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6PEO	Cryo-EM structure of alpha-synuclein H50Q Narrow Fibril Descriptor: Alpha-synuclein Authors: Boyer, D.R, Li, B, Sawaya, M.R, Jiang, L, Eisenberg, D.S. Deposit date: 2019-06-20 Release date: 2019-11-27 Last modified: 2024-03-20 Method: ELECTRON MICROSCOPY (3.3 Å) Cite: Structures of fibrils formed by alpha-synuclein hereditary disease mutant H50Q reveal new polymorphs. Nat.Struct.Mol.Biol., 26, 2019
6RTB	cryo-em structure of alpha-synuclein fibril polymorph 2B Descriptor: Alpha-synuclein Authors: Guerrero-Ferreira, R, Taylor, N.M.I, Arteni, A.A, Melki, R, Meier, B.H, Bockmann, A, Bousset, L, Stahlberg, H. Deposit date: 2019-05-22 Release date: 2019-06-26 Last modified: 2021-02-10 Method: ELECTRON MICROSCOPY (3.46 Å) Cite: Two new polymorphic structures of human full-length alpha-synuclein fibrils solved by cryo-electron microscopy. Elife, 8, 2019
6RT0	cryo-em structure of alpha-synuclein fibril polymorph 2A Descriptor: Alpha-synuclein Authors: Guerrero-Ferreira, R, Taylor, N.M.I, Arteni, A.A, Melki, R, Meier, B.H, Bockmann, A, Bousset, L, Stahlberg, H. Deposit date: 2019-05-22 Release date: 2019-06-26 Last modified: 2019-12-18 Method: ELECTRON MICROSCOPY (3.1 Å) Cite: Two new polymorphic structures of human full-length alpha-synuclein fibrils solved by cryo-electron microscopy. Elife, 8, 2019
6L1T	Cryo-EM structure of phosphorylated Tyr39 a-synuclein amyloid fibril Descriptor: Alpha-synuclein Authors: Liu, C, Li, Y.M, Zhao, K, Lim, Y.J, Liu, Z.Y. Deposit date: 2019-09-30 Release date: 2020-08-12 Last modified: 2020-09-02 Method: ELECTRON MICROSCOPY (3.22 Å) Cite: Parkinson's disease-related phosphorylation at Tyr39 rearranges alpha-synuclein amyloid fibril structure revealed by cryo-EM. Proc.Natl.Acad.Sci.USA, 117, 2020
6L1U	Cryo-EM structure of phosphorylated Tyr39 alpha-synuclein amyloid fibril Descriptor: Alpha-synuclein Authors: Liu, C, Li, Y.M, Zhao, K, Lim, Y.J, Liu, Z.Y. Deposit date: 2019-09-30 Release date: 2020-08-12 Last modified: 2020-09-02 Method: ELECTRON MICROSCOPY (3.37 Å) Cite: Parkinson's disease-related phosphorylation at Tyr39 rearranges alpha-synuclein amyloid fibril structure revealed by cryo-EM. Proc.Natl.Acad.Sci.USA, 117, 2020
6L4S	cryo-em structure of alpha-synuclein fiber mutation type E46K Descriptor: Alpha-synuclein Authors: Li, Y.W, Zhao, K, Liu, C, Li, X. Deposit date: 2019-10-21 Release date: 2020-04-29 Last modified: 2021-11-10 Method: ELECTRON MICROSCOPY (3.37 Å) Cite: Parkinson's disease associated mutation E46K of alpha-synuclein triggers the formation of a distinct fibril structure. Nat Commun, 11, 2020
6LRQ	Cryo-EM structure of A53T alpha-synuclein amyloid fibril Descriptor: Alpha-synuclein Authors: Sun, Y.P, Zhao, K, Liu, C. Deposit date: 2020-01-16 Release date: 2020-04-08 Last modified: 2024-03-27 Method: ELECTRON MICROSCOPY (3.49 Å) Cite: Cryo-EM structure of full-length alpha-synuclein amyloid fibril with Parkinson's disease familial A53T mutation. Cell Res., 30, 2020
6OSM	Cryo-EM structure of the N-terminally acetylated C-terminal Alpha-synuclein truncation Ac1-103 Descriptor: Alpha-synuclein Authors: Xiaodan, N, Ryan, P.M, Jiansen, J, Jennifer, C.L. Deposit date: 2019-05-01 Release date: 2019-09-25 Last modified: 2024-03-20 Method: ELECTRON MICROSCOPY (3.4 Å) Cite: Structural Insights into alpha-Synuclein Fibril Polymorphism: Effects of Parkinson's Disease-Related C-Terminal Truncations. J.Mol.Biol., 431, 2019
