6LJK

Crystal structure of human Sirt5 in complex with an internally quenched fluorescent substrate GluIQF

Summary for 6LJK

• Entry DOI: 10.2210/pdb6ljk/pdb
• Descriptor: NAD-dependent protein deacylase sirtuin-5, mitochondrial, BE2-SER-ALA-ILE-LYS-SER-NIY-GLY-SET, ZINC ION, ... (6 entities in total)
• Functional Keywords: sirt5, inhibitor, hydrolase, transferase
• Biological source: Homo sapiens (Human); More
• Total number of polymer chains: 2
• Total formula weight: 30765.21

Authors

Chen, Q.,Yu, Y. (deposition date: 2019-12-17, release date: 2020-12-23, Last modification date: 2023-11-22)

• Primary citation: Yang, L.L.,Wang, H.L.,Yan, Y.H.,Liu, S.,Yu, Z.J.,Huang, M.Y.,Luo, Y.,Zheng, X.,Yu, Y.,Li, G.B.; Sensitive fluorogenic substrates for sirtuin deacylase inhibitor discovery.; Eur.J.Med.Chem., 192:112201-112201, 2020; PubMed: 32163813; DOI: 10.1016/j.ejmech.2020.112201

Experimental method

X-RAY DIFFRACTION (1.394 Å)