8CNO

Improved complex structure of human Sirtuin 6 with its inhibitor cis-resveratrol

Summary for 8CNO

• Entry DOI: 10.2210/pdb8cno/pdb
• Descriptor: NAD-dependent protein deacetylase sirtuin-6, TRIETHYLENE GLYCOL, [(2R,3S,4R,5R)-5-(6-AMINOPURIN-9-YL)-3,4-DIHYDROXY-OXOLAN-2-YL]METHYL [HYDROXY-[[(2R,3S,4R,5S)-3,4,5-TRIHYDROXYOXOLAN-2-YL]METHOXY]PHOSPHORYL] HYDROGEN PHOSPHATE, ... (11 entities in total)
• Functional Keywords: deacylase, inhibitor, hydrolase
• Biological source: Homo sapiens (human)
• Total number of polymer chains: 2
• Total formula weight: 70621.06

Authors

You, W.,Steegborn, C. (deposition date: 2023-02-23, release date: 2024-03-06)

• Primary citation: You, W.,Steegborn, C.; Development of novel Sirtuin 6 inhibitors and activators based on a protein crystallography-based fragment screen; To Be Published,

Experimental method

X-RAY DIFFRACTION (1.75 Å)