6OSJ	Cryo-EM structure of the N-terminally acetylated full length alpha-synuclein fibrils (Ac1-140) Descriptor: Alpha-synuclein Authors: Xiaodan, N, Ryan, P.M, Jiansen, J, Jennifer, C.L. Deposit date: 2019-05-01 Release date: 2019-09-25 Last modified: 2024-03-20 Method: ELECTRON MICROSCOPY (2.8 Å) Cite: Structural Insights into alpha-Synuclein Fibril Polymorphism: Effects of Parkinson's Disease-Related C-Terminal Truncations. J.Mol.Biol., 431, 2019
7LC9	Cryo-EM structure of the N-terminal alpha-synuclein truncation 41-140 Descriptor: Alpha-synuclein Authors: Xiaodan, N, Ryan, P.M, Jiansen, J, Jennifer, C.L. Deposit date: 2021-01-10 Release date: 2021-09-15 Method: ELECTRON MICROSCOPY (3.2 Å) Cite: The N terminus of alpha-synuclein dictates fibril formation. Proc.Natl.Acad.Sci.USA, 118, 2021
7L7H	Alpha-synuclein fibrils Descriptor: Alpha-synuclein Authors: Hojjatian, A, Dasari, A. Deposit date: 2020-12-28 Release date: 2022-01-12 Method: ELECTRON MICROSCOPY (4 Å) Cite: Distinct cryo-EM Structure of Alpha-synuclein Filaments derived by Tau To Be Published
7NCI	Type 2B alpha-synuclein filament seeded in vitro by filaments purified from Multiple Systems Atrophy Case 1 Descriptor: Alpha-synuclein Authors: Lovestam, S.K.A, Schweighauser, M, Scheres, S.H.W. Deposit date: 2021-01-28 Release date: 2021-02-24 Last modified: 2024-05-01 Method: ELECTRON MICROSCOPY (3.55 Å) Cite: Seeded assembly in vitro does not replicate the structures of alpha-synuclein filaments from multiple system atrophy. Febs Open Bio, 11, 2021
7NCH	Type 1B alpha-synuclein filament seeded in vitro by filaments purified from Multiple Systems Atrophy Case 1 Descriptor: Alpha-synuclein Authors: Lovestam, S.K.A, Schweighauser, M, Scheres, S.H.W. Deposit date: 2021-01-28 Release date: 2021-02-24 Last modified: 2024-05-01 Method: ELECTRON MICROSCOPY (3.84 Å) Cite: Seeded assembly in vitro does not replicate the structures of alpha-synuclein filaments from multiple system atrophy. Febs Open Bio, 11, 2021
7NCJ	Type 2AB alpha-synuclein filament seeded in vitro by filaments purified from Multiple Systems Atrophy Case 1 Descriptor: Alpha-synuclein Authors: Lovestam, S.K.A, Schweighauser, M, Scheres, S.H.W. Deposit date: 2021-01-28 Release date: 2021-02-24 Last modified: 2024-05-01 Method: ELECTRON MICROSCOPY (4.23 Å) Cite: Seeded assembly in vitro does not replicate the structures of alpha-synuclein filaments from multiple system atrophy. Febs Open Bio, 11, 2021
7NCK	Type 3 alpha-synuclein filament seeded in vitro by filaments purified from Multiple Systems Atrophy Case 5 Descriptor: Alpha-synuclein Authors: Lovestam, S.K.A, Schweighauser, M, Scheres, S.H.W. Deposit date: 2021-01-28 Release date: 2021-02-24 Last modified: 2024-05-01 Method: ELECTRON MICROSCOPY (3.18 Å) Cite: Seeded assembly in vitro does not replicate the structures of alpha-synuclein filaments from multiple system atrophy. Febs Open Bio, 11, 2021
7NCG	Type 2A alpha-synuclein filament seeded in vitro by filaments purified from Multiple Systems Atrophy Case 2 Descriptor: Alpha-synuclein Authors: Lovestam, S.K.A, Schweighauser, M, Scheres, S.H.W. Deposit date: 2021-01-28 Release date: 2021-02-24 Last modified: 2024-05-01 Method: ELECTRON MICROSCOPY (3.43 Å) Cite: Seeded assembly in vitro does not replicate the structures of alpha-synuclein filaments from multiple system atrophy. Febs Open Bio, 11, 2021
7NCA	Type 1A alpha-synuclein filament seeded in vitro by filaments purified from Multiple Systems Atrophy Case 2 Descriptor: Alpha-synuclein Authors: Lovestam, S.K.A, Schweighauser, M, Scheres, S.H.W. Deposit date: 2021-01-28 Release date: 2021-02-24 Last modified: 2024-05-01 Method: ELECTRON MICROSCOPY (3.47 Å) Cite: Seeded assembly in vitro does not replicate the structures of alpha-synuclein filaments from multiple system atrophy. Febs Open Bio, 11, 2021
