]piperazin-1-yl]sulfonyl-benzenesulfonamide, CHLORIDE ION, DI(HYDROXYETHYL)ETHER, ... | Authors: | You, W, Steegborn, C. | Deposit date: | 2022-11-09 | Release date: | 2023-11-22 | Method: | X-RAY DIFFRACTION (2.06 Å) | Cite: | Development of novel Sirtuin 6 inhibitors and activators based on a protein crystallography-based fragment screen To Be Published
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6L65
| Sirtuin 2 protein with H3K18 myristoylated peptide | Descriptor: | MYRISTIC ACID, NAD-dependent protein deacetylase sirtuin-2, PRO-ARG-LYS-GLN-LEU, ... | Authors: | Chen, L.F. | Deposit date: | 2019-10-28 | Release date: | 2020-11-04 | Last modified: | 2023-11-22 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | Sirtuin 2 protein with H3K18 myristoylated peptide To Be Published
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6LJM
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6L66
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6LJN
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8CCW
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6LJK
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6L72
| Sirtuin 2 demyristoylation native final product | Descriptor: | NAD-dependent protein deacetylase sirtuin-2, ZINC ION, [(2S,3R,4R,5R)-5-[[[[(2R,3S,4R,5R)-5-(6-aminopurin-9-yl)-3,4-bis(oxidanyl)oxolan-2-yl]methoxy-oxidanyl-phosphoryl]oxy-oxidanyl-phosphoryl]oxymethyl]-2,4-bis(oxidanyl)oxolan-3-yl] tetradecanoate | Authors: | Chen, L.F. | Deposit date: | 2019-10-30 | Release date: | 2021-03-31 | Last modified: | 2023-11-22 | Method: | X-RAY DIFFRACTION (2.501 Å) | Cite: | Sirtuin 2 protein with H3K18 myristoylated peptide To Be Published
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6L71
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8CNO
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8CNM
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3JWP
| Crystal structure of Plasmodium falciparum SIR2A (PF13_0152) in complex with AMP | Descriptor: | ADENOSINE MONOPHOSPHATE, TRIETHYLENE GLYCOL, Transcriptional regulatory protein sir2 homologue, ... | Authors: | Wernimont, A.K, Hutchinson, A, Lin, Y.H, MacKenzie, F, Senisterra, G, Allali-Hassanali, A, Vedadi, M, Ravichandran, M, Cossar, D, Kozieradzki, I, Zhao, Y, Schapira, M, Arrowsmith, C.H, Bountra, C, Weigelt, J, Edwards, A.M, Hui, R, Qiu, W, Brand, V, Structural Genomics Consortium (SGC) | Deposit date: | 2009-09-18 | Release date: | 2009-10-20 | Last modified: | 2017-11-01 | Method: | X-RAY DIFFRACTION (2.65 Å) | Cite: | Crystal structure of Plasmodium falciparum SIR2A (PF13_0152) in complex with AMP TO BE PUBLISHED
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3K35
| Crystal Structure of Human SIRT6 | Descriptor: | ADENOSINE-5-DIPHOSPHORIBOSE, NAD-dependent deacetylase sirtuin-6, SULFATE ION, ... | Authors: | Pan, P.W, Dong, A, Qiu, W, Loppnau, P, Wang, J, Ravichandran, M, Bochkarev, A, Bountra, C, Weigelt, J, Arrowsmith, C.H, Min, J, Edwards, A.M, Structural Genomics Consortium (SGC) | Deposit date: | 2009-10-01 | Release date: | 2009-12-08 | Last modified: | 2023-09-06 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Structure and biochemical functions of SIRT6. J.Biol.Chem., 286, 2011
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3JR3
| Sir2 bound to acetylated peptide | Descriptor: | Acetylated Peptide, NAD-dependent deacetylase, ZINC ION | Authors: | Hawse, W.F, Wolberger, C. | Deposit date: | 2009-09-08 | Release date: | 2009-09-29 | Last modified: | 2023-11-22 | Method: | X-RAY DIFFRACTION (1.5 Å) | Cite: | Structure-based mechanism of ADP-ribosylation by sirtuins. J.Biol.Chem., 284, 2009
