4UU7

Crystal structure of zebrafish Sirtuin 5 in complex with 3-methyl- succinylated CPS1-peptide

Summary for 4UU7

Entry DOI	10.2210/pdb4uu7/pdb
Related	4UTN 4UTR 4UTV 4UTX 4UTZ 4UU8 4UUA 4UUB
Descriptor	NAD-DEPENDENT PROTEIN DEACYLASE SIRTUIN-5, MITOCHONDRIAL, CARBAMOYLPHOSPHATE SYNTHETASE I, ZINC ION, ... (10 entities in total)
Functional Keywords	hydrolase, sirtuin 5, regulatory enzyme, deacylase, mitochondrial, rossmann-fold, zinc-binding
Biological source	DANIO RERIO (ZEBRAFISH) More
Cellular location	Mitochondrion (By similarity): Q6DHI5
Total number of polymer chains	3
Total formula weight	62799.43
Authors	Pannek, M.,Gertz, M.,Steegborn, C. (deposition date: 2014-07-24, release date: 2014-08-20, Last modification date: 2024-01-31)
Primary citation	Roessler, C.,Nowak, T.,Pannek, M.,Gertz, M.,Nguyen, G.T.,Scharfe, M.,Born, I.,Sippl, W.,Steegborn, C.,Schutkowski, M. Chemical Probing of the Human Sirtuin 5 Active Site Reveals its Substrate Acyl Specificity and Peptide-Based Inhibitors. Angew.Chem.Int.Ed.Engl., 53:10728-, 2014 Cited by PubMed: 25111069 DOI: 10.1002/ANIE.201402679 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (3 Å)

Structure validation