6LJK
Crystal structure of human Sirt5 in complex with an internally quenched fluorescent substrate GluIQF
Functional Information from GO Data
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 4 |
| Details | binding site for residue ZN A 401 |
| Chain | Residue |
| A | CYS166 |
| A | CYS169 |
| A | CYS207 |
| A | CYS212 |
| site_id | AC2 |
| Number of Residues | 5 |
| Details | binding site for residue NA A 402 |
| Chain | Residue |
| A | ALA59 |
| A | GLN140 |
| A | THR250 |
| A | SER251 |
| A | HOH694 |
| site_id | AC3 |
| Number of Residues | 8 |
| Details | binding site for residue GUA B 101 |
| Chain | Residue |
| A | ARG71 |
| A | TYR102 |
| A | ARG105 |
| A | HIS158 |
| A | VAL221 |
| A | HOH576 |
| B | LYS5 |
| B | HOH204 |
| site_id | AC4 |
| Number of Residues | 16 |
| Details | binding site for Ligand residues NIY D 7 through SET D 9 bound to SER D 6 |
| Chain | Residue |
| A | SER65 |
| A | ARG71 |
| A | GLN83 |
| A | GLU113 |
| A | PRO114 |
| A | ASN115 |
| A | ARG119 |
| A | PHE223 |
| A | VAL253 |
| A | HOH631 |
| A | HOH669 |
| A | HOH706 |
| B | SER6 |
| B | HOH201 |
| B | HOH203 |
| B | HOH207 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 1 |
| Details | Active site: {"description":"Proton acceptor","evidences":[{"source":"PROSITE-ProRule","id":"PRU00236","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"22076378","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"29180469","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 27 |
| Details | Binding site: {"evidences":[{"source":"HAMAP-Rule","id":"MF_03160","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"22076378","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"22767592","evidenceCode":"ECO:0000269"},{"source":"Reference","evidenceCode":"ECO:0000269","citation":{"citationType":"submission","publicationDate":"FEB-2006","submissionDatabase":"PDB data bank","title":"Crystal structure of human sirtuin homolog 5 in complex with NAD.","authoringGroup":["Structural genomics consortium (SGC)"]}}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 6 |
| Details | Binding site: {"evidences":[{"source":"HAMAP-Rule","id":"MF_03160","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