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3GLS
| Crystal Structure of Human SIRT3 | Descriptor: | NAD-dependent deacetylase sirtuin-3, mitochondrial, SULFATE ION, ... | Authors: | Jin, L, Wei, W, Jiang, Y, Peng, H, Cai, J, Mao, C, Dai, H, Bemis, J.E, Jirousek, M.R, Milne, J.C, Westphal, C.H, Perni, R.B. | Deposit date: | 2009-03-12 | Release date: | 2009-06-16 | Last modified: | 2023-09-06 | Method: | X-RAY DIFFRACTION (2.7 Å) | Cite: | Crystal Structures of Human SIRT3 Displaying Substrate-induced Conformational Changes. J.Biol.Chem., 284, 2009
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1M2J
| Sir2 homologue H80N mutant-ADP ribose complex | Descriptor: | ADENOSINE-5-DIPHOSPHORIBOSE, Silent Information Regulator 2, ZINC ION | Authors: | Chang, J, Cho, Y. | Deposit date: | 2002-06-24 | Release date: | 2003-04-08 | Last modified: | 2021-11-10 | Method: | X-RAY DIFFRACTION (1.7 Å) | Cite: | Structural basis for the NAD-dependent deacetylase mechanism of Sir2 J.BIOL.CHEM., 277, 2002
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1M2H
| Sir2 homologue S24A mutant-ADP ribose complex | Descriptor: | ADENOSINE-5-DIPHOSPHORIBOSE, Silent Information Regulator 2, ZINC ION | Authors: | Chang, J, Cho, Y. | Deposit date: | 2002-06-24 | Release date: | 2003-04-08 | Last modified: | 2021-11-10 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | Structural basis for the NAD-dependent deacetylase mechanism of Sir2 J.BIOL.CHEM., 277, 2002
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1M2N
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1MA3
| Structure of a Sir2 enzyme bound to an acetylated p53 peptide | Descriptor: | 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, Cellular tumor antigen p53, Transcriptional regulatory protein, ... | Authors: | Avalos, J.L, Celic, I, Muhammad, S, Cosgrove, M.S, Boeke, J.D, Wolberger, C. | Deposit date: | 2002-07-31 | Release date: | 2002-10-16 | Last modified: | 2011-07-13 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Structure of a Sir2 enzyme bound to an acetylated p53 peptide Mol.Cell, 10, 2002
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4UTN
| Crystal structure of zebrafish Sirtuin 5 in complex with succinylated CPS1-peptide | Descriptor: | 1,2-ETHANEDIOL, 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, DIMETHYL SULFOXIDE, ... | Authors: | Pannek, M, Gertz, M, Steegborn, C. | Deposit date: | 2014-07-21 | Release date: | 2014-08-20 | Last modified: | 2024-01-10 | Method: | X-RAY DIFFRACTION (3 Å) | Cite: | Chemical Probing of the Human Sirtuin 5 Active Site Reveals its Substrate Acyl Specificity and Peptide-Based Inhibitors. Angew.Chem.Int.Ed.Engl., 53, 2014
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4UU7
| Crystal structure of zebrafish Sirtuin 5 in complex with 3-methyl- succinylated CPS1-peptide | Descriptor: | (2R)-2-methylbutanedioic acid, (2S)-2-methylbutanedioic acid, 1,2-ETHANEDIOL, ... | Authors: | Pannek, M, Gertz, M, Steegborn, C. | Deposit date: | 2014-07-24 | Release date: | 2014-08-20 | Last modified: | 2024-01-31 | Method: | X-RAY DIFFRACTION (3 Å) | Cite: | Chemical Probing of the Human Sirtuin 5 Active Site Reveals its Substrate Acyl Specificity and Peptide-Based Inhibitors. Angew.Chem.Int.Ed.Engl., 53, 2014
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