8H03	Major polymorph in alpha-synuclein fibril seeded by cerebrospinal fluid from a preclinical Parkinson's disease patient Descriptor: Alpha-synuclein Authors: Fan, Y, Sun, Y.P, Wang, J, Liu, C. Deposit date: 2022-09-28 Release date: 2022-11-30 Last modified: 2023-01-25 Method: ELECTRON MICROSCOPY (2.8 Å) Cite: Conformational change of alpha-synuclein fibrils in cerebrospinal fluid from different clinical phases of Parkinson's disease. Structure, 31, 2023
8H04	Major polymorph in alpha-synuclein fibril seeded by cerebrospinal fluid from a postmortal Parkinson's disease patient Descriptor: Alpha-synuclein Authors: Fan, Y, Sun, Y.P, Wang, J, Liu, C. Deposit date: 2022-09-28 Release date: 2022-11-30 Last modified: 2023-01-25 Method: ELECTRON MICROSCOPY (3 Å) Cite: Conformational change of alpha-synuclein fibrils in cerebrospinal fluid from different clinical phases of Parkinson's disease. Structure, 31, 2023
8H05	Minor polymorph in alpha-synuclein fibril seeded by cerebrospinal fluid from a postmortal Parkinson's disease patient Descriptor: Alpha-synuclein Authors: Fan, Y, Sun, Y.P, Wang, J, Liu, C. Deposit date: 2022-09-28 Release date: 2022-11-30 Last modified: 2023-01-25 Method: ELECTRON MICROSCOPY (3.4 Å) Cite: Conformational change of alpha-synuclein fibrils in cerebrospinal fluid from different clinical phases of Parkinson's disease. Structure, 31, 2023
8GF7	Cryo-EM structure of serine 87 O-GlcNAc-modified alpha-synuclein fibrils Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, Alpha-synuclein Authors: Balana, J.A, Nguyen, A.B, Saelices, L, Pratt, R.M. Deposit date: 2023-03-07 Release date: 2023-11-08 Last modified: 2024-05-15 Method: ELECTRON MICROSCOPY (4.8 Å) Cite: O-GlcNAc forces an alpha-synuclein amyloid strain with notably diminished seeding and pathology. Nat.Chem.Biol., 20, 2024
8HZC	Formed alpha-synuclein fibrils after incubation with heparin for 1 hour (Hep-remod-2) Descriptor: Alpha-synuclein Authors: Tao, Y.Q, Zhao, Q.Y, Liu, C, Li, D. Deposit date: 2023-01-08 Release date: 2024-01-10 Method: ELECTRON MICROSCOPY (3.2 Å) Cite: Formed alpha-synuclein fibrils after incubation with heparin for 1 hour (Hep-remod-2) To Be Published
8HZS	Formed alpha-synuclein fibrils after incubation with heparin for 3 days (Hep-remod-3) Descriptor: Alpha-synuclein Authors: Tao, Y.Q, Zhao, Q.Y, Liu, C, Li, D. Deposit date: 2023-01-09 Release date: 2024-01-10 Method: ELECTRON MICROSCOPY (3.3 Å) Cite: Formed alpha-synuclein fibrils after incubation with heparin for 3 days (Hep-remod-3) To Be Published
8HZB	Formed alpha-synuclein fibrils after incubation with heparin for 1 hour (Hep-remod-1) Descriptor: Alpha-synuclein Authors: Tao, Y.Q, Zhao, Q.Y, Liu, C, Li, D. Deposit date: 2023-01-08 Release date: 2024-01-10 Method: ELECTRON MICROSCOPY (3.2 Å) Cite: Formed alpha-synuclein fibrils after incubation with heparin for 1 hour (Hep-remod-1) To Be Published
8JEY	Cryo-EM structure of alpha-synuclein pS87 fibril Descriptor: Alpha-synuclein Authors: Xia, W.C, Sun, Y.P, Liu, C. Deposit date: 2023-05-16 Release date: 2024-04-17 Last modified: 2024-05-08 Method: ELECTRON MICROSCOPY (2.6 Å) Cite: Phosphorylation and O-GlcNAcylation at the same alpha-synuclein site generate distinct fibril structures. Nat Commun, 15, 2024

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