6LJK
Crystal structure of human Sirt5 in complex with an internally quenched fluorescent substrate GluIQF
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | NAD-dependent protein deacylase sirtuin-5, mitochondrial | polymer | 272 | 29568.7 | 1 | UniProt (Q9NXA8) Pfam (PF02146) | Homo sapiens (Human) | Regulatory protein SIR2 homolog 5,SIR2-like protein 5 |
| 2 | B (B) | BE2-SER-ALA-ILE-LYS-SER-NIY-GLY-SET | polymer | 9 | 976.0 | 1 | synthetic construct | ||
| 3 | C (A) | ZINC ION | non-polymer | 65.4 | 1 | Chemie (ZN) | |||
| 4 | D (A) | SODIUM ION | non-polymer | 23.0 | 1 | Chemie (NA) | |||
| 5 | E (B) | GLUTARIC ACID | non-polymer | 132.1 | 1 | Chemie (GUA) | |||
| 6 | F, G (A, B) | water | water | 18.0 | 388 | Chemie (HOH) |
Sequence modifications
A: 34 - 302 (UniProt: Q9NXA8)
| PDB | External Database | Details |
|---|---|---|
| Gln 31 | - | expression tag |
| Ala 32 | - | expression tag |
| Ser 33 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 30544.7 | |
| Non-Polymers* | Number of molecules | 3 |
| Total formula weight | 220.5 | |
| All* | Total formula weight | 30765.2 |
